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Autor:
A Gene Trimble, Henry T Davis, Christopher Cox, Lorraine Sheck, Ronald Hansen, William M Wardell
Publikováno v:
Clinical pharmacology and therapeutics. 36(5)
Drug development in the United States has been characterized by: (1) high attrition and correspondingly low success rates of drug candidates passing through the development sys(2) a steady decline in new chemical entities (NCEs) entering clinical r e