Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor

Autor: Lornella Seeneevassen, Anissa Zaafour, Elodie Sifré, Coralie Genevois, Tra Ly Nguyen, Yasmine Pobiedonoscew, Alban Giese, Jérôme Guignard, Camille Tiffon, Benoit Rousseau, Anne-Aurélie Raymond, Geneviève Belleannée, Hélène Boeuf, Caroline Gronnier, Océane C. B. Martin, Julie Giraud, Philippe Lehours, Pierre Dubus, Christine Varon

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract Gastric cancer’s (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs are able to initiate metastasis. Targeting these aggressive

Externí odkaz: https://doaj.org/article/f3c91b91bd3d4c56a8a9fbd0497898b6

TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties

Autor: Camille Tiffon, Julie Giraud, Silvia Elena Molina-Castro, Sara Peru, Lornella Seeneevassen, Elodie Sifré, Cathy Staedel, Emilie Bessède, Pierre Dubus, Francis Mégraud, Philippe Lehours, Océane C.B. Martin, Christine Varon

Publikováno v: Cells, Vol 9, Iss 6, p 1462 (2020)

Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo pathway effectors yes-associa

Externí odkaz: https://doaj.org/article/1561b2b429034b62a76430f8af6d91bd

Leukaemia inhibitory factor in gastric cancer: friend or foe?

Autor: Lornella Seeneevassen, Océane C. B. Martin, Philippe Lehours, Pierre Dubus, Christine Varon

Publikováno v: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 25(2)

IL-6 family cytokine leukaemia inhibitory factor (LIF) study has deciphered a variety of effects, in physiology as well as pathology. Despite the sudden arousal in LIF interest in cancers, its study in the gastric cancer (GC) context has been put asi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f931ee7195b43a794d420572ee3a1fe9
https://pubmed.ncbi.nlm.nih.gov/35106710

Helicobacters and cancer, not only gastric cancer?

Autor: Pirjo Spuul, Christine Varon, Armelle Ménard, Lornella Seeneevassen, Sadia Khalid, Lamia Azzi-Martin

Publikováno v: Seminars in cancer biology. 86(Pt 2)

The Helicobacter genus actually comprises 46 validly published species divided into two main clades: gastric and enterohepatic Helicobacters. These bacteria colonize alternative sites of the digestive system in animals and humans, and contribute to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa11b45d9d3bf96ed646a80fa4d6733
https://pubmed.ncbi.nlm.nih.gov/34425210

Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer

Autor: Océane C B Martin, Cathy Staedel, Philippe Lehours, Julie Giraud, Silvia Molina-Castro, Camille Tiffon, Elodie Sifré, Clémentine Beauvoit, Lornella Seeneevassen, Hélène Boeuf, Francis Mégraud, Pierre Dubus, Christine Varon

Publikováno v: Cancers
Cancers, 2020, 12 (8), pp.2011. ⟨10.3390/cancers12082011⟩
Volume 12
Issue 8
Cancers, MDPI, 2020, 12 (8), pp.2011. ⟨10.3390/cancers12082011⟩
Cancers (Basel), vol.12(8), pp.1-24
Kérwá
Universidad de Costa Rica
instacron:UCR
Cancers, Vol 12, Iss 2011, p 2011 (2020)

Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour maintenance and recurrence, making their targeting of utmost importance in gastric cancer (GC) therapy. The Hippo pathway has been implicated in gastric CSC propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d6c5fcbacafb17345f5f86f812f39c
https://doi.org/10.3390/cancers12082011