Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Lorraine, Robb"'
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Autor:
Amy R. Rappaport, Johannes Zuber, Erinna F. Lee, Lorraine Robb, Evelyn Trounson, Stefan P Glaser, Andrew H. Wei, Scott W. Lowe, David J. Izon, Andreas Strasser, Warren S. Alexander, W. Douglas Fairlie, Marco J Herold, Philippe Bouillet
Publikováno v:
Genes & Development. 26:120-125
Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-xL and Mcl-1. Here we report that removal of Mcl-1, but not loss or pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65af05da566adcdb48d0d83c10c19a55
https://doi.org/10.1101/gad.182980.111
https://doi.org/10.1101/gad.182980.111
Publikováno v:
The Journal of Immunology. 187:6318-6326
B cell behavior is fine-tuned by internal regulatory mechanisms and external cues such as cytokines and chemokines. Suppressor of cytokine signaling 3 (SOCS3) is a key regulator of STAT3-dependent cytokine responses in many cell types and has been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0fc44133734742a78ef5306dc3657a
https://doi.org/10.4049/jimmunol.1102057
https://doi.org/10.4049/jimmunol.1102057
Autor:
David A.F. Loebel, Vanessa Jones, Melinda Power, Kirsten A. Steiner, Lorraine Robb, Leigh Coultas, Renuka S. Rao, Nicolas Fossat, Patrick P.L. Tam, Yvette Jackson, Joshua B. Studdert, Tania Radziewic
Publikováno v:
Small GTPases
Rhou encodes a Cdc42-related atypical Rho GTPase that influences actin organization in cultured cells. In mouse embryos at early-somite to early-organogenesis stages, Rhou is expressed in the columnar endoderm epithelium lining the lateral and ventra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d5a4ada6afb601724b8dcecfc346ad
https://doi.org/10.1242/dev.063867
https://doi.org/10.1242/dev.063867
Autor:
Lin Tai, Lorraine A. O Reilly, W. Douglas Fairlie, Stephanie Grabow, Lorraine Robb, Philippe Bouillet, Lily Lee, David M. Tarlinton, Jian-Guo Zhang, Gabrielle T. Belz, Andreas Strasser, Nicole M. Haynes, Elizabeth A. Kruse, Mark J. Smyth
Publikováno v:
Nature. 461:659-663
Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity. Accordingly, mutations in their genes cause severe lymphadenopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183358c8fba714797b6d2a71465e480b
https://doi.org/10.1038/nature08402
https://doi.org/10.1038/nature08402
Publikováno v:
Biology of Reproduction. 80:920-927
Hormonal contraceptives are unsuitable for many women; thus, the development of new, nonhormonal contraceptives is of great interest. In women, uterine epithelial expression of interleukin 11 (IL11) and its receptor (IL11RA) suggests IL11 is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6258f0d4f5ecd9a232c0be320943e38
https://doi.org/10.1095/biolreprod.108.073601
https://doi.org/10.1095/biolreprod.108.073601
Autor:
Heiner Westphal, Robyn V. Jamieson, Lorraine Robb, Chris Wilcock, Mahua Mukhopadhyay, Poh-Lynn Khoo, Patrick P.L. Tam, Samara L. Lewis, Kirsten A. Steiner, R. Andrea De Young
Publikováno v:
Development. 135:1791-1801
Loss of Dkk1 results in ectopic WNT/β-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f63bdde4fee7ffc37ff7bcf6437706b
https://doi.org/10.1242/dev.018853
https://doi.org/10.1242/dev.018853
Autor:
Neville D. Yeomans, Cameron B. Jackson, Louise M. Judd, Lorraine Robb, Alex Boussioutas, Andrew S. Giraud, Ian Kronborg, C Dow, Trevelyan R. Menheniott
Publikováno v:
The Journal of Pathology. 213:140-151
H. pylori infection accounts for most cases of gastric cancer, but the initiating events remain unclear. The principal H. pylori pathogenicity-associated CagA protein disrupts intracellular SHP-2 signalling pathways including those used by the IL-6 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af070984b78eec9804607b38e7e2301b
https://doi.org/10.1002/path.2218
https://doi.org/10.1002/path.2218
Autor:
Lorraine Robb, Jacqueline van der Wees, Frank Grosveld, Geoffrey J. Lindeman, Mark Shackleton, Marie Liesse Asselin-Labat, Kate D. Sutherland, Jane E. Visvader, Holly E. Barker, Richard M. Thomas, Lynne Hartley, Natasha C. Forrest
Publikováno v:
Nature Cell Biology, 9(2), 201-U103. Nature Publishing Group
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored its normal function within the mammary gland b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641ed6e3ce1bd04b56c7492345341e4f
https://doi.org/10.1038/ncb1530
https://doi.org/10.1038/ncb1530
Autor:
Lorraine Robb, Marilyn Ibrahim, Leendert H.J. Looijenga, Chung Wo Chow, Adam H. Hart, Lynne Hartley, Karen M. Parker, Marija Pauchnik
Publikováno v:
Cancer. 104:2092-2098
BACKGROUND The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe656ef811f0714907024c28741729c3
https://doi.org/10.1002/cncr.21435
https://doi.org/10.1002/cncr.21435
Publikováno v:
Biochemical and Biophysical Research Communications. 333:1361-1369
Mixl1 is a paired-type homeodomain protein that plays a crucial role in morphogenesis and endoderm differentiation in the murine embryo. To understand how Mixl1 directs embryogenesis, we studied the regulation of Mixl1 expression at a transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44d61d4341a13c6fadadd560287edfb
https://doi.org/10.1016/j.bbrc.2005.06.044
https://doi.org/10.1016/j.bbrc.2005.06.044