Výsledky vyhledávání - "Losartan/pharmacology"

Can patiromer allow for intensified renin-angiotensin-aldosterone system blockade with losartan and spironolactone leading to decreased albuminuria in patients with chronic kidney disease, albuminuria and hyperkalaemia? An open-label randomised controlled trial: MorphCKD

Autor: Frederik Husum Mårup, Christian Daugaard Peters, Jeppe Hagstrup Christensen, Henrik Birn

Publikováno v: Mårup, F H, Peters, C D, Christensen, J H & Birn, H 2022, ' Can patiromer allow for intensified renin-angiotensin-aldosterone system blockade with losartan and spironolactone leading to decreased albuminuria in patients with chronic kidney disease, albuminuria and hyperkalaemia? An open-label randomised controlled trial: MorphCKD ', BMJ Open, vol. 12, no. 2, e057503 . https://doi.org/10.1136/bmjopen-2021-057503

IntroductionChronic kidney disease (CKD) is associated with significantly increased morbidity and mortality. No specific treatment of the underlying condition is available for the majority of patients, but ACE-inhibitors (ACE-I) and angiotensin II-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3745bc99033954d7cd3d79e4a3a346d3
https://pubmed.ncbi.nlm.nih.gov/35190442

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Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors

Autor: Patrick Vanderheyden, Enrico Gratton, Catherina Caballero-George, Michelle A. Digman, Nadir Planes

The angiotensin II AT1 and the endothelin 1 ETA receptors play a crucial role in the pathogenesis of cardiovascular diseases like hypertension, heart failure, stroke, pulmonary hypertension, and cardiac hypertrophy. Both receptors are members of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfaf7a18d31c79da33fc9286cdc547b4
https://doi.org/10.1016/j.bbagen.2019.03.004

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The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells

Autor: Pires, Paulo W, Ko, Eun-A, Pritchard, Harry A T, Rudokas, Michael, Yamasaki, Evan, Earley, Scott

Publikováno v: Pires, P W, Ko, E-A, Pritchard, H A T, Rudokas, M, Yamasaki, E & Earley, S 2017, ' The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells ', The Journal of physiology, vol. 595, no. 14, pp. 4735-4753 . https://doi.org/10.1113/JP274310

KEY POINTS: The angiotensin II receptor type 1b (AT1 Rb ) is the primary sensor of intraluminal pressure in cerebral arteries. Pressure or membrane-stretch induced stimulation of AT1 Rb activates the TRPM4 channel and results in inward transient cati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::29b71682c21906026aa08b2897ddba4f
https://doi.org/10.1113/JP274310

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Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway

Autor: Guillaume Vial, Domenico Bosco, Jennifer Rieusset, Fabien Van Coppenolle, Anne-Marie Madec, R. Cassel, Sylvie Ducreux, Aurelia Mesnier, Charles Thivolet, Karim Chikh, Marie-Agnès Chauvin, Séverine Dubois

Publikováno v: FASEB Journal, Vol. 27, No 12 (2013) pp. 5122-30

As shown in a large clinical prospective trial, inhibition of the renin-angiotensin system (RAS) can delay the onset of type 2 diabetes in high-risk individuals. We evaluated the beneficial effects of RAS inhibition on β-cell function under glucotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3098c905ed4c7623fc5a13dd2626d9f9
https://archive-ouverte.unige.ch/unige:34324

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Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia

Autor: Daskalopoulou, S. S., Tzovaras, V., Mikhailidis, D. P., Elisaf, M. S.

Beyond allopurinol and the well-established uricosuric drugs, several other agents can decrease serum uric acid (SUA) levels, such as losartan, fenofibrate and some non-steroidal anti-inflammatory drugs (NSAIDs). Some of these drugs increase renal ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::8c637af2fbeb290878e0f9ba8acd936b
http://olympias.lib.uoi.gr/jspui/handle/123456789/22149

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Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes

Autor: Michel Burnier, Jürg Nussberger, Giulio Gabbiani, Hans R. Brunner, Edith Hummler, Qing Wang, Sophie Clément

Publikováno v: Journal of the American Society of Nephrology, Vol. 13, No 6 (2002) pp. 1509-1516

Several studies have demonstrated that mice are polymorphic for the number of renin genes, with some inbred strains harboring one gene (Ren-1(c)) and other strains containing two genes (Ren-1(d) and Ren-2). In this study, the effects of 1% salt and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca7aba384cac8f5d872e3a836a2e9a1
https://archive-ouverte.unige.ch/unige:155772

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