Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Lorna W. Role"'
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114009- (2024)
Summary: To better understand the function of cholinergic projection neurons in the ventral pallidum (VP), we examined behavioral responses to appetitive (APP) and aversive (AV) odors that elicited approach or avoidance, respectively. Exposure to eac
Externí odkaz:
https://doaj.org/article/12a643861538467dbf35ec7e1f143c46
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of glutamatergic transmission in cortico-limbic circuits. By imaging gene
Externí odkaz:
https://doaj.org/article/840f47ec5e4b4da7bdacb2d8a561408d
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 6 (2014)
Acetylcholine (ACh) signaling underlies specific aspects of cognitive functions and behaviors, including attention, learning, memory and motivation. Alterations in ACh signaling are involved in the pathophysiology of multiple neuropsychiatric disorde
Externí odkaz:
https://doaj.org/article/486e1b8fa4dc476ab8552d223e508e41
Publikováno v:
IEEE Transactions on Visualization and Computer Graphics. 29:1625-1637
Recent advances in high-resolution microscopy have allowed scientists to better understand the underlying brain connectivity. However, due to the limitation that biological specimens can only be imaged at a single timepoint, studying changes to neura
Publikováno v:
Nature Reviews Neuroscience. 24:233-251
Autor:
Lorna W. Role, Parmida Ghahremani, David A. Talmage, Chetan Gudisagar, Saeed Boorboor, Arie E. Kaufman, Mala Ananth, Pooya Mirhosseini
Publikováno v:
IEEE Transactions on Visualization and Computer Graphics. 28:4951-4965
We introduce NeuroConstruct, a novel end-to-end application for the segmentation, registration, and visualization of brain volumes imaged using wide-field microscopy. NeuroConstruct offers a Segmentation Toolbox with various annotation helper functio
Autor:
Richard B Crouse, Kristen Kim, Hannah M Batchelor, Eric M Girardi, Rufina Kamaletdinova, Justin Chan, Prithviraj Rajebhosale, Steven T Pittenger, Lorna W Role, David A Talmage, Miao Jing, Yulong Li, Xiao-Bing Gao, Yann S Mineur, Marina R Picciotto
Publikováno v:
eLife, Vol 9 (2020)
The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections. We measured BLA ACh signaling and activity of neurons expressin
Externí odkaz:
https://doaj.org/article/223c36eed54e48cfb39c272f2a9258c7
Autor:
Prithviraj Rajebhosale, Alice Jone, Kory Johnson, Camille Palarpalar, Samara Khan, Rohan Hofland, Lorna W. Role, David A. Talmage
Schizophrenia is a complex genetic neurodevelopmental disorder. Expression quantitative trait loci (eQTLs) form the bulk of the genetic variation contributing to schizophrenia. Currently little is known about how eQTL expression is regulated or how t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d7bf1430e3536743fccd008aa71f8b
https://doi.org/10.1101/2022.08.10.503469
https://doi.org/10.1101/2022.08.10.503469
Autor:
Marina R. Picciotto, Chongbo Zhong, Desai N, Jone A, López Hernández G, Li Jiang, Prithviraj Rajebhosale, Lorna W. Role, Richard B. Crouse, Shaohua Wang, Arty C, Li Y, David A. Talmage, Mala Ananth
SummaryAlthough the engagement of cholinergic signaling in threat memory is well established (Knox, 2016a), our finding that specific cholinergic neurons are requisite partners in a threat memory engram is likely to surprise many. Neurons of the basa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568810a3b9b6a3e868d581908e540df8
https://doi.org/10.1101/2021.05.02.442364
https://doi.org/10.1101/2021.05.02.442364
Autor:
Arie E. Kaufman, David A. Talmage, Mala Ananth, Shreeraj Jadhav, Lorna W. Role, Saeed Boorboor
Publikováno v:
IEEE Transactions on Visualization and Computer Graphics. 25:1018-1028
Wide-field microscopes are commonly used in neurobiology for experimental studies of brain samples. Available visualization tools are limited to electron, two-photon, and confocal microscopy datasets, and current volume rendering techniques do not yi