Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lorraine A, DeGiorgio"'
Autor:
John P. Blass, Kwan-Fu Rex Sheu, Zbigniew Darzynkiewicz, Ronald S. Black, Lorraine A. DeGiorgio, Janet T. Duffy
Publikováno v:
Journal of Neurochemistry. 62:2132-2140
Cells have been cultured from the brains of 60-day-old rats and propagated through 12 passages. The cells contain the high and middle, but not low, molecular weight neurofilament subunits and neuron-specific enolase, demonstrated by immunoblotting an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b915e027df132e446f420260b06a0e4c
https://doi.org/10.1046/j.1471-4159.1994.62062132.x
https://doi.org/10.1046/j.1471-4159.1994.62062132.x
Autor:
Lorraine A. DeGiorgio, David Pechman, Saravanan S. Karuppagounder, Gary E. Gibson, Hui Xu, Lian H. Chen
Publikováno v:
Neurochemical Research. 33:1365-1372
Thiamine deficiency (TD) is a model of neurodegeneration induced by mild impairment of oxidative metabolism. TD produces time-dependent glial activation, inflammation, oxidative stress, altered metabolism of amyloid precursor protein (APP), exacerbat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b948f8c5b3a1dc1448d0eaffbbddcf7
https://doi.org/10.1007/s11064-008-9594-z
https://doi.org/10.1007/s11064-008-9594-z
Autor:
Mark A. Edgar, Czeslawa Kowal, Bruce T. Volpe, Patricio T. Huerta, Lorraine A. DeGiorgio, Betty Diamond, Ji Y. Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19854-19859
Neuropsychiatric systemic lupus erythematosus, which often entails cognitive disturbances and memory loss, has become a major complication for lupus patients. Previously, we developed a murine model of neuropsychiatric lupus based on Abs that cross-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa862bd66c4ba85aefa8030ffb403fb
https://doi.org/10.1073/pnas.0608397104
https://doi.org/10.1073/pnas.0608397104
Publikováno v:
Proceedings of the National Academy of Sciences. 103:678-683
Systemic lupus erythematosus is an autoimmune disease in which most patients express Abs that bind double-stranded DNA. Recent work has shown that a subset of lupus Abs can crossreact with the NR2A and NR2B subunits of the NMDA receptor. This recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26616d89afde769de92d62e992ce277
https://doi.org/10.1073/pnas.0510055103
https://doi.org/10.1073/pnas.0510055103
Autor:
Myung S. Yoo, Soo-Youl Kim, Chu Peng, Jin H. Son, Hibiki Kawamata, Hui Zhang, Young K. Lee, M. Flint Beal, David Sulzer, Lichuan Yang, Ted M. Dawson, Dae J. Kim, Hong S. Chun, Lorraine A. DeGiorgio, Harriet Baker
Publikováno v:
Journal of Neurochemistry. 94:1040-1053
Septin 5, a parkin substrate, is a vesicle- and membrane-associated protein that plays a significant role in inhibiting exocytosis. The regulatory function of Septin 5 in dopaminergic (DAergic) neurons of substantia nigra (SN), maintained at relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4c387e8970fe98f717b64ed2d28ebf
https://doi.org/10.1111/j.1471-4159.2005.03257.x
https://doi.org/10.1111/j.1471-4159.2005.03257.x
Autor:
Betty Diamond, Tsukasa Nakaoka, Bruce T. Volpe, Lorraine A. DeGiorgio, Czeslawa Kowal, Patricio T. Huerta, Hoby P. Hetherington
Publikováno v:
Immunity. 21:179-188
Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS vascular disease or inflammation. SLE patients produce anti-DNA antibodies that crossreact with NMDA receptors and are capable of mediating excitotoxic death. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e058abee01cf91cf8e7ff2babfe734b5
https://doi.org/10.1016/j.immuni.2004.07.011
https://doi.org/10.1016/j.immuni.2004.07.011
Publikováno v:
Neuroscience. 129:831-839
It has been demonstrated that tyrosine hydroxylase (TH) gene is easily regulated in the CNS as well as peripheral nervous systems by stressful conditions. The stimuli, such as stress or reserpine administration, significantly increased the TH gene in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e2914bf8be07934aba994d44125e1d
https://doi.org/10.1016/j.neuroscience.2004.08.024
https://doi.org/10.1016/j.neuroscience.2004.08.024
Autor:
Shuei Sugama, Bruce T. Volpe, Byung Pil Cho, D.H Shin, Yoon Seong Kim, Donald J. Reis, S.S Kim, Lorraine A. DeGiorgio, Sunghee Cho, Tong H. Joh, Yoshinori Shimizu
Publikováno v:
Neuroscience. 116:925-933
Dopaminergic neurons in the substantia nigra pars compacta undergo apoptosis after transection of the medial forebrain bundle. We have assessed the temporal and sequential activities of microglia in these events by examining the complement-3 (OX-42),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d02b6b67d219ccefe8ae99ff1c9ab0c
https://doi.org/10.1016/s0306-4522(02)00572-9
https://doi.org/10.1016/s0306-4522(02)00572-9
Autor:
Shuei Sugama, Bruce T. Volpe, Tong H. Joh, Dong H. Shin, Sunghee Cho, Yoon Seong Kim, Sung Soo Kim, So Young Lim, Byung Pil Cho, Lorraine A. DeGiorgio, Key Chung Park
Publikováno v:
Cellular and Molecular Neurobiology. 23:551-560
Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2c934fedbc6ea7c2960681ff7c4c6e
https://doi.org/10.1023/a:1025024129946
https://doi.org/10.1023/a:1025024129946
Autor:
Bruce T. Volpe, Yoon Seong Kim, Shuei Sugama, Tong H. Joh, Jin H. Son, Lorraine A. DeGiorgio, Yoshinori Shimizu, Hong S. Chun
Publikováno v:
Brain Research. 938:38-44
Our past work has shown that the C-terminal fragment of amyloid precursor protein (APP) translocated to the nucleus in neurons destined for delayed excitotoxic degeneration. To test whether nuclear APP fragments also play a role in the progressive lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51b55dff496705059c50a577b92deee
https://doi.org/10.1016/s0006-8993(02)02483-6
https://doi.org/10.1016/s0006-8993(02)02483-6