Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lorraine Irving"'
Autor:
Sophia K. Berry, Steven Rust, Lorraine Irving, Josefin Bartholdson Scott, Lucy A. Weinert, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of Klebsiella pneumoniae. We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, including
Externí odkaz:
https://doaj.org/article/95aa0fb605154b428c64e9bc9b28abc5
Autor:
Simon Dovedi, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Becki Dudley, Marcin Wolny, Seraina Blümli, Ellie Chatzopoulou, Alan Sandercock, Stacy Pryts
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/27c1e65ddcfa42aa9c4332c72d2c1022
Autor:
Sophia K. Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, David E. Tabor, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display
Externí odkaz:
https://doaj.org/article/f5b2bd62c6a24a919b1bf35d4d9e5d1d
Autor:
Darren J. Schofield, Lorraine Irving, Laura Calo, Anna Bogstedt, Gareth Rees, Annalisa Nuccitelli, Rajesh Narwal, Marcella Petrone, Jennifer Roberts, Lee Brown, Fiona Cusdin, Bhupinder Dosanjh, Christopher Lloyd, Claire Dobson, Ian Gurrell, Graham Fraser, Mary McFarlane, Edward Rockenstein, Brian Spencer, Eliezer Masliah, Maria Grazia Spillantini, Keith Tan, Andrew Billinton, Tris Vaughan, Iain Chessell, Michael S. Perkinton
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed throughout the nervous system in PD. α-Synuclein is a core component of Lewy
Externí odkaz:
https://doaj.org/article/a43f225941e34147934ac245763e71a0
Autor:
Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112109 (2014)
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose c
Externí odkaz:
https://doaj.org/article/b7aa8b820e4f483cb303314c37c5602a
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
Supplementary Materials and Methods, and Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037
https://doi.org/10.1158/2159-8290.22540037
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263
https://doi.org/10.1158/2159-8290.c.6549263
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca36b45e55f3b372d826ed6a15c12039
https://doi.org/10.1158/2159-8290.cd-20-1445
https://doi.org/10.1158/2159-8290.cd-20-1445
Autor:
Sophia K, Berry, Steven, Rust, Carolina, Caceres, Lorraine, Irving, Josefin, Bartholdson Scott, David E, Tabor, Gordon, Dougan, Graham, Christie, Paul, Warrener, Ralph, Minter, Andrew J, Grant
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db63f1468dccdec106edcc027948041b
https://pubmed.ncbi.nlm.nih.gov/34923908
https://pubmed.ncbi.nlm.nih.gov/34923908
Autor:
Hannes Lindahl, M Lindén, Karolina Tandre, Sahl Khalid Bedri, Mohsen Khademi, Lars Alfredsson, Colin P. Glover, André Ortlieb Guerreiro-Cacais, Maja Jagodic, Mathias Linnerbauer, Ingrid Kockum, Lars Rönnblom, Tomas Olsson, Lorraine Irving, Clare A. Jones, Nada Abdelmagid, Claire Hollins
Publikováno v:
The Journal of Immunology. 203:888-898
Genome-wide association studies have mapped the specific sequence variants that predispose for multiple sclerosis (MS). The pathogenic mechanisms that underlie these associations could be leveraged to develop safer and more effective MS treatments bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b57ed0a1b95786d58a161fe602a2ef6
https://doi.org/10.4049/jimmunol.1900400
https://doi.org/10.4049/jimmunol.1900400