Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Lorraine K. Webster"'
Autor:
Julia Schur, Ingo Ott, Anja P Erven, Glen B. Deacon, Axel Klein, Simon Schmitz, Lorraine K. Webster, Carleen Cullinane, Gerd Meyer, Peter C. Junk, Penny R. Drago, Jenny Luu
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 47(6)
New organometallic complexes [M(dppe)(R)2] {where M = Pt or Pd, dppe = 1,2-bis(diphenylphosphano)ethane, and R = C6F4H-x (x = 6,5,4), C6F3H2-3,5, C6F3H2-5,6, C6F3H2-3,6, C6F4(OMe)-4, and C6F4(cyclo-C5H10N)-4, the numbers x refer to the positions of t
Autor:
B. M. Gatehouse, Eric T. Lawrenz, Lorraine K. Webster, Carleen Cullinane, Gary D. Fallon, Silvina Rainone, Lance Kelly, Glen B. Deacon, Alan M. Bond, Andrew R. Battle, Trevor W. Hambley, Dayna N. Mason, Susan A Turland, SiXuan Guo
Publikováno v:
Journal of Inorganic Biochemistry. 115:226-239
The putative platinum(IV) anticancer drugs, [Pt{((R)NCH(2))(2)}(py)(2)XY] (X,Y=Cl, R=p-HC(6)F(4) (1a), C(6)F(5) (1b); X,Y=OH, R=p-HC(6)F(4) (2); X=Cl, Y=OH, R=p-HC(6)F(4) (3), py = pyridine) have been prepared by oxidation of the Pt(II) anticancer dr
Autor:
Michael Millward, A. Yap, Martin Gore, John Zalcberg, M. Copeman, Lorraine K. Webster, Kevin Lynch, Ian N. Olver, Colin M. House, David D.L. Bowtell, Y. Wang, P.S. Cohen
Publikováno v:
British Journal of Cancer
Midostaurin (PKC412A), N-benzoyl-staurosporine, potently inhibits protein kinase C alpha (PKCalpha), VEGFR2, KIT, PDGFR and FLT3 tyrosine kinases. In mice, midostaurin slows growth and delays lung metastasis of melanoma cell lines. We aimed to test m
Autor:
Lorraine K. Webster, Terrance Grant Johns, Maureen Nerrie, Andrew M. Scott, Janet Weinstock, Antony W. Burgess, Roger Murphy, Francesca Walker, G. McLachlan, Alexander Levitzki, M.M. Doherty, Angela A. Vitali, Edouard C. Nice, Andrew G. Ellis
Publikováno v:
Biochemical Pharmacology. 71:1422-1434
The tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (AG1478) is a potent and specific inhibitor of EGFR tyrosine kinase whose favourable preclinical profile supports progression towards clinical trials. Microphysiometric evaluation revealed a
Autor:
Michael Michael, Lorraine K. Webster, Michael J. Millward, Andrew G. Ellis, Kerrie Stokes, Kally Yuen, Danny Rischin, Sherene Loi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 54:407-414
Paclitaxel, when combined with carboplatin, exhibits a platelet-sparing effect. Paclitaxel is formulated in Cremophor EL (CrEL), which has been shown in preclinical models to reduce haematological toxicity from radiotherapy and chemotherapy. We sough
Autor:
K. T. Nelson, Lorraine K. Webster, Carleen Cullinane, Trevor W. Hambley, Penny R. Drago, Glen B. Deacon
Publikováno v:
Journal of Inorganic Biochemistry. 89:293-301
A range of [PtR(2)(chxn)] (R=C(6)F(5), o-HC(6)F(4), p-HC(6)F(4), p-MeOC(6)F(4) or 3,5-H(2)C(6)F(3); chxn=cyclohexane-1,2-diamine) and cis-[PtR(2)(dmso)(2)] (R=C(6)F(5), p-HC(6)F(4) or p-MeOC(6)F(4); dmso=dimethyl sulfoxide) complexes have been prepar
Autor:
Andrew G. Ellis, Ian N. Olver, So-Hyang Park, Lorraine K. Webster, Merrill J. Egorin, Margaret Davy, Diana Lüftner
Publikováno v:
Cancer Chemotherapy and Pharmacology. 48:109-114
Purpose: The efficacy and pharmacokinetics of paclitaxel when combined with altretamine for ovarian cancer were studied. Methods: A group of 30 patients, whose only chemotherapy was one or more cisplatin-based non-paclitaxel-containing regimens and w
Autor:
Alexander Levitzki, E. C. Nice, Antony W. Burgess, Andrew G. Ellis, Lorraine K. Webster, Janet Weinstock
Publikováno v:
Europe PubMed Central
The tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (AG1478) is undergoing evaluation as a potential new anticancer agent. We have developed a specific and sensitive reversed-phase HPLC assay for AG1478 in mouse plasma. The method involves a
Autor:
Lorraine K. Webster, Brian L. Hillcoat, Ian N. Olver, Robert G. Sephton, James F. Bishop, Kerrie H. Stokes
Publikováno v:
Cancer Chemotherapy and Pharmacology. 45:55-58
This study investigated the pharmacokinetics and activity of gallium nitrate in non-small cell lung cancer when 700 mg/m2 was given as a 30-min infusion with prehydration every 2 weeks. Gallium was measured in plasma and urine using flameless atomic
Autor:
Lorraine K. Webster, Vinod Ganju, Prudence A. Francis, Sumith Nawaratne, James F. Bishop, Michael Millward, Guy C. Toner, Danny Rischin
Publikováno v:
Investigational New Drugs. 17:73-80
The objectives of this phase I trial were to determine the maximally tolerated doses of the combination of epirubicin and paclitaxel with and without G-CSF (granulocyte colony stimulating factor) support and to investigate whether epirubicin pharmaco