Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lorna Layward"'
Autor:
Anne Rigby, Sandrine Vessillier, David Baker, Gill Adams, Lorna Layward, Lisa Mullen, Alex Annenkov, Gayatri Mittal, Michelle Sclanders, Yuti Chernajovsky, David Gould
Publikováno v:
Expert Opinion on Drug Delivery. 11:101-110
The use of cytokines as therapeutic agents is important, given their potent biological effects. However, this very potency, coupled with the pleiotropic nature and short half-life of these molecules, has limited their therapeutic use. Strategies to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251ef38779a7c12968db94b9c7ab01ae
https://doi.org/10.1517/17425247.2014.863872
https://doi.org/10.1517/17425247.2014.863872
Autor:
Gill Adams, Mario Köster, Sandrine Vessillier, Hansjörg Hauser, Julie Foster, Lorna Layward, Yuti Chernajovsky, David Gould, Lisa Mullen
Publikováno v:
Annals of the Rheumatic Diseases. 73:1728-1736
Background Latent cytokines are engineered by fusing the latency associated peptide (LAP) derived from transforming growth factor-β (TGF-β) with the therapeutic cytokine, in this case interferon-β (IFN-β), via an inflammation-specific matrix meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b5a6bbb8b4cb0114594dce4cdec153
https://doi.org/10.1136/annrheumdis-2013-203513
https://doi.org/10.1136/annrheumdis-2013-203513
Autor:
Lorna Layward, Pamela Holmes
Publikováno v:
British Journal of Community Nursing. 11:433-436
In this article, brought to you in association with Help the Aged, the authors discuss current research into the causes and management of urinary incontinence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ed436726e17055f7c98a9e2baded3b
https://doi.org/10.12968/bjcn.2006.11.10.21965
https://doi.org/10.12968/bjcn.2006.11.10.21965
Publikováno v:
Clinical and Experimental Immunology. 122:445-452
SUMMARYPolyunsaturated fatty acids are known to affect the immune response and administration of the omega-6 fatty acid linoleic acid has been reported to be beneficial in multiple sclerosis (MS) and EAE. In this study we have investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf96042bb1fa6a87565db9fb713aff33
https://doi.org/10.1046/j.1365-2249.2000.01399.x
https://doi.org/10.1046/j.1365-2249.2000.01399.x
Publikováno v:
Immunology Today. 18:368-371
Correlation of the heterogeneic immunopathological profiles of multiple sclerosis (MS) lesions with the paraclinical and clinical markers of disease may be important in the development of therapeutic approaches in MS. This and other issues were discu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4de8d2f81f268371f7cb334a97beb5
https://doi.org/10.1016/s0167-5699(97)01100-6
https://doi.org/10.1016/s0167-5699(97)01100-6
Autor:
Gayatri Mittal, Lorna Layward, Sarah Al-Izki, Rewas Fatah, David Baker, Gill Adams, Alex Annenkov, Sandrine Vessillier, Chris Bolton, Yuti Chernajovsky, Julie Foster, Anne Rigby, Gareth Pryce, Hansjörg Hauser, Cristina Subang, Lisa Mullen, David Gould, Julia M Colston, Michelle Sclanders, Philippa Francis-West, Mario Köster
Publikováno v:
Expert opinion on drug delivery. 11(1)
Targeting cytokines to sites of disease has clear advantages because it increases their therapeutic index. We designed fusion proteins of the latent-associated peptide (LAP) derived from TGF-β with various cytokines via a matrix metalloproteinase (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6129e5be2be84478d176a51bc100d62f
https://pubmed.ncbi.nlm.nih.gov/24073618
https://pubmed.ncbi.nlm.nih.gov/24073618
Publikováno v:
Amor, S, Layward, L & Van Noort, J M 1998, ' Multiple sclerosis : Modelling the future ', Molecular Medicine Today, vol. 4, no. 8, pp. 328-330 . https://doi.org/10.1016/S1357-4310(98)01305-7
Molecular Medicine Today, 4(8), 328-330. Elsevier BV
Molecular Medicine Today, 4(8), 328-330. Elsevier BV
The Multiple Sclerosis Society of Great Britain and Northern Ireland Conference: Frontiers in Science and Patient Care Disease Management Birmingham, UK, 5–6 May 1998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ba8346e2d543ad0893a444b722c83a
https://doi.org/10.1016/s1357-4310(98)01305-7
https://doi.org/10.1016/s1357-4310(98)01305-7
Publikováno v:
BMJ (Clinical research ed.). 332(7534)
Although gene therapy has huge potential for modern medicine, our enthusiasm for its powerful potential must not cloud our judgment about the dangers of using increasingly diverse, yet relatively untested, replicating viruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbe34f84aa9c18dff2c7e1cb80d99b8
https://pubmed.ncbi.nlm.nih.gov/16424499
https://pubmed.ncbi.nlm.nih.gov/16424499
Autor:
Lorna Layward
Publikováno v:
Current biology : CB. 8(2)
There has been a quiet revolution in UK medical charities over the past two decades. Increasing competition for donations, adoption of new roles relative to the state and private sectors, and the requirement for more accountability have all played th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdc1373102fba7af17460ca96607f40
https://pubmed.ncbi.nlm.nih.gov/9427653
https://pubmed.ncbi.nlm.nih.gov/9427653
Publikováno v:
Biochemical Society transactions. 25(2)
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune and demyelinating disease of the central nervous system (CNS) inducible in susceptible rodents and other mammalian species by active or adoptive sensitization to CNS constituents [I]. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641fa5c5bab65d16c5ecdf4fb6536775
https://pubmed.ncbi.nlm.nih.gov/9191387
https://pubmed.ncbi.nlm.nih.gov/9191387