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Antibiotic Glycosyltransferases:  Antibiotic Maturation and Prospects for Reprogramming

Autor: Walsh, C., Meyers, C. L. Freel, Losey, H. C.

Publikováno v: Journal of Medicinal Chemistry; July 2003, Vol. 46 Issue: 16 p3425-3436, 12p

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.

Autor: Walsh CT; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. christopher_walsh@hms.harvard.edu, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM

Publikováno v: Current opinion in chemical biology [Curr Opin Chem Biol] 2001 Oct; Vol. 5 (5), pp. 525-34.

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

Autor: Losey HC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA., Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT

Publikováno v: Biochemistry [Biochemistry] 2001 Apr 17; Vol. 40 (15), pp. 4745-55.

The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates.

Autor: Ehmann DE; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Shaw-Reid CA, Losey HC, Walsh CT

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2000 Mar 14; Vol. 97 (6), pp. 2509-14.