Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lorraine Morlock"'
Autor:
Li-shu Zhang, Xunlei Kang, Jianming Lu, Yuannyu Zhang, Xiaofeng Wu, Guojin Wu, Junke Zheng, Rubina Tuladhar, Heping Shi, Qiaoling Wang, Lorraine Morlock, Huiyu Yao, Lily Jun-shen Huang, Pascal Maire, James Kim, Noelle Williams, Jian Xu, Chuo Chen, Cheng Cheng Zhang, Lawrence Lum
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 145-158 (2019)
Background: Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenes
Externí odkaz:
https://doaj.org/article/73d06b7f64ea44e7a85caf179ec3fdad
Autor:
Lorraine Morlock, Jef K. De Brabander, Jerry W. Shay, Lu Zhang, Noelle S. Williams, Wentian Wang
Publikováno v:
J Med Chem
Despite advances in targeted anticancer therapies, there are still no small-molecule-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0065ea2b6e0e099255b5163ddb235121
https://doi.org/10.1021/acs.jmedchem.9b00532
https://doi.org/10.1021/acs.jmedchem.9b00532
Autor:
Huiyu Yao, Junke Zheng, Li-shu Zhang, Lawrence G. Lum, Cheng Cheng Zhang, Lily Jun Shen Huang, Jianming Lu, Heping Shi, Noelle S. Williams, Pascal Maire, James Kim, Rubina Tuladhar, Lorraine Morlock, Chuo Chen, Xiaofeng Wu, Jian Xu, Xunlei Kang, Qiaoling Wang, Yuannyu Zhang, Guojin Wu
Publikováno v:
EBioMedicine
Background Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06527c59cdc183ec9e77f7aa29ac8ad
https://doi.org/10.1016/j.ebiom.2018.11.039
https://doi.org/10.1016/j.ebiom.2018.11.039
Autor:
Noelle S. Williams, Lorraine Morlock, Xiangbing Qi, Wen Jun Gui, Cheng Yang Wu, David T. Chuang, R. Max Wynn, Mingliang Lou, Jacinta L. Chuang, Shih Chia Tso
Publikováno v:
Journal of Medicinal Chemistry. 60:1142-1150
Pyruvate dehydrogenase kinases 1–4 (PDK1-4) negatively control activity of the pyruvate dehydrogenase complex (PDC) and are up-regulated in obesity, diabetes, heart failure and cancer. We reported earlier two novel pan-PDK inhibitors PS8 [4-((5-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b3d074c1d16c8a0568cde22c4549a8
https://doi.org/10.1021/acs.jmedchem.6b01540
https://doi.org/10.1021/acs.jmedchem.6b01540
Autor:
Lawrence G. Lum, Chengwei Zhang, Xiaolei Wang, Nageswari Yarravarapu, Lin You, Lishu Zhang, Noelle S. Williams, Chuo Chen, Lorraine Morlock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5891-5895
The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. We have previously discovered four molecular scaffolds harboring Porcn-inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0834317fcad6bb8306b56034afcdaf
https://doi.org/10.1016/j.bmcl.2016.11.012
https://doi.org/10.1016/j.bmcl.2016.11.012
Autor:
Huiyu Yao, Lily Jun Shen Huang, James Kim, Chuo Chen, Rubina Tuladhar, Junke Zheng, Cheng Cheng Zhang, Xiaofeng Wu, Lorraine Morlock, Heping Shi, Qiaoling Wang, Jian Xu, Xunlei Kang, Yuannyu Zhang, Lawrence G. Lum, Guojin Wu, Noelle S. Williams, Jianming Lu, Pascal Maire, Li-shu Zhang
Publikováno v:
SSRN Electronic Journal.
The oncofusion protein MLL-AF9 promotes acute myeloid leukemia (AML) by altering histone methylation and DNA accessibility to transcriptional machinery. Using antagonists of WNT signaling and genetic ablation of the WNT chaperone Wntless (WLS), we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c807fbd99d5ae189b3d0428667a617
https://doi.org/10.2139/ssrn.3266970
https://doi.org/10.2139/ssrn.3266970
Autor:
Tessa Gordon, Noelle S. Williams, Stephen W.P. Kemp, Matthew D. Wood, Joseph M. Ready, Thomas J. Mangano, Michael P. Willand, K. N. Stanoulis, Andrew A. Pieper, Simon Beggs, Mark Szynkaruk, Jacinth Naidoo, Lorraine Morlock, Michael W. Salter, Edward H. Liu, G. H. Borschel
Publikováno v:
Neuroscience. 284:202-216
Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0bb911c03f5958c2e7b71d87cc2e21
https://doi.org/10.1016/j.neuroscience.2014.10.005
https://doi.org/10.1016/j.neuroscience.2014.10.005
Autor:
Angela K. Walker, Noelle S. Williams, Joseph M. Ready, Ruth Starwalt, Jen Chieh Chuang, Sandi Jo Estill, Jeffrey M. Zigman, Paula Huntington, Stephanie Tran, Lorraine Morlock, Amelia J. Eisch, Sherri Osborne-Lawrence, Jacinth Naidoo, Andrew A. Pieper, Qian Wang, Phillip D. Rivera
Publikováno v:
Molecular Psychiatry. 20:500-508
Augmenting hippocampal neurogenesis represents a potential new strategy for treating depression. Here we test this possibility by comparing hippocampal neurogenesis in depression-prone ghrelin receptor (Ghsr)-null mice to that in wild-type littermate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de5d56bd3b919559ce60b1c59fa72fe
https://doi.org/10.1038/mp.2014.34
https://doi.org/10.1038/mp.2014.34
Autor:
Jacinth Naidoo, Andrew A. Pieper, Paula Huntington, Joseph M. Ready, Noelle S. Williams, Sandi Jo Estill, Lorraine Morlock, Thomas J. Mangano, Ruth Starwalt, Héctor De Jesús-Cortés
Publikováno v:
Journal of Medicinal Chemistry
(−)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ed3e60c75462daace0884797e29c13
https://doi.org/10.1021/jm401919s
https://doi.org/10.1021/jm401919s
Publikováno v:
Educational Technology, 1985 Feb 01. 25(2), 12-14.
Externí odkaz:
https://www.jstor.org/stable/44427013