Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

Autor: Neil Bate, Catrin Pritchard, Daniela Mazzeo, Lorraine Spence, Emmanuel Debrand, Francesco J. Conti, David R. Critchley, Susan J. Monkley

Publikováno v: Biochemical and Biophysical Research Communications

Highlights ► Mice lacking talin2 are viable and fertile with only a mildly dystrophic phenotype. ► Talin2 null fibroblasts show no major defects in proliferation, adhesion or migration. ► Maintaining a colony of talin2 null mice is difficult in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2c233303e2a35bed26bb85a038ec1e
https://doi.org/10.1016/j.bbrc.2012.08.061

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

Autor: Susan J. Monkley, Catrin Pritchard, Lorraine Spence, Yasmine El Jai, Neil Bate, Uta Praekelt, David R. Critchley, Emmanuel Debrand

Publikováno v: FEBS Journal. 276:1610-1628

Talins are large adaptor proteins that link the integrin family of adhesion molecules to F-actin. In vertebrates, there are two talin genes. Talin 1 is essential for integrin-mediated cell adhesion; the role of talin 2 is unclear. Here we report a de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d2adb45f728cac37afc67316bf333a2
https://doi.org/10.1111/j.1742-4658.2009.06893.x

A physical map of the mouse genome

Autor: Asif T. Chinwalla, Daniel A. Russell, Richard D. Hutton, Rebecca McGrane, Pawan Pandoh, Catharine Gray, Margaret Krol, Kazutoyo Osoegawa, Mandeep Sekhon, Ewan Birney, Marco A. Marra, Michael Heaney, Reta Kutsche, R Evans, Pieter J. de Jong, Soo Sen Lee, Tony Cox, Elizabeth Gebregeorgis, Carol Scott, Jacqueline E. Schein, Duane E Smailus, David R. Bentley, Parvaneh Saeedi, Glen Threadgold, Ian R Mullenger, Suganthi Chittaranjan, Chris Fjell, Robert H. Waterston, Jim Stalker, Letticia Hsiao, Jason Maas, Martin Krzywinski, Jason Carter, John Douglas Mcpherson, Kelly Mead, Simon G. Gregory, Ian Bosdet, Bola Ayodeji, Anna-Liisa Prabhu, Joel A. Malek, George S. Yang, Dan Layman, Tony Gaige, Keita Geer, Jane Rogers, Tamara Feldblyum, Miranda Tsai, Larry Overton, Sara Jaeger, LaDeana W. Hillier, Kristine M. Wylie, Colin Kremitzki, Sheryl Taylor, Carrie Mathewson, Jyoti Shetty, Wesley Terpstra, James Smith, Getahun Tsegaye, Christopher A Fox, Steve Messervier, Natasja Wye, Candice McLeavy, Jill Vardy, William C. Nierman, Lorraine Spence, Alla Shvartsbeyn, Sofiya Shatsman, Readman Chiu, Claire M. Fraser, Michael Smith, John W. Wallis, Michael C. Holmes, Tim Hubbard, Ran Guin, Shaying Zhao, Jeffrey L Stott, Noreen Girn, Kimbly J Phillips, Rebecca S. Walker, Paul W. Burridge, Joseph J. Catanese, Steven J.M. Jones, Steven R. Ness, Dan Fuhrmann, Susanna Chan, Jennifer Asano

Publikováno v: Nature. 418(6899)

A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromosomal DNA. We have constructed a physical map of the mouse genome that contains 296 contigs of overlapping bacterial clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508dd38733be28e60306eb0bc6ed6d17
https://pubmed.ncbi.nlm.nih.gov/12181558