Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Lorraine Pillus"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The emerging class of multi-functional proteins known as moonlighters challenges the “one protein, one function” mentality by demonstrating crosstalk between biological pathways that were previously thought to be functionally discrete. H
Externí odkaz:
https://doaj.org/article/8bf9d23e451d4d6fa57054066b4a820e
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 4 (2023)
AbstractCovalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair. Many histone modifications have been character
Externí odkaz:
https://doaj.org/article/f13a66018b084fed80f0f0ffab3c650d
Autor:
Julie Paxman, Zhen Zhou, Richard O'Laughlin, Yuting Liu, Yang Li, Wanying Tian, Hetian Su, Yanfei Jiang, Shayna E Holness, Elizabeth Stasiowski, Lev S Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Publikováno v:
eLife, Vol 11 (2022)
Chromatin instability and protein homeostasis (proteostasis) stress are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed that, d
Externí odkaz:
https://doaj.org/article/8b123c5e430f4c03951e121b50a9be75
Publikováno v:
Translational Medicine of Aging, Vol 4, Iss , Pp 151-160 (2020)
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Theref
Externí odkaz:
https://doaj.org/article/15f33c91c5894ffb88187e73b51b188c
Autor:
Esther Magdalena Marquez-Lona, Ana Lilia Torres-Machorro, Frankie R Gonzales, Lorraine Pillus, Gentry N Patrick
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179893 (2017)
The ubiquitin proteasome system (UPS) is a highly conserved and tightly regulated biochemical pathway that degrades the majority of proteins in eukaryotic cells. Importantly, the UPS is responsible for counteracting altered protein homeostasis induce
Externí odkaz:
https://doaj.org/article/5091015b3aa94407bdbb32294aaba230
Autor:
Mark A. McCormick, Amanda G. Mason, Stephan J. Guyenet, Weiwei Dang, Renee M. Garza, Marc K. Ting, Rick M. Moller, Shelley L. Berger, Matt Kaeberlein, Lorraine Pillus, Albert R. La Spada, Brian K. Kennedy
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 477-486 (2014)
We have analyzed the yeast replicative lifespan of a large number of open reading frame (ORF) deletions. Here, we report that strains lacking genes SGF73, SGF11, and UBP8 encoding SAGA/SLIK complex histone deubiquitinase module (DUBm) components are
Externí odkaz:
https://doaj.org/article/d020c0d5f8e2485cae360dc3ca05a867
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 128-137 (2013)
Classic “position-effect” experiments repositioned genes near telomeres to demonstrate that the epigenetic landscape can dramatically alter gene expression. Here, we show that systematic gene knockout collections provide an exceptional resource f
Externí odkaz:
https://doaj.org/article/b3fddaff64d44eb5bf78b41925729e08
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002994 (2012)
Chromatin-modifying enzymes and ATP-dependent remodeling complexes have been intensely studied individually, yet how these activities are coordinated to ensure essential cell functions such as transcription, replication, and repair of damage is not w
Externí odkaz:
https://doaj.org/article/3ed27cadd4454a3d888b8739ad559062
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4746 (2009)
Distal interactions between discrete elements of an enzyme are critical for communication and ultimately for regulation. However, identifying the components of such interactions has remained elusive due to the delicate nature of these contacts. Prote
Externí odkaz:
https://doaj.org/article/b5d8639866f544e0a762c1d17e3b6d6b
Autor:
Zhen Zhou, Yuting Liu, Yushen Feng, Stephen Klepin, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Publikováno v:
Science. 380:376-381
Synthetic biology enables the design of gene networks to confer specific biological functions, yet it remains a challenge to rationally engineer a biological trait as complex as longevity. A naturally occurring toggle switch underlies fate decisions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9edd23ea5a6c76bfdc9b5a0b8388320f
https://doi.org/10.1126/science.add7631
https://doi.org/10.1126/science.add7631