Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Lorraine J, Gudas"'
Autor:
Rodhan Patke, Anna E. Harris, Corinne L. Woodcock, Rachel Thompson, Rute Santos, Amber Kumari, Cinzia Allegrucci, Nathan Archer, Lorraine J. Gudas, Brian D. Robinson, Jenny L. Persson, Rupert Fray, Jennie Jeyapalan, Catrin S. Rutland, Emad Rakha, Srinivasan Madhusudan, Richard D. Emes, Musalwa Muyangwa-Semenova, Mansour Alsaleem, Simone de Brot, William Green, Hari Ratan, Nigel P. Mongan, Jennifer Lothion-Roy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 56, Iss , Pp 101032- (2024)
Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen
Externí odkaz:
https://doaj.org/article/f224ca60609a48d0bd38942bd1a03543
Autor:
Johannes C. van der Mijn, Kristian B. Laursen, Leiping Fu, Francesca Khani, Lukas E. Dow, Dawid G. Nowak, Qiuying Chen, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs
Externí odkaz:
https://doaj.org/article/663f362a226d470abe3578034e1b34b8
Autor:
Jaclyn M. Kubala, Kristian B. Laursen, Ryan Schreiner, Ryan M. Williams, Johannes C. van der Mijn, Michael J. Crowley, Nigel P. Mongan, David M. Nanus, Daniel A. Heller, Lorraine J. Gudas
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed
Externí odkaz:
https://doaj.org/article/4c9bb11a4e334b73b7320519c6504793
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The 5-year survival rate for patients with oral squamous cell carcinomas (SCC), including tongue SCC, has not significantly improved over the last several decades. Oral potentially malignant disorders (OPMD), including oral dysplasias, are o
Externí odkaz:
https://doaj.org/article/0fe8597c77f845b591ad5ae29a7fcb03
Autor:
Johannes C. van derMijn, Kenneth W. Eng, Pooja Chandra, Evan Fernandez, Sinan Ramazanoglu, Alexandros Sigaras, Clara Oromendia, Lorraine J. Gudas, Scott T. Tagawa, David M. Nanus, Bishoy F. Faltas, Himisha Beltran, Cora N. Sternberg, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Ana M. Molina
Publikováno v:
Molecular Oncology, Vol 16, Iss 12, Pp 2384-2395 (2022)
Primary clear cell renal cell carcinoma (ccRCC) has been previously characterized, but the genomic landscape of metastatic ccRCC is largely unexplored. Here, we performed whole exome sequencing (WES) in 68 samples from 44 patients with ccRCC, includi
Externí odkaz:
https://doaj.org/article/c682ec50c37c498fac15bed303bb33ff
Autor:
Veronika M. Metzler, Simone de Brot, Daisy B. Haigh, Corinne L. Woodcock, Jennifer Lothion-Roy, Anna E. Harris, Emeli M. Nilsson, Atara Ntekim, Jenny L. Persson, Brian D. Robinson, Francesca Khani, Kristian B. Laursen, Lorraine J. Gudas, Michael S. Toss, Srinivasan Madhusudan, Emad Rakha, David M. Heery, Catrin S. Rutland, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types
Externí odkaz:
https://doaj.org/article/a03a643cd6764996be2ac0f2c2df949e
Autor:
Jennifer Lothion-Roy, Daisy B. Haigh, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Michael S. Toss, Yousif Kariri, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Victoria H. James, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Corinne L. Woodcock
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are
Externí odkaz:
https://doaj.org/article/ee16cd5a10274e0e9f3c44999cecb5f8
Autor:
Anna E. Harris, Veronika M. Metzler, Jennifer Lothion-Roy, Dhruvika Varun, Corinne L. Woodcock, Daisy B. Haigh, Chantelle Endeley, Maria Haque, Michael S. Toss, Mansour Alsaleem, Jenny L. Persson, Lorraine J. Gudas, Emad Rakha, Brian D. Robinson, Francesca Khani, Laura M. Martin, Jenna E. Moyer, Juliette Brownlie, Srinivasan Madhusudan, Cinzia Allegrucci, Victoria H. James, Catrin S. Rutland, Rupert G. Fray, Atara Ntekim, Simone de Brot, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic
Externí odkaz:
https://doaj.org/article/cdc6c0e64c544575b4a2feb180c39250
Autor:
Nina Orfali, Deborah Shan‐Krauer, Tracey R. O’Donovan, Nigel P. Mongan, Lorraine J. Gudas, Mary R. Cahill, Mario P. Tschan, Sharon L. McKenna
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1297-1309 (2020)
Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous
Externí odkaz:
https://doaj.org/article/d6f2dd270c9a47d8aa678254a9db298c
Autor:
Johannes C. van der Mijn, Leiping Fu, Francesca Khani, Tuo Zhang, Ana M. Molina, Christopher E. Barbieri, Qiuying Chen, Steven S. Gross, Lorraine J. Gudas, David M. Nanus
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 177-185 (2020)
The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. He
Externí odkaz:
https://doaj.org/article/26b5223318384c0ab3149631b4ea0af2