Výsledky vyhledávání - "Lorri D. Martin"

FGFR3preferentially colocalizes withIGHin the interphase nucleus of multiple myeloma patient B-cells whenFGFR3is located outside of CT4

Autor: Sabine Mai, Lorri D. Martin, Andrew Belch, Linda M. Pilarski, Jana Harizanova

Publikováno v: Genes, Chromosomes and Cancer. 55:962-974

Many B-cell malignancies are characterized by chromosomal translocations involving IGH and a proto-oncogene. For translocations to occur, spatial proximity of translocation-prone genes is necessary. Currently, it is not known how such genes are broug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d22397e7dec498fb38c80358d3866b6
https://doi.org/10.1002/gcc.22394

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FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B-cells when FGFR3 is located outside of CT4

Autor: Lorri D, Martin, Jana, Harizanova, Sabine, Mai, Andrew R, Belch, Linda M, Pilarski

Publikováno v: Genes, chromosomescancer. 55(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc757339ffd09456612b14fb42d8e626
https://pubmed.ncbi.nlm.nih.gov/27509849

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Differential positioning and close spatial proximity of translocation-prone genes in nonmalignant B-cells from multiple myeloma patients

Autor: Andrew Belch, George Zhu, Lorri D. Martin, Sabine Mai, Christiaan H. Righolt, Linda M. Pilarski, Jana Harizanova

Publikováno v: Genes, Chromosomes and Cancer. 51:727-742

Accumulating evidence suggests that spatial proximity of potential chromosomal translocation partners influences translocation probability. It is not known, however, whether genome organization differs in nonmalignant cells from patients as compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c5ca2c39fb09a8f7740b6b78dca35f
https://doi.org/10.1002/gcc.21959

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A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

Autor: Tony Reiman, Julia Kirshner, Andrew Belch, Kyle J. Thulien, Linda M. Pilarski, Lorri D. Martin, Carina Debes Marun

Publikováno v: Blood. 112:2935-2945

Although the in vitro expansion of the multiple myeloma (MM) clone has been unsuccessful, in a novel three-dimensional (3-D) culture model of reconstructed bone marrow (BM, n = 48) and mobilized blood autografts (n = 14) presented here, the entire MM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaba12301a9303a939c11ae4ce424fd9
https://doi.org/10.1182/blood-2008-02-142430

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Differential nuclear organization of translocation-prone genes in nonmalignant B cells from patients with t(14;16) as compared with t(4;14) or t(11;14) myeloma

Autor: Andrew Belch, Christiaan H. Righolt, Linda M. Pilarski, Lorri D. Martin, Jana Harizanova, George Zhu, Sabine Mai

Publikováno v: Genes, chromosomescancer. 52(6)

Gene organization in nonmalignant B cells from t(4;14) and t(11;14) multiple myeloma (MM) patients differs from that of healthy donors. Among recurrent IGH translocations in MM, the frequency of t(4;14) (IGH and FGFR3) or t(11;14) (IGH and CCND1) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e83e50dc7287f71bfb657eb3fdc33c9
https://pubmed.ncbi.nlm.nih.gov/23460268

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Promiscuity of translocation partners in multiple myeloma

Autor: Linda M. Pilarski, Andrew R. Belch, Lorri D. Martin

Publikováno v: Journal of Cellular Biochemistry.

Multiple myeloma (MM) is characterized by karyotypic instability, including chromosomal translocations involving the IGH locus. MM cells display a promiscuity of translocation partners, only some of which are recurrent. We propose that several factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba484d91eb301de60f706766063af84
https://doi.org/10.1002/jcb.22499

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Cancer-Specific Nuclear Positioning of Translocation Prone Gene Loci In Non-Malignant B-Cells From Patients with Multiple Myeloma

Autor: Andrew R. Belch, Jana Harizanova, George Zhu, Linda M. Pilarski, Sabine Mai, Lorri D. Martin

Publikováno v: Blood. 116:783-783

Abstract 783 Malignant plasma cells from patients with multiple myeloma (MM) display recurrent chromosome translocations involving the immunoglobulin heavy chain locus (IGH) and CCND1 [t(11;14)] or FGFR [t(4;14)]. It is poorly understood why recombin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a85c8583edd05c0ccce61a73d9910229
https://doi.org/10.1182/blood.v116.21.783.783

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A Unique Pre-Clinical Model Providing Access to a Drug Resistant Population within the Multiple Myeloma Stem Cell Niche in a Novel 3-D Culture System for Bone Marrow

Autor: Julia Kirshner, Tony Reiman, Andrew R. Belch, Carina Debes Marun, Lorri D. Martin, Linda M. Pilarski, Kyle J. Thulien

Publikováno v: Blood. 110:547-547

Bone marrow (BM), a site of hematopoiesis, is a multicellular tissue with a complex architecture. Multiple myeloma (MM) is an incurable plasma cell malignancy where even patients in remission succumb to an inevitable relapse. While considerable progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66ab86fbdfd27acefea59134cee5be35
https://doi.org/10.1182/blood.v110.11.547.547

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