A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway.

Autor: Karam HM; Drug Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. heba.karam.mohmed@gmail.com., Lotfy DM; Drug Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt., A Ibrahim A; Drug Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.; Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada., Mosallam FM; Drug Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. farag.abomosalam@eaea.org.eg., Abdelrahman SS; Anatomic Pathology Department, Faculty of Veterinary medicine, Cairo University, Cairo, Egypt., Abd-ElRaouf A; Drug Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Sep; Vol. 397 (9), pp. 6919-6927. Date of Electronic Publication: 2024 Apr 09.

Ipomoea carnea mitigates ethanol-induced ulcers in irradiated rats via Nrf2/HO ^-1 pathway: an in vivo and in silico study.

Autor: Ghareeb MA; Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., Mohammed HS; Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11311, Egypt., Aboushousha T; Department of Pathology, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., Lotfy DM; Drug Radiation Research Department, National Center for Radiation Research and Technology, (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., El-Shazly MAM; Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Warrak El-Hadar, Imbaba, P.O. Box 30, Giza, 12411, Egypt., Sobeh M; AgroBioSciences, Mohammed VI Polytechnic University, Lot 660, Hay Moulay Rachid, 43150, Ben-Guerir, Morocco., Taha EFS; Health Radiation Research Department, National Center for Radiation Research and Technology, (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt. emanfayezsaid@gmail.com.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 12; Vol. 14 (1), pp. 3469. Date of Electronic Publication: 2024 Feb 12.

Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors.

Autor: Soliman AM; Drug Chemistry Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Ghorab WM; Drug Chemistry Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Lotfy DM; Pharmacology and Toxicology Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Karam HM; Pharmacology and Toxicology Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt., Ghorab MM; Drug Chemistry Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, 11787, Egypt. mmsghorab@yahoo.com., Ramadan LA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo-Suez Road, Badr City, Cairo, 11829, Egypt.

Publikováno v: Scientific reports [Sci Rep] 2023 Sep 20; Vol. 13 (1), pp. 15546. Date of Electronic Publication: 2023 Sep 20.

Nrf2 and NF-қB interplay in tamoxifen-induced hepatic toxicity: A promising therapeutic approach of sildenafil and low-dose γ radiation.

Autor: Karam HM; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Galal SM; Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Lotfy DM; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

Publikováno v: Environmental toxicology [Environ Toxicol] 2023 May; Vol. 38 (5), pp. 990-996. Date of Electronic Publication: 2023 Jan 30.

Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway.

Autor: Lotfy DM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt., Safar MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Department of Pharmacology and Biochemistry, The British University in Egypt, Cairo, Egypt., Hassan SHM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt., Kenawy SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Publikováno v: Toxicology mechanisms and methods [Toxicol Mech Methods] 2022 Jan; Vol. 32 (1), pp. 18-26. Date of Electronic Publication: 2021 Jul 26.