Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Lorraine H. Kligman"'
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 16:224-228
It is well known that photoaged skin is characterized by increases in dermal matrix components that include glycosaminoglycans, proteoglycans and masses of abnormal elastic fibers accompanied by substantial collagen loss. Histochemical staining of su
Autor:
Lorraine H. Kligman, EH Gans
Publikováno v:
Journal of Dermatological Treatment. 11:47-52
BACKGROUND: All-trans-retinol was the first vitamin to be synthesized in the laboratory. Dermatologic research with this agent, first begun in the 1960s, was discontinued because of its instability. Investigations since then have focused primarily on
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 15:198-204
We have proposed that UV activation of cytokine and integrin signaling pathways may initiate the photoaging process and that one of the effects of tretinoin treatment may be to alter the cytokine and integrin patterns. In previous results, steady-sta
Publikováno v:
Journal of Dermatological Treatment. 10:37-45
The treatment of photoaged human skin by chemical peeling has become increasingly popular in recent decades. Controlled studies with facial biopsies to assess histologic effects are understandably limited. Animal studies have been on normal rather th
Publikováno v:
Contact Dermatitis. 39:231-239
Laboratory tests to assess the irritant potential of materials, such as skin cleansers, which are normally used over a long period by humans, fail to mimic actual use. Most washing tests last a few days or at most a few weeks. Skin sites and techniqu
Autor:
Lorraine H. Kligman, Marilyn J. Crosby
Publikováno v:
Cancer Letters. 107:217-222
The role of retinoids in hairless mouse photocarcinogenesis has been studied extensively but remains controversial. By contrast, the role of corticosteroids has hardly been investigated. Many findings indicate an antagonism between the action of thes
Publikováno v:
Archives of Dermatological Research. 288:615-620
Tretinoin has been shown to stimulate the synthesis of collagen in photo-aged human and hairless mouse skin. It has been suggested that this partial reversal of photodamage by tretinoin is a consequence of low-grade inflammation. The purpose of this
Autor:
George F. Murphy, Lorraine H. Kligman
Publikováno v:
Archives of Dermatological Research. 288:537-542
In previous studies we have noted that mast cells are increased in tretinoin-treated photoaged hairless mouse skin. Because UV radiation is known to increase mast cell numbers, we were interested in whether tretinoin alone would modulate the mast cel
Autor:
Lorraine H. Kligman, Elaine Schwartz
Publikováno v:
Journal of Investigative Dermatology. 104:518-522
Topical tretinoin treatment of photoaged hairless mice has been shown in previous studies to stimulate formation of a subepidermal zone of new connective tissue characterized by enhanced collagen synthesis. The aims of this study were to localize and