The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis

Autor: Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript

Externí odkaz: https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c

IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

Autor: Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic

Publikováno v: mBio, Vol 11, Iss 5 (2020)

ABSTRACT In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virul

Externí odkaz: https://doaj.org/article/a8826e64d46d4f19bb5e464319b44f8e

Spoken communication and patient safety: a new direction for healthcare communication policy, research, education and practice?

Autor: Rick Iedema, Rebecca Lawton, Trish Greenhalgh, Stephen Timmons, Joan Russell, John Alexander, Khudeja Amer-Sharif, Paul Gardner, Mark Juniper, Ravi Prakash Mahajan, Priscilla McGuire, Celia Roberts, Wayne Robson, Lorna Wilkinson

Publikováno v: BMJ Open Quality, Vol 8, Iss 3 (2019)

Externí odkaz: https://doaj.org/article/0f1b87c1ee5641aa858dae92411ffd78

Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics.

Autor: Camilla Faoro, Lorna Wilkinson-White, Ann H Kwan, Sandro F Ataide

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200387 (2018)

Given the increasing incidence of antibiotic resistance, antibiotics that employ new strategies are urgently needed. Bacterial survival is dependent on proper function of the signal recognition particle (SRP) and its receptor (FtsY). A unique set of

Externí odkaz: https://doaj.org/article/871e5233b4724d3faff77029b9419d2e

Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia

Autor: Rebecca Williams, Stephanie Jobling, Andrew H. Sims, Chunyan Mou, Lorna Wilkinson, Giovanna M. Collu, Charles H. Streuli, Andrew P. Gilmore, Denis J. Headon, Keith Brennan

Publikováno v: Williams, R, Jobling, S, Sims, A H, Mou, C, Wilkinson, L, Collu, G M, Streuli, C H, Gilmore, A P, Headon, D J & Brennan, K 2021, ' Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia ', Oncogene . https://doi.org/10.1038/s41388-021-01902-6

Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and cutaneous glands. Here we report that human Oestrogen Receptor (ER) negative brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a194eb2099742e6123e1543b9d9df3
https://doi.org/10.1038/s41388-021-01902-6