Polypathologies and Animal Models of Traumatic Brain Injury

Autor: Erin Freeman-Jones, William H. Miller, Lorraine M. Work, Josie L. Fullerton

Publikováno v: Brain Sciences, Vol 13, Iss 12, p 1709 (2023)

Traumatic brain injury (TBI) is an important health issue for the worldwide population, as it causes long-term pathological consequences for a diverse group of individuals. We are yet to fully elucidate the significance of TBI polypathologies, such a

Externí odkaz: https://doaj.org/article/e234cf877d204bbcb7f61e4cf3ec6afc

Systematic review: Association between circulating microRNA expression & stroke

Autor: Josie L Fullerton, Josephine M Thomas, Laura Gonzalez-Trueba, Cara Trivett, Josie C van Kralingen, Stuart M Allan, Terence J Quinn, Lorraine M Work

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 42:935-951

This systematic review aimed to establish the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs, and the use of microRNA expression in the diagnosis and prognosis of ischaemic or haemorrhagic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118d585e23097765a2836ca81027d03d
https://doi.org/10.1177/0271678x221085090

Extracellular vesicles and their microRNA cargo in ischaemic stroke

Autor: Josie L. Fullerton, Caitlin C. Cosgrove, Rebecca A. Rooney, Lorraine M. Work

Publikováno v: The Journal of Physiology.

Acute ischaemic stroke (AIS) is a leading cause of death and disability. MicroRNAs (miRNAs) are short non-coding RNAs which hold the potential to act as a novel biomarker in AIS. The majority of circulating miRNAs are actively encapsulated by extrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68bc902c25d23b8e409aa3221094b2e
https://doi.org/10.1113/jp282050

The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: insight from preclinical stroke studies and therapeutic potential

Autor: Lorraine M. Work, Aisling McFall, Stuart A. Nicklin

Publikováno v: Cellular Signalling

Stroke is the 2nd leading cause of death worldwide and the leading cause of physical disability and cognitive issues. Although we have made progress in certain aspects of stroke treatment, the consequences remain substantial and new treatments are ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f959631fa4ab01749588df72a511465d
https://eprints.gla.ac.uk/223969/2/223969.pdf

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings

Autor: Malcolm R. Macleod, Margaux Aimable, Scott Miners, Matthew MacGregor Sharp, Hilary V O Carswell, Philip M.W. Bath, Ashton Bernard, Emily S. Sena, Claire S. White, Rhian M. Touyz, Patrick G. Kehoe, Tracy D. Farr, Lorraine M. Work, Stefan Szymkowiak, Gillian L. Currie, Catherine N. Hall, Bettina Platt, Andrew N. Clarkson, Gaia Brezzo, Stuart M. Allan, Mark Andrew Good, Roxana O. Carare, Alison D. McNeilly, Alyson A. Miller, Jill H. Fowler, Barry W. McColl, Tuuli M Hietamies, Christopher McCabe, Rebecca C. Trueman, Vincent Mok, Rajesh N. Kalaria, Michael O'Sullivan, Terence J. Quinn, Karen Horsburgh, Atticus H. Hainsworth, Patrick Strangeward, Catherine E. Lawrence, Aisling McFall

Publikováno v: McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, MacLeod, M, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552
Journal of Cerebral Blood Flow & Metabolism
McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J H, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, Macleod, M, McColl, B W, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E S, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eef0fbd3bfb3e2bea0c06634a444e02
https://strathprints.strath.ac.uk/71920/7/McFall_etal_JCBFM_2020_UK_consensus_on_pre_clinical_vascular_cognitive.pdf