Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Lorraine Iacovitti"'
Autor:
Lara Cheslow, Matthew Byrne, Jessica S. Kopenhaver, Lorraine Iacovitti, Richard J. Smeyne, Adam E. Snook, Scott A. Waldman
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron death in Parkinson’s disease (PD). Guanylyl cyclases and their second
Externí odkaz:
https://doaj.org/article/875aeffe76714a2baa47bb9bad8684dd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/c87ecaec6b19468bb0a68bbe6f16948a
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102332- (2021)
When studying patient specific induced pluripotent stem cells (iPS cells) as a disease model, the ideal control is an isogenic line that has corrected the point mutation, instead of iPS cells from siblings or other healthy subjects. However, repairin
Externí odkaz:
https://doaj.org/article/66ac66f6087e41d182a92fca6e547270
Autor:
Ruihe Lin, Michael Lang, Nicolette Heinsinger, Geoffrey Stricsek, Justine Zhang, Renato Iozzo, Robert Rosenwasser, Lorraine Iacovitti
Publikováno v:
Neurobiology of Disease, Vol 115, Iss , Pp 49-58 (2018)
Stroke patients are at increased risk for recurrent stroke and development of post-stroke dementia. In this study, we investigated the effects of recurrent stroke on adult brain neurogenesis using a novel rat model of recurrent middle cerebral artery
Externí odkaz:
https://doaj.org/article/92bffde18008448ca65a2130cd618fca
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared. Mechani
Externí odkaz:
https://doaj.org/article/2c0637ca2eec48a49e4f470402a89e15
Autor:
Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 295-306 (2017)
Summary: The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K2
Externí odkaz:
https://doaj.org/article/5bd388368332412081472e38aff5b32a
Autor:
Thomas Westergard, Brigid K. Jensen, Xinmei Wen, Jingli Cai, Elizabeth Kropf, Lorraine Iacovitti, Piera Pasinelli, Davide Trotti
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 645-652 (2016)
Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat-associated non-ATG tr
Externí odkaz:
https://doaj.org/article/2e4fc1c1a2374d1da63375d78adcbdcb
Autor:
Chia-Hsuan Fu, Daniel Maxim Iascone, Iraklis Petrof, Anupam Hazra, Xiaohong Zhang, Mark S. Pyfer, Umberto Tosi, Brian F. Corbett, Jingli Cai, Jason Lee, Jin Park, Lorraine Iacovitti, Helen E. Scharfman, Grigori Enikolopov, Jeannie Chin
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3741-3751.e4 (2019)
Summary: Adult hippocampal neurogenesis has been reported to be decreased, increased, or not changed in Alzheimer’s disease (AD) patients and related transgenic mouse models. These disparate findings may relate to differences in disease stage, or t
Externí odkaz:
https://doaj.org/article/c68c105cb2284c3eab73a4511c407eb6
Autor:
Thana N. Theofanis, Ankit K. Rochani, Richard F. Schmidt, Michael J. Lang, Geoffrey P. Stricsek, Robert H. Rosenwasser, Ashwini D. Sharan, Gagan Kaushal, Lorraine Iacovitti
Publikováno v:
Scientia Pharmaceutica, Vol 88, Iss 3, p 40 (2020)
Sphenopalatine ganglion (SPG) stimulation has been shown to reversibly alter blood-brain barrier (BBB) permeability. It is widely used for the treatment of cluster headaches in Europe and is well tolerated in humans. The therapeutic potential for SPG
Externí odkaz:
https://doaj.org/article/9c1fb47fd29b4e1d85f59150d4136a3b
Autor:
Ruihe Lin, Jingli Cai, Cody Nathan, Xiaotao Wei, Stephanie Schleidt, Robert Rosenwasser, Lorraine Iacovitti
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 229-239 (2015)
Previous studies have established the subventricular (SVZ) and subgranular (SGZ) zones as sites of neurogenesis in the adult forebrain (Doetsch et al., 1999a; Doetsch, 2003a). Work from our laboratory further indicated that midline structures known a
Externí odkaz:
https://doaj.org/article/e08c3f8e67fa400a89b5b1dfbbd0ec31