Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lothar F. Fecker"'
Autor:
Jürgen Eberle, Lothar F. Fecker
Publikováno v:
Melanoma Development ISBN: 9783319413174
Despite the recent development of new, promising strategies for melanoma, therapy resistance and tumor relapse remained major problems. As therapeutic strategies particularly aim at an induction of apoptosis, deficient proapoptotic signaling appears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e80d0554536df2e3fe1f8d6349ba1a9
https://doi.org/10.1007/978-3-319-41319-8_10
https://doi.org/10.1007/978-3-319-41319-8_10
Autor:
Frank K. Braun, Michael Plötz, Lothar F. Fecker, Nadya Al-Yacoub, Wolfram Sterry, Jürgen Eberle, Markus Möbs
Publikováno v:
Journal of Investigative Dermatology. 132(9):2263-2274
Suberoylanilide hydroxamic acid (SAHA) has been approved for the treatment of cutaneous T-cell lymphoma (CTCL), but its mode of action remained largely elusive. As shown here in four CTCL cell lines, loss of cell viability correlated with significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65fd3c8674b80d1fcf9d151e9452e4e
Publikováno v:
Experimental Dermatology. 21:520-525
Actinic keratosis (AK) is characterized by high prevalence and the risk to proceed to squamous cell carcinoma (SCC). Cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 (PGE (2) ) synthesis has been reported in AK and SCC, and the COX inhibitor diclof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8848f2ee08bacb4189983ec684c53de8
https://doi.org/10.1111/j.1600-0625.2012.01516.x
https://doi.org/10.1111/j.1600-0625.2012.01516.x
Autor:
Frank K. Braun, Lothar F. Fecker, Eggert Stockfleth, Martin Leverkus, Anja Köhler, Constanze Schwarz, Jürgen Eberle, Paul M. Rodust
Publikováno v:
Journal of Investigative Dermatology. 130(8):2098-2109
Actinic keratosis (AK) occurs on sun-exposed skin and may progress to invasive squamous cell carcinoma (SCC). As for its topical treatment, diclofenac/hyaluronic acid (HA) has been recently approved. The NSAID diclofenac is an inhibitor of COX-2; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15419c1ba25a2d3179bffcf04fa595a
Autor:
Stefanie Jost, Amir M. Hossini, Almudena Hurtado Picó, Lothar F. Fecker, Magdalena Schmude, Xiaomin Wang, Jürgen Eberle, Henry Fechner, Constanze Schwarz
Publikováno v:
Experimental Dermatology. 19:e56-e66
The high mortality of melanoma demands the development of new strategies, and gene therapy may be considered provided improvements in efficacy and selectivity. Overexpression of the death ligand CD95L/FasL has been shown in previous studies as highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f73d7fd5cdaba5b1a2b1c3fbaa5a040e
https://doi.org/10.1111/j.1600-0625.2009.00977.x
https://doi.org/10.1111/j.1600-0625.2009.00977.x
Publikováno v:
Experimental Dermatology. 17:1-11
In the last decades melanoma incidence has been increasing worldwide, while mortality remained on a high level. Until now, there is no suitable therapy for metastasized melanoma, which could lead to a significant increase in overall survival. Apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58403c92897272a02a0bfd2779032ff0
https://doi.org/10.1111/j.1600-0625.2007.00655.x
https://doi.org/10.1111/j.1600-0625.2007.00655.x
Publikováno v:
Drug Resistance Updates. 10:218-234
The increased incidence of malignant melanoma in the last decades, its high mortality and pronounced therapy resistance pose an enormous challenge. Important therapeutic targets for melanoma are the induction of apoptosis and suppression of survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3538755cf5658a7425929531a4fe46ee
https://doi.org/10.1016/j.drup.2007.09.001
https://doi.org/10.1016/j.drup.2007.09.001
Autor:
Joachim Röwert-Huber, Claas Ulrich, E Stockfleth, T. Forschner, Lothar F. Fecker, Jürgen Eberle
Publikováno v:
British Journal of Dermatology. 156:18-24
Apoptosis pathways provide efficient safeguard mechanisms against cancer that are mediated via cell-intrinsic responses and immune-mediated extrinsic signals. Intrinsic pro-apoptotic pathways are largely controlled by p53 and Bcl-2 proteins, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceb00397bdeb860d1b48862db09c78a
https://doi.org/10.1111/j.1365-2133.2007.07855.x
https://doi.org/10.1111/j.1365-2133.2007.07855.x
Publikováno v:
Oncogene. 26:3364-3377
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention as a novel anticancer agent. However, its efficiency may be diminished by occurring resistance in cancer cells. The mechanisms of TRAIL resistance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1719ad47b4810b37eeaab42f0bd55f9
https://doi.org/10.1038/sj.onc.1210134
https://doi.org/10.1038/sj.onc.1210134
Autor:
Georgi Tchernev, Bachtier M. Kurbanov, Lothar F. Fecker, Jürgen Eberle, Chalid Assaf, Constanze Schwarz, Uwe Trefzer, Christoph C. Geilen, Peter T. Daniel
Publikováno v:
Journal of Investigative Dermatology. 126:1366-1371
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness. However, more reliable prognostic markers are needed that allow a better stratification of patients, especially with regard to therapeutic options.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab0fcf13485a2497d84f4653774a5a7
https://doi.org/10.1038/sj.jid.5700192
https://doi.org/10.1038/sj.jid.5700192