Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Lorna M Williamson"'
Autor:
Kathryn L Armour, Cheryl S Smith, Natasha C Y Ip, Cara J Ellison, Christopher M Kirton, Anthony M Wilkes, Lorna M Williamson, Michael R Clark
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109463 (2014)
We previously produced a recombinant version of the human anti-RhD antibody Fog-1 in the rat myeloma cell line, YB2/0. When human, autologous RhD-positive red blood cells (RBC) were sensitised with this IgG1 antibody and re-injected, they were cleare
Externí odkaz:
https://doaj.org/article/65f3f55db7ce499587c95c29912eb449
Autor:
Lorna M. Williamson, Charlene Porter, Gestur Vidarsson, S. Armstrong-Fisher, Nigel M. Stapleton, Kenneth Robert Page, Kathryn L. Armour, C. Ellen van der Schoot, Mike Clark, Donald Wilson Falconer, Masja de Haas, Jan Terje Andersen
Publikováno v:
Molecular immunology, 95, 1-9. Elsevier Limited
We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI–III) and C1q, thereby eliminating their destructive effector functions (constant region G1Δnab). In their potential
Autor:
Mariëlle J P Maas, C. Ellen van der Schoot, Maximilian Brinkhaus, Gestur Vidarsson, Wim J E van Esch, Juk Yee Mok, Arthur E. H. Bentlage, Steven W. de Taeye, A. Robin Temming, Lorna M. Williamson, Giso Brasser, Kathryn L. Armour, Mike Clark, Nigel M. Stapleton
Publikováno v:
Scientific reports, 9(1):7363. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c490c504a73253465b55c5839610f
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
Autor:
A. L. Johnson, Charlotte Llewelyn, A. W. Wells, S. L. Morley, Lorna M. Williamson, C. L. Hudson
Publikováno v:
Transfusion Medicine. 26:111-117
SUMMARYObjective To describe the epidemiology of blood transfusion in children: including the incidence of transfusion, the diagnoses leading to transfusion, donor exposure (DE) and post-transfusion survival. Study design and methods The Epidemiology
Autor:
Kate Pendry, Simon J. Stanworth, Sheila MacLennan, Lorna M. Williamson, Lekha Bakrania, Charlotte Llewelyn, Edwin Massey, Louise Choo, Kay Harding
Publikováno v:
Transfusion. 55:1856-1865
BACKGROUND: Bacterial screening offers the possibility of extending platelet (PLT) storage to Day 7. We conducted a noninferiority, crossover trial comparing PLTs stored for 6 or 7 days versus 2 to 5 days. STUDY DESIGN AND METHODS: Stable hematology
Autor:
Charlotte Llewelyn, Alison Deary, Theodora Foukaneli, Brennan C Kahan, Nina Herbert, Stephen F. Garner, Lorna M. Williamson, Thomas R. Godec, Rebecca Cardigan, Lekha Bakrania, Willem H. Ouwehand, Anne M. Kelly
Publikováno v:
Blood. 130(2)
The effect of variation in platelet function in platelet donors on patient outcome following platelet transfusion is unknown. This trial assessed the hypothesis that platelets collected from donors with highly responsive platelets to agonists in vitr
Publikováno v:
Neonatology. 107:1-7
Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count 9/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn
Autor:
Louise Choo, Melanie Kirby-Allen, Sally C. Davies, Lorna M. Williamson, Renate Hodge, David C. Rees, Karin Fijnvandraat, Moira Malfroy, Mark Sculpher, Charlotte Llewelyn, Jo Howard, Eldon Spackman, Tony Johnson
Publikováno v:
European journal of haematology, 92(3), 249-255. Wiley-Blackwell
European Journal of Haematology
European Journal of Haematology
The study’s objective was to assess the cost-effectiveness of preoperative transfusion compared with no preoperative transfusion in patients with sickle cell disease undergoing low- or medium-risk surgery. Seventy patients with sickle cell disease
Autor:
Mike Clark, Kottekkattu Balan, Louise Hawkins, Amanda C. Evans, Kathryn L. Armour, Nicola Grehan, Lorna M. Williamson, Stephen F. Garner, Cedric Ghevaert, Paul Lloyd-Evans, Nina Herbert, Abigail Crisp-Hihn, Philip Cookson, Willem H. Ouwehand
Publikováno v:
Blood. 122:313-320
Fetomaternal alloimmune thrombocytopenia, caused by the maternal generation of antibodies against fetal human platelet antigen-1a (HPA-1a), can result in intracranial hemorrhage and intrauterine death. We have developed a therapeutic human recombinan
Autor:
Moira Malfroy, Eldon Spackman, Tony Johnson, Sally C. Davies, Louise Tillyer, Jo Howard, Isabeau Walker, Melanie Kirby-Allen, Shilpi Purohit, Karin Fijnvandraat, Louise Choo, David C. Rees, Lorna M. Williamson, Charlotte Llewelyn, Renate Hodge
Publikováno v:
Lancet, 381(9870), 930-938. Elsevier Limited
Summary Background No consensus exists on whether preoperative blood transfusions are beneficial in patients with sickle-cell disease. We assessed whether perioperative complication rates would be altered by preoperative transfusion. Methods We did a