Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Lorna MacLean"'
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Autor:
Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTVisceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. New therapeutic options with diverse mechanisms of actions (MoAs) are required to consolidate progress toward control o
Externí odkaz:
https://doaj.org/article/7bb16e5a50ee43d6b0b2d50b417e7077
Autor:
Ian H. Gilbert, Sandra Carvalho, Stephen Thompson, Lorna MacLean, Fabio Zuccotto, Susan Wyllie, Timothy J. Miles, Lalitha Sastry, Ignacio Cotillo, Manu De Rycker, Juan A. Bueren-Calabuig, Sonia Moniz, Rachel Milne, Albane Kessler, Maria L. Marco, Julio Martin, Richard J. Wall, Alan H. Fairlamb, Juan Cantizani-Perez, Michael G. Thomas, Stephen Patterson, Sujatha Manthri
Publikováno v:
ACS Infectious Diseases
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbdbdb72ed0d785ae1f89aec7a44bf2
http://europepmc.org/articles/PMC7076694
http://europepmc.org/articles/PMC7076694
Autor:
Kevin D. Read, Sabrinia D. Crouch, Juan Miguel-Siles, Stephen Thompson, Lorna MacLean, Timothy J. Miles, Franck Martin, Alain Claude-Marie Daugan, Suzanne Norval, Laste Stojanovski, Gloria Fra, John Thomas, Frederick R. C. Simeons, Sujatha Manthri, Jose M. Fiandor, César Guerrero, Myriam Ajakane, Maria Osuna-Cabello, Paul G. Wyatt, Manu De Rycker, Lorna Campbell, Claire J. MacKenzie, Ian H. Gilbert, Jennifer Riley, Yoko Shishikura, Michael G. Thomas, Raul F. Velasco
Publikováno v:
RSC Medicinal Chemistry. 11:1168-1177
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907889087930243eaf8e578bd0ada172
https://doi.org/10.1039/d0md00203h
https://doi.org/10.1039/d0md00203h
Autor:
Stephen Patterson, Marta Lopes Lima, Lorna MacLean, Susan Wyllie, David Horn, Lindsay B. Tulloch, Sonia Moniz, Ian H. Gilbert, Richard J. Wall, Victoriano Corpas-López, Fabio Zuccotto, Rachel Milne, Eva Rico, Carmine Marco Morgillo, Leah S. Torrie, Sandra Carvalho
Publikováno v:
Antimicrobial Agents and Chemotherapy
Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas’ disease. Comprehensive mode of action studies revealed that this compound primarily targets the T. cruzi proteasome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f49c0c376d173d0316cb726b4e7b804
https://pubmed.ncbi.nlm.nih.gov/34606338
https://pubmed.ncbi.nlm.nih.gov/34606338
Autor:
Craig W Duffy, Lorna MacLean, Lindsay Sweeney, Anneli Cooper, C Michael R Turner, Andy Tait, Jeremy Sternberg, Liam J Morrison, Annette MacLeod
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2526 (2013)
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development. Trypanosoma brucei rhodesiense, which infec
Externí odkaz:
https://doaj.org/article/0acaed4cd4b840fbbd35bbe014f9daa1
Autor:
Lorna MacLean, Rod J. Dillon, Ali Floyd, Sujatha Manthri, Sarah Cook, Nina Svensen, David Horn, Lalitha Shastry, Holly Yeoman, Michael A. J. Ferguson, Alan R. Prescott, Christy Paterson, Alan H. Fairlamb, Lesley Pearson, Jen Southern, John Thomas, Kevin D. Read
What does lifespan mean for a parasite that reproduces as asexual clones and is revived after 30 years suspended in a deep frozen state? How far does the digital footprint of a parasite stretch online? This work centers on the deadly Leishmania paras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22289aa4ef7b74e3bdc873e438349fab
https://doi.org/10.20933/100001171
https://doi.org/10.20933/100001171
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 10, p e1857 (2012)
Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage. In experimental infections disease progression is associated with neuroinflammatory responses and neurological
Externí odkaz:
https://doaj.org/article/a5c2b599cb1940caa9d7916b3e435541
Autor:
Laste Stojanovski, Tania Bakshi, Iain H. Reid, Maria L. Marco, Stephen Brand, Lars Henrik Sandberg, Sabrinia D. Crouch, Ian H. Gilbert, Lorna MacLean, Jennifer Riley, Christopher J. Nixon, Sharon Robinson, John M. Kelly, Yoko Shishikura, Stephen Thompson, Eun Jung Ko, Kevin D. Read, Daniel Spinks, Jose M. Fiandor, John Thomas, Alan P. Hill, Amanda F. Francisco, Ola Epemolu, Victoria Smith, Chimed Jansen, Paul G. Wyatt, Elisabet Viayna, Sean J. Hindley, Timothy J. Miles, Shiromani Jayawardhana, Frederick R. C. Simeons, Michael G. Thomas, Manu De Rycker, Tim Underwood, Paul Scullion, Maria Osuna-Cabello
Publikováno v:
Journal of Medicinal Chemistry
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent need for new safer treatments because current standard therapeutic options
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8f828f15d0a52e1f719409da74fd5b
http://europepmc.org/articles/PMC5601362
http://europepmc.org/articles/PMC5601362
Autor:
Leah S, Torrie, Stephen, Brand, David A, Robinson, Eun Jung, Ko, Laste, Stojanovski, Frederick R C, Simeons, Susan, Wyllie, John, Thomas, Lucy, Ellis, Maria, Osuna-Cabello, Ola, Epemolu, Andrea, Nühs, Jennifer, Riley, Lorna, MacLean, Sujatha, Manthri, Kevin D, Read, Ian H, Gilbert, Alan H, Fairlamb, Manu, De Rycker
Publikováno v:
ACS Infectious Diseases
Methionyl-tRNA synthetase (MetRS) has been chemically validated as a drug target in the kinetoplastid parasite Trypanosoma brucei. In the present study, we investigate the validity of this target in the related trypanosomatid Leishmania donovani. Fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8857ac374ff4cc86c9c9d657faf2cfba
https://pubmed.ncbi.nlm.nih.gov/28967262
https://pubmed.ncbi.nlm.nih.gov/28967262