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pro vyhledávání: '"Lorraine Hanssen"'
Publikováno v:
Cellular Immunology. 224:74-85
Memory and effector T cells modulate subsequently primed T cell responses to the same antigen. However, little is known about the impact of pre-existing memory and effector T cell immunity on subsequently primed immune responses to unrelated antigens
Publikováno v:
The Journal of Immunology. 167:1081-1089
B cells can serve dual roles in modulating T cell immunity through their potent capacity to present Ag and induce regulatory tolerance. Although B cells are necessary components for the initiation of spontaneous T cell autoimmunity to β cell Ags in
Publikováno v:
Immunology today. 20(4)
Insights into tolerance and autoimmune processes have led to novel immunotherapeutics for inhibiting autoimmune disease in animal models. However, recent studies question the immune basis of some of these therapeutic strategies and raise concerns abo
Autor:
Dan Zekzer, Blake Middleton, Angelica P. Olcott, Daniel L. Kaufman, Lorraine Hanssen, Jide Tian
Publikováno v:
Immunological reviews. 164
In the non-obese diabetic (NOD) mouse, a Th1-biased autoimmune response arises spontaneously against glutamic acid decarboxylase, concurrent with the onset of insulitis. Subsequently, Th1-type autoreactivity spreads intra- and intermolecularly to oth