Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lorraine F. Lanyon"'
Autor:
Erica Dresselhaus, James M Duerr, Fabien Vincent, Emily K Sylvain, Mercedes Beyna, Lorraine F Lanyon, Erik LaChapelle, Martin Pettersson, Kelly R Bales, Gayathri Ramaswamy
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194661 (2018)
Despite the important role of apolipoprotein E (apoE) secretion from astrocytes in brain lipid metabolism and the strong association of apoE4, one of the human apoE isoforms, with sporadic and late onset forms of Alzheimer's disease (AD) little is kn
Externí odkaz:
https://doaj.org/article/214aaa2673324b92bf01f2321f37451d
Autor:
Claire M. Steppan, Hui Zhang, Lisa Aschenbrenner, Chang Liu, Lucien P. Ghislain, Lorraine F. Lanyon, Stephen Noell, Mike West, Jianhua Liu, Thomas R. Covey, Matthew D. Troutman, Kenneth J. DiRico, Wenyi Hua, Sammy S Datwani, Don W. Arnold
Publikováno v:
Analytical chemistry. 93(31)
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a transformative system enabl
Autor:
Heather Eng, Annaliesa S. Anderson, Norimitsu Shirai, Brandon J. Anson, James Logue, Stuart Weston, Marisa McGrath, Martyn D. Ticehurst, Rebecca E. O’Connor, Michelle Rossulek, Martin Pettersson, Matthew N O' Brien, Jean G. Sathish, Matthew B. Frieman, Emi Kimoto, Jun Wang, R. Scott Obach, Emily I. Chen, Robert Haupt, Yuao Zhu, Thomas F. Rogers, Andrew D. Mesecar, Suman Luthra, Adolfo García-Sastre, Dafydd R. Owen, Rhys M. Jones, Eugene P. Kadar, Chunlong Ma, Rob Kania, Lisa Aschenbrenner, Arnab K. Chatterjee, Charlotte Moira Norfor Allerton, Joseph John Binder, Kevin Ogilvie, Holly L. Hammond, Nathan Beutler, Claire M. Steppan, Jennifer Hammond, Stephen Noell, Romel Rosales, Robert M. Hoffman, Lillis Jonathan Richard, Matthew R. Reese, Stephen W. Mason, Dan Arenson, Malina A. Bakowski, Lawrence W. Updyke, Lorraine F. Lanyon, Kris M. White, Emma K. Lendy, Melanie G. Kirkpatrick, Britton Boras
Publikováno v:
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. PF-00835231, a 3CL protease inhibitor, has exhibit
Autor:
Emma K. Lendy, Martyn D. Ticehurst, Robert Steven Kania, Lisa Aschenbrenner, Chuang Ma, Michelle Rossulek, Emily I. Chen, Charlotte Moira Norfor Allerton, Rhys M. Jones, Stephen W. Mason, Kevin Ogilvie, Heather Eng, Dan Arenson, Lorraine F. Lanyon, Abhishek Chatterjee, Rob Haupt, Martin Pettersson, Britton Boras, Eugene P. Kadar, Malina A. Bakowski, Yuao Zhu, Obach Rs, Suman Luthra, Stuart Weston, Joseph John Binder, Lillis, Stephen Noell, Thomas F. Rogers, Dafydd R. Owen, O’Brien Mn, Claire M. Steppan, Lawrence W. Updyke, Jennifer Hammond, Jun Wang, Norimitsu Shirai, Brandon J. Anson, Nathan Beutler, Jean G. Sathish, Melanie G. Kirkpatrick, Annaliesa S. Anderson, James Logue, Matthew B. Frieman, Andrew D. Mesecar, Holly L. Hammond, Robert M. Hoffman, Reese Mr, Marisa McGrath, Rebecca E. O’Connor, Emi Kimoto
Publikováno v:
Nature Communications
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. PF-00835231, a 3CL protease inhibitor, has exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bedafdf92a23451d3e8b9574a30f85
https://doi.org/10.1101/2020.09.12.293498
https://doi.org/10.1101/2020.09.12.293498
Autor:
Don W. Arnold, Jianhua Liu, Chang Liu, Lucien P. Ghislain, Lisa Aschenbrenner, Lorraine F. Lanyon, Matthew D. Troutman, Wenyi Hua, Stephen Noell, Claire M. Steppan, Hui Zhang, Thomas R. Covey, Kenneth J. DiRico, Sammy S Datwani
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI) MS that creates a transformative system enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703c8556217136f2c5ea488b12069005
Autor:
Erica C. Dresselhaus, Leah Cleary, Gayathri Ramaswamy, Michael Marconi, Patrick Robert Verhoest, Edel Evrard, Uthpala Seneviratne, Christopher amEnde, Martin Pettersson, Ethan Lawrence Fisher, Jamison B. Tuttle, Lorraine F. Lanyon, Longfei Xie, Emily Sylvain, Travis T. Wager, Butler Todd W, John M. Humphrey, Claire M. Steppan, Simone Sciabola, Douglas Scott Johnson, Zhen Huang, Christopher J Helal, Michael Eric Green, Paramita Mukherjee
Publikováno v:
SSRN Electronic Journal.
Apolipoprotein E (apoE) is a 34 kDa key lipid transport protein in both the brain and the periphery. In the brain, it is produced predominantly by astrocytes and has been shown to play an important role in promoting neurite outgrowth and synaptogenes
Autor:
Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck
Publikováno v:
Journal of Medicinal Chemistry. 61:4476-4504
A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease is the alignment of potency, drug-like properties, and selectivity over related aspartyl proteases
Autor:
Felix Vajdos, Eric Benvenuti, Leanne M. Buzon, Brian T. O’Neill, Gabriela Barreiro, David Riddell, Kevin Atchison, Charles E. Nolan, Ashley Robshaw, Eric F. Johnson, Kevin D. Parris, Shawn D. Doran, Michael Aaron Brodney, Xinjun Hou, Luis Martinez-Alsina, Kimberly Lapham, Mei-Hui Hsu, Elizabeth Mary Beck, Christopher Ryan Butler, Kevin Ogilvie, Cathleen Gonzales, Lorraine F. Lanyon, Christopher John Helal
Publikováno v:
Journal of Medicinal Chemistry
A growing subset of β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease (AD) utilizes an anilide chemotype that engages a key residue (Gly230) in the BACE1 binding site. Although the anilide moiety affords excellent potency, it s
Autor:
Christopher W. am Ende, Ethan Lawrence Fisher, Erica C. Dresselhaus, Leah Cleary, John M. Humphrey, Edelweiss Evrard, Douglas S. Johnson, Patrick Robert Verhoest, Jamison B. Tuttle, Travis T. Wager, Longfei Xie, Emily Sylvain, Zhen Huang, Martin Pettersson, Uthpala Seneviratne, Lorraine F. Lanyon, Michael Marconi, Claire M. Steppan, Gayathri Ramaswamy, Simone Sciabola, Christopher John Helal, Michael Eric Green, Butler Todd W, Paramita Mukherjee
Publikováno v:
Cell Chem Biol
Summary Utilizing a phenotypic screen, we identified chemical matter that increased astrocytic apoE secretion in vitro. We designed a clickable photoaffinity probe based on a pyrrolidine lead compound and carried out probe-based quantitative chemical
Autor:
Steven H. Liang, Jinshan Michael Chen, Marc D. Normandin, Jeanne S. Chang, George C. Chang, Christine K. Taylor, Patrick Trapa, Mark S. Plummer, Kimberly S. Para, Edward L. Conn, Lori Lopresti‐Morrow, Lorraine F. Lanyon, James M. Cook, Karl E. G. Richter, Charlie E. Nolan, Joel B. Schachter, Fouad Janat, Ye Che, Veerabahu Shanmugasundaram, Bruce A. Lefker, Bradley E. Enerson, Elijahu Livni, Lu Wang, Nicolas J. Guehl, Debasis Patnaik, Florence F. Wagner, Roy Perlis, Edward B. Holson, Stephen J. Haggarty, Georges El Fakhri, Ravi G. Kurumbail, Neil Vasdev
Publikováno v:
Angewandte Chemie. 128:9753-9757