Výsledky vyhledávání - "Lorraine Schmidt"

Akademický článek

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

Autor: Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach,

Externí odkaz: https://doaj.org/article/d581931c5d434a78a70223703dfa1143

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Akademický článek

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Autor: Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and su

Externí odkaz: https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e

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Temperature regulates NF-κB dynamics and function through timing of A20 transcription

Autor: Antony Adamson, William Rowe, Simon West, Claire V. Harper, Michael R. H. White, Connie Lam, David A. Rand, Louise Ashall, Lorraine Schmidt, Polly Downton, Manuel Garcia-Albornoz, Dan J. Woodcock, David G. Spiller

Publikováno v: Harper, C V, Woodcock, D J, Lam, C, Garcia-Albornoz, M, Adamson, A, Ashall, L, Rowe, W, Downton, P, Schmidt, L, West, S, Spiller, D G, Rand, D A & White, M R H 2018, ' Temperature regulates NF-κB dynamics and function through timing of A20 transcription ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. E5243-E5249 . https://doi.org/10.1073/pnas.1803609115
Proceedings of the National Academy of Sciences of the United States of America

Significance Inflammation is often accompanied by temperature change, but little is known about the role of temperature in the inflammatory response. We show that physiologically relevant temperature changes significantly perturb NF-κB dynamics foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d32f0dc16e310babd93e5c64efb9af
https://doi.org/10.1073/pnas.1803609115

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Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Autor: Pawel Paszek, Polly Downton, David A. Rand, Dean A. Jackson, Claire V. Harper, Michael R. H. White, Lorraine Schmidt, William Rowe, Antony Adamson, Apolinar Maya-Mendoza, James Bagnall, David G. Spiller, Connie Lam, Christopher Boddington

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Adamson, A, Boddington, C, Downton, P, Rowe, W, Bagnall, J, Lam, C, Maya-Mendoza, A, Schmidt, L, Harper, C V, Spiller, D, Rand, D A, Jackson, D, White, M R H & Paszek, P 2016, ' Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states ', Nature Communications, vol. 7, 12057 . https://doi.org/10.1038/ncomms12057
Nature Communications

Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (
In b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c03441fa90fdd82e87df576c5fa7d2
https://doi.org/10.1038/ncomms12057

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Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer

Autor: Christopher Boddington, Michael R. H. White, Nicholas Jones, William Rowe, Pawel Paszek, Lorraine Schmidt, James Boyd, Ruth Brignall, David G. Spiller, James Bagnall

Publikováno v: Integrative biology : quantitative biosciences from nano to macro. 7(6)

Live-cell imaging of fluorescent fusion proteins has transformed our understanding of mammalian cell signalling and function. However, some cellular systems such as immune cells are unsuitable or refractory to many existing transgene delivery methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b794ddcb1ecce9f45e8eddc49cac3a64
https://pubmed.ncbi.nlm.nih.gov/25990200

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Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism

Autor: Emmanuel, Pinteaux, Wataru, Inoue, Lorraine, Schmidt, Francisco, Molina-Holgado, Nancy J, Rothwell, Giamal N, Luheshi

Publikováno v: Journal of neurochemistry. 102(3)

Leptin regulates energy balance by suppressing appetite and increasing energy expenditure through actions in the hypothalamus. Recently we demonstrated that the effects of leptin are, at least in part, mediated by the release of interleukin (IL)-1bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5243c72a2b2fc51ce620610608e5dc42
https://pubmed.ncbi.nlm.nih.gov/17419800

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