Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Lorna W Harries"'
Autor:
Merlin Davies, Laura R Bramwell, Nicola Jeffery, Ben Bunce, Ben P Lee, Bridget Knight, Cressida Auckland, Jane AH Masoli, Lorna W Harries
Publikováno v:
International Journal of Infectious Diseases, Vol 116, Iss , Pp 418-425 (2022)
Objectives: This study aimed to evaluate the associations between COVID-19 severity and active viral load, and to characterize the dynamics of active SARS-CoV-2 clearance in a series of archival samples taken from patients in the first wave of COVID-
Externí odkaz:
https://doaj.org/article/a1c28eddda07480ca244348b40cd935e
Autor:
Jennifer Munkley, Ling Li, S R Gokul Krishnan, Gerald Hysenaj, Emma Scott, Caroline Dalgliesh, Htoo Zarni Oo, Teresa Mendes Maia, Kathleen Cheung, Ingrid Ehrmann, Karen E Livermore, Hanna Zielinska, Oliver Thompson, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna W Harries, Mads Daugaard, Simon Cockell, Nuno L Barbosa-Morais, Sebastian Oltean, David J Elliott
Publikováno v:
eLife, Vol 8 (2019)
Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet al
Externí odkaz:
https://doaj.org/article/4a90da626b1545618d58b1a38a177512
Autor:
Luke C Pilling, Janice L Atkins, Michael O Duff, Robin N Beaumont, Samuel E Jones, Jessica Tyrrell, Chia-Ling Kuo, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Anna Murray, Michael N Weedon, Lorna W Harries, George A Kuchel, Luigi Ferrucci, Timothy M Frayling, David Melzer
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185083 (2017)
Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and cancer. We investigated inherited genetic variation associated with RDW in 116,666 UK Biob
Externí odkaz:
https://doaj.org/article/04a4afe477254fa0ac97b5879cde81ff
Autor:
Lorna W Harries, Laura J McCulloch, Janet E Holley, Thomas J Rawling, Hannah J Welters, Katarina Kos
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68253 (2013)
Aims/hypothesisWe have previously shown the implication of the multifunctional protein SPARC (Secreted protein acidic and rich in cysteine)/osteonectin in insulin resistance but potential effects on beta-cell function have not been assessed. We there
Externí odkaz:
https://doaj.org/article/120dab7d1f0b4acba4c15e4675fe6096
Autor:
Intza Garin, Guiomar Perez de Nanclares, Elena Gastaldo, Lorna W Harries, Oscar Rubio-Cabezas, Luis Castaño
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29205 (2012)
The aim of this study was to characterize the genetic etiology in a patient who presented with permanent neonatal diabetes at 2 months of age.Regulatory elements and coding exons 2 and 3 of the INS gene were amplified and sequenced from genomic and c
Externí odkaz:
https://doaj.org/article/a0360a5e7d2d43d1b669e1dc94f432e9
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7855 (2009)
BACKGROUND:The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in
Externí odkaz:
https://doaj.org/article/cf8ee69de7f6417e944d37aa6b95a2b9
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7169 (2009)
BackgroundMicroRNAs (miRNAs) are short, noncoding RNAs that regulate the expression of multiple target genes. Deregulation of miRNAs is common in human tumorigenesis. The miRNAs, MIR-15a/16-1, at chromosome band 13q14 are down-regulated in the majori
Externí odkaz:
https://doaj.org/article/c83ca5205432473e816dd3e33701aa01
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-24 (2023)
Abstract Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a hallmark of cancer that profoundly influences the development and progression of prostate cancer (PCa), a prevalent and potentially life-limiting
Externí odkaz:
https://doaj.org/article/a018ef0f11b7414cb1688e0006461cf1
Publikováno v:
Cells, Vol 13, Iss 6, p 517 (2024)
Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecule
Externí odkaz:
https://doaj.org/article/628850f167d143118862f658d814e528
Publikováno v:
Experimental Gerontology, Vol 174, Iss , Pp 112127- (2023)
Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sou
Externí odkaz:
https://doaj.org/article/3fbaf0b0ec904a9894f2220534270df1