Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Lorraine V Kalia"'
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 4, Pp 684-685 (2021)
Externí odkaz:
https://doaj.org/article/ff9f33c9d6824a39be9f6f2c442e5458
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Accumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson’s disease (PD). High frequency electrical stimulation (HFS) mimicking clinical parameters used for deep brain stimulation (DBS)
Externí odkaz:
https://doaj.org/article/ee09962a47ad4a929326c95bfe763b4d
Autor:
Nathan C Rowland, Suneil K Kalia, Lorraine V Kalia, Paul S Larson, Daniel A Lim, Krystof S Bankiewicz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Parkinson's disease (PD) is a complex neurodegenerative disorder that is currently managed using a broad array of symptom-based strategies. However, targeting its molecular origins represents the potential to discover disease-modifying therapies. Dee
Externí odkaz:
https://doaj.org/article/5c1d157fd65345ccbe979325f4cf010a
Autor:
Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia
Publikováno v:
Brain Stimulation, Vol 17, Iss 2, Pp 166-175 (2024)
Background: Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD). Despite its well-established symptomatic benefits, our understanding of the mechanisms
Externí odkaz:
https://doaj.org/article/86e2f9f0b08a4b4987f2500b2e669775
Autor:
Rebecca Earnshaw, Yu Tong Zhang, Gregory Heymann, Kazuko Fujisawa, Sarah Hui, Minesh Kapadia, Lorraine V. Kalia, Suneil K. Kalia
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106625- (2024)
C-terminus of HSP70 interacting protein (CHIP) is an E3 ubiquitin ligase and HSP70 cochaperone. Mutations in the CHIP encoding gene are the cause of two neurodegenerative conditions: spinocerebellar ataxia autosomal dominant type 48 (SCA48) and autos
Externí odkaz:
https://doaj.org/article/982a52532ce347349e5843e7fae51f8c
Autor:
Lorraine V Kalia, Suneil K Kalia, Hien Chau, Andres M Lozano, Bradley T Hyman, Pamela J McLean
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14695 (2011)
Parkinson's disease (PD) is a common neurodegenerative condition in which abnormalities in protein homeostasis, or proteostasis, may lead to accumulation of the protein α-synuclein (α-syn). Mutations within or multiplications of the gene encoding
Externí odkaz:
https://doaj.org/article/555262e0a04c497faca4870861eead7e
Autor:
David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e41 (2009)
The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, U
Externí odkaz:
https://doaj.org/article/3b93d0508888458dabaff426a1a4130a
Autor:
Ying Meng, Lorraine V. Kalia, Suneil K. Kalia, Clement Hamani, Yuexi Huang, Kullervo Hynynen, Nir Lipsman, Benjamin Davidson
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 719 (2024)
This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to transiently permeabilize the blood-brain barrier (BBB) for drug delivery in neurological disorde
Externí odkaz:
https://doaj.org/article/8912977789b44ea4a1207fa3ce0029ee
Autor:
Satra Nim, Darren M. O’Hara, Carles Corbi-Verge, Albert Perez-Riba, Kazuko Fujisawa, Minesh Kapadia, Hien Chau, Federica Albanese, Grishma Pawar, Mitchell L. De Snoo, Sophie G. Ngana, Jisun Kim, Omar M. A. El-Agnaf, Enrico Rennella, Lewis E. Kay, Suneil K. Kalia, Lorraine V. Kalia, Philip M. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction
Externí odkaz:
https://doaj.org/article/5d9353322078445d81d882610543e049
Autor:
Yuexi Huang, Ying Meng, Christopher B. Pople, Allison Bethune, Ryan M. Jones, Agessandro Abrahao, Clement Hamani, Suneil K. Kalia, Lorraine V. Kalia, Nir Lipsman, Kullervo Hynynen
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2607 (2022)
Magnetic resonance-guided focused ultrasound (MRgFUS), in conjunction with circulating microbubbles, is an emerging technology that can transiently enhance the permeability of the blood-brain barrier (BBB) locally and non-invasively to facilitate tar
Externí odkaz:
https://doaj.org/article/c2c534cc2ecb4ce7ba8ddd5945c58e5e