Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lorrie P. Daggett"'
Autor:
Clemens R. Scherzer, G.Bernhard Landwehrmeyer, Julie A. Kerner, David G. Standaert, Zane R. Hollingsworth, Lorrie P. Daggett, Gönül Veliçelebi, John B. Penney, Jr., Anne B. Young
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 1, Pp 35-46 (1997)
We have used a quantitativein situhybridization method with human ribonucleotide probes to examine the regional and cellular distribution ofN-methyl-d-aspartate receptor (NMDAR) subunit mRNAs in the human cerebellum. Purkinje cells showed very dense
Externí odkaz:
https://doaj.org/article/d11cc9b8468c40a4a780e439ed95a9e5
Autor:
Jeffrey McQuiston, Laura S. Lubbers, Lorrie P. Daggett, Theodore M. Kamenecka, Celine Bonnefous, Blake A. Rowe, Hervé Schaffhauser, Sylvia Morales
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:240-251
Glutamate is a major neurotransmitter in the central nervous system, and abnormal glutamate neurotransmission has been implicated in many neurological disorders, including schizophrenia, Alzheimer's disease, Parkinson's disease, addiction, anxiety, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e3441ec046403faa6d68a072d2e96
https://doi.org/10.1124/jpet.108.138271
https://doi.org/10.1124/jpet.108.138271
Autor:
Sandra M. Lechner, Guibao Gu, Linda J. Bristow, Daniel S. Lorrain, Hongbing Wei, Rebecca L. Cole, Lorrie P. Daggett, Xin Zhang, Hervé Schaffhauser
Publikováno v:
Brain Research. 1197:47-62
The receptor localization of metabotropic glutamate receptors (mGlu) 2 and 3 was examined by using in situ hybridization and a well-characterized mGlu2-selective antibody in the rat forebrain. mGlu2 was highly and discretely expressed in cell bodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43079210d858604ef404f6bb3c304e51
https://doi.org/10.1016/j.brainres.2007.12.057
https://doi.org/10.1016/j.brainres.2007.12.057
Autor:
Joyce K. James, Hutchinson John H, Michael F. Gardner, Blake A. Rowe, Hervé Schaffhauser, Lorrie P. Daggett, Rowena V. Cube, Anthony B. Pinkerton, Jean-Michel Vernier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2389-2393
We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency, level of potentiation and brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17be6a326e0e9aef78ba2c1f2659398e
https://doi.org/10.1016/j.bmcl.2005.02.078
https://doi.org/10.1016/j.bmcl.2005.02.078
Autor:
Dana E. Rodriguez, Jean-Michel Vernier, Hutchinson John H, Hervé Schaffhauser, Anthony B. Pinkerton, Lorrie P. Daggett, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Una Campbell, Rowena V. Cube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1565-1571
We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e1edf523edbd2b8328be76da134078
https://doi.org/10.1016/j.bmcl.2005.01.077
https://doi.org/10.1016/j.bmcl.2005.01.077
Autor:
Dana E. Rodriguez, Christopher Baccei, Daniel S. Lorrain, Lorrie P. Daggett, Hervé Schaffhauser, Linda J. Bristow, Blake A. Rowe, Jean-Michel Vernier, Anthony B. Pinkerton, Una Campbell
Publikováno v:
Journal of Medicinal Chemistry. 47:4595-4599
Herein we disclose the discovery of a new class of positive allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2), phenyl-tetrazolyl acetophenones, e.g. 1-(2-hydroxy-3-propyl-4-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl) ethanon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b72043fb5440591709ebe94af776b29
https://doi.org/10.1021/jm040088h
https://doi.org/10.1021/jm040088h
Autor:
J. B. Penney, Gonul Velicelebi, Christoph M. Kosinski, T J Counihan, Clemens R. Scherzer, David G. Standaert, Lorrie P. Daggett, G B Landwehrmeyer, Anne B. Young, J A Kerner
Publikováno v:
The Journal of Comparative Neurology. 390:63-74
N-methyl-D-aspartate receptors (NRs) play an important role in basal ganglia function. By using in situ hybridization with ribonucleotide probes, we investigated the regional and cellular distribution of NR subunit mRNA expression in the human basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86330d0e83f519225f17dd006ea5d7f
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<63::aid-cne6>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<63::aid-cne6>3.0.co
Autor:
Clemens R. Scherzer, T J Counihan, G B Landwehrmeyer, Gonul Velicelebi, J. B. Penney, Christoph M. Kosinski, David G. Standaert, Lorrie P. Daggett, Anne B. Young
Publikováno v:
The Journal of Comparative Neurology. 390:91-101
Evidence is accumulating that glutamate-mediated excitotoxicity plays an important role in neuronal degeneration in Parkinson's disease (PD). In addition, alterations in excitatory amino acid neurotransmission in the basal ganglia contribute to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae3867fd793773c68b92d037196eadf
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co
Expression of N-Methyl-D-Aspartate receptor subunit mRNAs in the human brain: Hippocampus and cortex
Autor:
G B Landwehrmeyer, J. B. Penney, T J Counihan, Anne B. Young, David G. Standaert, Lorrie P. Daggett, Gonul Velicelebi, Clemens R. Scherzer, Christoph M. Kosinski, J A Kerner
Publikováno v:
The Journal of Comparative Neurology. 390:75-90
N-methyl-D-aspartate receptor (NR) activation in the hippocampus and neocortex plays a central role in memory and cognitive function. We analyzed the cellular expression of the five NR subunit (NR1 and NR2A-D) mRNAs in these regions with in situ hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cabf42c8271f14274ac2b52d050201
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<75::aid-cne7>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<75::aid-cne7>3.0.co
Autor:
Lorrie P. Daggett, Peter J. Flor, J A Kerner, Rainer Kuhn, Anne B. Young, Aida I. Sacaan, David G. Standaert, F.-F. Lin, Gonul Velicelebi, C. Jachec, Mark A. Varney, Sara P. Rao
Publikováno v:
Neuropharmacology. 36:917-931
We isolated and characterized a cDNA encoding the human metabotropic glutamate receptor subtype 1b (hmGluR1b). In situ hybridization studies in human brain regions revealed a higher distribution of mGluR1 mRNA in the dentate gyrus of the hippocampus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afcfb231ef05175c7d3420cc0542c60
https://doi.org/10.1016/s0028-3908(97)00078-6
https://doi.org/10.1016/s0028-3908(97)00078-6