Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Lorna Rodriguez"'
Autor:
Nicole Lugo Santiago, Philip H.G. Ituarte, Adrian Kohut, Rosemary Senguttuvan, Nora Ruel, Rebecca Nelson, Ana Tergas, Lorna Rodriguez, Mihae Song
Publikováno v:
Gynecologic Oncology Reports, Vol 54, Iss , Pp 101430- (2024)
Objective: Living in a food desert is a known negative health risk, with recent literature finding an associated higher mortality in patients with cancers. Gynecologic cancers have not specifically been studied. We aimed to describe patients with gyn
Externí odkaz:
https://doaj.org/article/0a79a1561bb6461cb776f075391005fa
Autor:
Lorna Rodriguez-Rodriguez, Rui Huang, Mihaela Cristea, Qianqian Zhao, Adrian Kohut, Hua Yu, Mihae Song, Antons Martincuks, Chunyan Zhang, Edward W Wang, Theresa Austria, Yi-Jia Li, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Binghui Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Ovarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential of poly(ADP-ribose) polymerase inhibitors in treating DNA damage response (DDR)-deficient
Externí odkaz:
https://doaj.org/article/29ce33204b0e45249cb86e478b123daa
Autor:
Eric Hee Jun Lee, John P. Murad, Lea Christian, Jackson Gibson, Yukiko Yamaguchi, Cody Cullen, Diana Gumber, Anthony K. Park, Cari Young, Isabel Monroy, Jason Yang, Lawrence A. Stern, Lauren N. Adkins, Gaurav Dhapola, Brenna Gittins, Wen-Chung Chang, Catalina Martinez, Yanghee Woo, Mihaela Cristea, Lorna Rodriguez-Rodriguez, Jun Ishihara, John K. Lee, Stephen J. Forman, Leo D. Wang, Saul J. Priceman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrai
Externí odkaz:
https://doaj.org/article/211ce127e82c40c7b1c8f149a15dcd09
Autor:
Christina H. Wei, Edward Wang, Evita Sadimin, Lorna Rodriguez-Rodriguez, Mark Agulnik, Janet Yoon, Janine LoBello, Szabolcs Szelinger, Clarke Anderson
Publikováno v:
Gynecologic Oncology Reports, Vol 50, Iss , Pp 101294- (2023)
Externí odkaz:
https://doaj.org/article/d87174b9f16a4304bc0bd2d48e0addbb
Autor:
Christina H Wei, Susan Shehayeb, Nicole Lugo Santiago, Laura Kruper, Ernest Han, Edward Wang, Mihaela Cristea, Lorna Rodriguez-Rodriguez, Susan E Yost, Daphne Stewart
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286998 (2023)
Histologic and genetic mutation information from racially and ethnically diverse populations is warranted to better inform future cancer predisposition and promote health equity. A single institutional, retrospective capture of patients with gynecolo
Externí odkaz:
https://doaj.org/article/0ddad5e697aa4134a687fd18945408e2
Autor:
Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Yu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Recently, poly(ADP-ribosyl)ation polymerase inhibitors (PARPis), which induce synthetic lethality of tumor cells with DNA damage repair defects, have emerged as a promising therapy for ovarian, breast, and pancreatic cancer. Although the PARPi Olapar
Externí odkaz:
https://doaj.org/article/39c14fa5669444e889ed0d1e0d5c327b
Autor:
Elan Gorshein, Kant Matsuda, Gregory Riedlinger, Levi Sokol, Lorna Rodriguez-Rodriguez, Firas Eladoumikdachi, Miral Grandhi, Shridar Ganesan, Deborah L. Toppmeyer, Lindsay Potdevin, Kathleen Toomey, Kim M. Hirshfield, Nancy Chan
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 2, Pp 931-937 (2021)
Metaplastic breast cancer (MBC) is a rare and aggressive subtype of breast cancer. Tumor characteristics typically feature estrogen receptor, progesterone receptor, and HER2-negative, triple-negative breast cancer (TNBC), with a poorer prognosis rela
Externí odkaz:
https://doaj.org/article/bdb6ea84938e4385b44989b9ca95f57f
Autor:
Antons Martincuks, Jieun Song, Adrian Kohut, Chunyan Zhang, Yi-Jia Li, Qianqian Zhao, Edward Mak, Lorna Rodriguez-Rodriguez, Hua Yu, Mihaela Cristea
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Despite the promising activity of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) in many cancer types with defects in the DNA damage response the majority of the treated patients acquire PARPi resistance and succumb to their diseases. Conseque
Externí odkaz:
https://doaj.org/article/5021de688e324a6394b97709ac61908c
Autor:
Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human tri
Externí odkaz:
https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557
Autor:
Bhavna S. Paratala, Jon H. Chung, Casey B. Williams, Bahar Yilmazel, Whitney Petrosky, Kirstin Williams, Alexa B. Schrock, Laurie M. Gay, Ellen Lee, Sonia C. Dolfi, Kien Pham, Stephanie Lin, Ming Yao, Atul Kulkarni, Frances DiClemente, Chen Liu, Lorna Rodriguez-Rodriguez, Shridar Ganesan, Jeffrey S. Ross, Siraj M. Ali, Brian Leyland-Jones, Kim M. Hirshfield
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and sh
Externí odkaz:
https://doaj.org/article/af4ef9c2d18542d6986221a4da000c4e