Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Lotfi Chouchane"'
Autor:
Lilia Romdhane, Sameh Kefi, Nessrine Mezzi, Najla Abassi, Haifa Jmel, Safa Romdhane, Jingxuan Shan, Lotfi Chouchane, Sonia Abdelhak
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Admixture mapping has been useful in identifying genetic variations linked to phenotypes, adaptation and diseases. Copy number variations (CNVs) represents genomic structural variants spanning large regions of chromosomes reaching several me
Externí odkaz:
https://doaj.org/article/74ddedd6d9b74cfca46ce714398b9c4f
Autor:
Halema Al-Farsi, Iman Al-Azwani, Joel A. Malek, Lotfi Chouchane, Arash Rafii, Najeeb M. Halabi
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are essential to tumor d
Externí odkaz:
https://doaj.org/article/cef8992aa6344a3d8dbeb94ea4a73873
Autor:
Nesrine Mabrouk, Cindy Racoeur, Jingxuan Shan, Aurélie Massot, Silvia Ghione, Malorie Privat, Lucile Dondaine, Elise Ballot, Caroline Truntzer, Romain Boidot, François Hermetet, Valentin Derangère, Mélanie Bruchard, Frédérique Végran, Lotfi Chouchane, François Ghiringhelli, Ali Bettaieb, Catherine Paul
Publikováno v:
Cancers, Vol 15, Iss 12, p 3129 (2023)
(1) Background: Immunosuppression is a key barrier to effective anti-cancer therapies, particularly in triple-negative breast cancer (TNBC), an aggressive and difficult to treat form of breast cancer. We investigated here whether the combination of d
Externí odkaz:
https://doaj.org/article/44d86c88e4684cd3b6987faf51ff333b
Autor:
Lilia Romdhane, Nessrine Mezzi, Hamza Dallali, Olfa Messaoud, Jingxuan Shan, Khalid A. Fakhro, Rym Kefi, Lotfi Chouchane, Sonia Abdelhak
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-18 (2021)
Abstract Copy number variation (CNV) is considered as the most frequent type of structural variation in the human genome. Some CNVs can act on human phenotype diversity, encompassing rare Mendelian diseases and genomic disorders. The North African po
Externí odkaz:
https://doaj.org/article/399d7564503448b8a9d14b264646b319
Precision medicine in the era of artificial intelligence: implications in chronic disease management
Autor:
Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud, Lotfi Chouchane
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several molecules which in turn trigger th
Externí odkaz:
https://doaj.org/article/7474f0910e8b4a6cb0f759f4b08eb8a3
Autor:
Silvia Ghione, Cindy Racoeur, Nesrine Mabrouk, Jingxuan Shan, Emma Groetz, Elise Ballot, Caroline Truntzer, Lotfi Chouchane, Frédérique Végran, Catherine Paul, Stéphanie Plenchette, Ali Bettaieb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy has allowed major advances in oncology in the past years, in particular with the development of immune checkpoint inhibitors, but the clinical benefits are still limited, particularly in colorectal cancer (CRC). Our scientific approach
Externí odkaz:
https://doaj.org/article/2341957bf72b4c7e87e49db9cfb8f168
Autor:
Elham Hassen, Devendra Bansal, Randa Ghdira, Anouar Chaieb, Hedi Khairi, Abdelfattah Zakhama, Sami Remadi, Johan Hoebeke, Ali A. Sultan, Lotfi Chouchane
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background In the past decade, cervical cancer has gone from being the second to the fourth most common cancer in women worldwide, but remains the second most common in developing countries. This cancer is most commonly caused by high-risk t
Externí odkaz:
https://doaj.org/article/fda8d7533eec4c71becab3b1ad3d41fb
Autor:
Muna Al Hashmi, Konduru S. Sastry, Lee Silcock, Lotfi Chouchane, Valentina Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco M. Marincola, Sara Tomei
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-9 (2020)
Abstract Background Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. Methods DNA and RNA mutation
Externí odkaz:
https://doaj.org/article/76b0fbde5d5541b99ead96b5816d2060
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothe
Externí odkaz:
https://doaj.org/article/74965d177f86438a8ecda1f4140663ba
Autor:
Maroua Boujemaa, Najah Mighri, Lotfi Chouchane, Mohamed Samir Boubaker, Sonia Abdelhak, Hamouda Boussen, Yosr Hamdi
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265638 (2022)
Significant advances have been made to understand the genetic basis of breast cancer. High, moderate and low penetrance variants have been identified with inter-ethnic variability in mutation frequency and spectrum. Genome wide association studies (G
Externí odkaz:
https://doaj.org/article/c4934347bfe440db95002c222dad17d3