Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lorraine Pelosof"'
Autor:
David J. Pinato, Xiaoxue Li, Pallavi Mishra-Kalyani, Antonio D’Alessio, Claudia A.M. Fulgenzi, Bernhard Scheiner, Matthias Pinter, Guo Wei, Julie Schneider, Donna R. Rivera, Richard Pazdur, Marc R. Theoret, Sandra Casak, Steven Lemery, Lola Fashoyin-Aje, Alessio Cortellini, Lorraine Pelosof
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100747- (2023)
Background & Aims: Immune checkpoint inhibitors (ICIs) alone or in combination with other ICIs or vascular endothelial growth factor pathway inhibitors are therapeutic options in unresectable/metastatic hepatocellular carcinoma (HCC). Whether antibio
Externí odkaz:
https://doaj.org/article/6927577eae4849a9b007d6bf4469b648
Autor:
Lai Xu, Helen Luo, Rong Wang, Wells W. Wu, Je-Nie Phue, Rong-Fong Shen, Hartmut Juhl, Leihong Wu, Wei-lun Alterovitz, Vahan Simonyan, Lorraine Pelosof, Amy S. Rosenberg
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Reference genes are often interchangeably called housekeeping genes due to 1) the essential cellular functions their proteins provide and 2) their constitutive expression across a range of normal and pathophysiological conditions.
Externí odkaz:
https://doaj.org/article/4139dfba11ea48ae9b6493a2f0e9f38d
Autor:
Lai Xu, Lorraine Pelosof, Rong Wang, Hugh I. McFarland, Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Rong-Fong Shen, Hartmut Juhl, Lei-Hong Wu, Wei-Lun Alterovitz, Emanuel Petricon, Amy S. Rosenberg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
To evaluate the expression of immune checkpoint genes, their concordance with expression of IFNγ, and to identify potential novel ICP related genes (ICPRG) in colorectal cancer (CRC), the biological connectivity of six well documented (“classical
Externí odkaz:
https://doaj.org/article/3f067d4684b54e6e887a0e30459c6914
Autor:
Lorraine Pelosof, Sashidhar Yerram, Todd Armstrong, Nina Chu, Ludmila Danilova, Breann Yanagisawa, Manuel Hidalgo, Nilofer Azad, James G. Herman
Publikováno v:
Epigenetics, Vol 12, Iss 7, Pp 540-550 (2017)
Epigenetic control of gene expression is a major determinant of tumor phenotype and has been found to influence sensitivity to individual chemotherapeutic agents. Glutathione peroxidase 3 (GPX3, plasma glutathione peroxidase) is a key component of ce
Externí odkaz:
https://doaj.org/article/ef0106233e1b4f0ead57cee02a0bc36a
Autor:
Kirsten B. Goldberg, Paul G. Kluetz, Ann T. Farrell, Julia A. Beaver, Patricia Keegan, Gideon M. Blumenthal, Janaki Veeraraghavan, Laleh Amiri-Kordestani, Yutao Gong, Lorraine Pelosof, Harpreet Singh, Steven Lemery, Elaine Chang, Guo Wei, Nicole J. Gormley, Richard Pazdur, Marc R. Theoret, Lola Fashoyin-Aje
Publikováno v:
The Oncologist
Background To review and summarize all U.S. Food and Drug Administration (FDA) approvals of programmed death (PD)‐1 and PD‐ligand 1 blocking antibodies (collectively referred to as PD‐[L]1 inhibitors) over a 6‐year period and corresponding co
Autor:
Sirisha Mushti, Lola Fashoyin-Aje, Steven Lemery, Marc R. Theoret, Kirsten B. Goldberg, Joyce Cheng, Lorraine Pelosof, May Tun Saung, Xiling Jiang, Richard Pazdur, Martha Donoghue, Jiang Liu, Sandra Casak, Maryam Khazraee, Hong Zhao
Publikováno v:
Oncologist
On June 10, 2020, the U.S. Food and Drug Administration (FDA) approved nivolumab (OPDIVO; Bristol Myers Squibb, New York, NY) for the treatment of patients with unresectable advanced, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC)
Autor:
Kemp H. Kernstine, Ralph J. DeBerardinis, Chyndhri Padmanabhan, Jessica Saltarski, Quyen N. Do, Ivan Pedrosa, Lorraine Pelosof, Chul Ahn, Rachael Skelton, David E. Gerber, Raja Reddy Kallem, Sahba Kasiri, Scott I. Reznik, Yin Xi, Farjana J. Fattah, Rolf A. Brekken, Richard D. Leff, Vaidehi Chembukar, William C. Putnam, James Kim, Robert E. Lenkinski, Brandon Faubert, Qing Yuan, Indhumathy Subramaniyan
Publikováno v:
Clin Cancer Res
Purpose: Itraconazole has been repurposed as an anticancer therapeutic agent for multiple malignancies. In preclinical models, itraconazole has antiangiogenic properties and inhibits Hedgehog pathway activity. We performed a window-of-opportunity tri
Publikováno v:
The AAPS Journal. 23
Immune checkpoint inhibitors (ICIs) represent a promising therapy for many types of cancer. However, only a portion of patients respond to this therapy and some patients develop clinically significant immune-mediated liver injury caused by immune che
Autor:
Kirsten B. Goldberg, Thomas U. Marron, Yutao Gong, Chieh J. Lee, Celina Ang, Pallavi S. Mishra-Kalyani, Tiziana Pressiani, Thoetchai Peeraphatdit, Lola Fashoyin-Aje, Anushi Bulumulle, Elad Sharon, Mahvish Muzaffar, Alessio Cortellini, Pei Chang Lee, Ahmed Kaseb, David J. Pinato, Steven Lemery, Uqba Khan, Anwaar Saeed, Sonal Paul, Yinghong Wang, Yehia I. Abugabal, Bo Yu, Tomi Jun, Sirish Dharmapuri, Nicola Personeni, Lorenza Rimassa, Antonio D'Alessio, Guo Wei, Marc R. Theoret, Musharraf Navaid, Anuhya Gampa, Richard Pazdur, Hannah Hildebrand, Abdul Rafeh Naqash, Neil Nimkar, Yi Hsiang Huang, David Szafron, Julie A. Schneider, Lorraine Pelosof, Dominik Bettinger, Anjana Pillai
Publikováno v:
European journal of cancer (Oxford, England : 1990). 157
Purpose The development of treatment-related adverse events (trAE) correlates favorably with clinical outcomes in multiple studies of patients receiving immune checkpoint inhibitors (ICI); however, this relationship is undefined in patients with hepa
Publikováno v:
The AAPS journal. 23(5)
Immune checkpoint inhibitors (ICIs) represent a promising therapy for many types of cancer. However, only a portion of patients respond to this therapy and some patients develop clinically significant immune-mediated liver injury caused by immune che