Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lorna Kategaya"'
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://doaj.org/article/e0d8a246d19143f9bd877f0b6caa0659
Autor:
William F. Forrest, Sumit Prakash, Vickie Tsui, Adam R. Renslo, Richard Pastor, Christiaan Klijn, Frank Peale, Mark McCleland, Lorna Kategaya, Carsten Schwerdtfeger, Zachary Stiffler, Matthias Trost, Frederick Cohen, Priyadarshini Jaishankar, Kevin R Clark, Paola Di Lello, Bradley B. Brasher, Florian Gnad, Michael C. M. Kwok, Johanna Heideker, Jeremy Murray, Jason Drummond, Xiaojing Wang, Maria Stella Ritorto, Till Maurer, Maureen Beresini, Matthew T. Chang, James A. Ernst, Taylur P. Ma, Robert A. Blake, Elizabeth Blackwood, Dario R. Alessi, Michelle R. Arkin, Lionel Rouge, Kebing Yu, Brian R. Hearn, Travis W. Bainbridge, Eva Lin, Tracy Kleinheinz, Yinyan Tang, Chudi Ndubaku, Scott E. Martin, John-Paul Upton, Ingrid E. Wertz
Publikováno v:
Nature. 550:534-538
The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7. Deubiquitinating
Autor:
Kyoung Jin Lee, Alfonso Arrazate, Carlos L. Arteaga, Robert A. Blake, Peter J. Rix, Nhin Lu, Steven P. Govek, Mohammed N. Tantawy, Jeffrey H. Hager, Eric D. Bischoff, Jim Nonomiya, Kimberly Walter, Andiliy G. Lai, Kate Grillot, Richard A. Heyman, Ellen Ingalla, Rene Prudente, Lorna Kategaya, Luis J. Schwarz, Gang Shao, Wei Zhou, Benjamin Haley, Ciara Metcalfe, Deepak Sampath, Jennifer M. Giltnane, Dan Brigham, James Joseph, Josh Kaufman, Mark R. Lackner, Beatrice Darimont, Michelle Nannini, Amy E. Young, John Sensintaffar, Karensa L. Douglas, Julien Jackaline D, Zhengyu Guan, Ingrid E. Wertz, Michael Moon, Anna Aparicio, Nicholas D. Smith, Celine Bonnefous, Johnny Y. Nagasawa, Henry C. Manning, Mehmet Kahraman, Jing Qian, Lori Friedman
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Autor:
Ellen Ingalla, Amy Young, LS Friedman, Vidhi Mody, Jane Guan, Xuehai Wang, Savita Ubhayakar, Jun Liang, Jae H. Chang, Ingrid E. Wertz, Jason R. Zbieg, Marc Hafner, Tracy Kleinheinz, Wei Zhou, Deepak Sampath, Michelle Nannini, Anneleen Daemen, Jennifer M. Giltnane, Jason Oeh, Lorna Kategaya, Steven J. Hartman, T De Bruyn, Robert A. Blake, Ciara Metcalfe
Publikováno v:
Cancer Research. 79:P5-04
ER+ breast cancers depend on ER signaling throughout disease progression, including after acquired resistance to existing endocrine agents, providing a rationale for further optimization and development of ER-targeting agents. Fulvestrant is unique a
Autor:
Gang Shao, Dan Brigham, Henry C. Manning, Mohammed N. Tantawy, Michael Moon, Zhengyu Guan, Amy Young, Ingrid E. Wertz, Anna Aparicio, Carlos L. Arteaga, Lori Friedman, Kyoung Jin Lee, Luis J. Schwarz, Jennifer M. Giltnane, Mehmet Kahraman, Robert A. Blake, Wei Zhou, Alfonso Arrazate, Eric D. Bischoff, Benjamin Haley, Josh Kaufman, Jim Nonomiya, Deepak Sampath, Peter J. Rix, Kate Grillot, Lorna Kategaya, Ellen Ingalla, John Sensintaffar, Ciara Metcalfe, Celine Bonnefous, Johnny Y. Nagasawa, Richard A. Heyman, Beatrice Darimont, Michelle Nannini, Steven P. Govek, Jeffrey H. Hager, Kimberly Walter, Nhin Lu, Rene Prudente, Mark R. Lackner, Karensa L. Douglas, Julien Jackaline D, Nicholas D. Smith, Andiliy G. Lai, Jing Qian, James Joseph
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efacfb3ed19a9aba3fed3faccefbccfc
https://doi.org/10.7554/elife.15828.026
https://doi.org/10.7554/elife.15828.026
Autor:
Robert J. Newman, Mercedesz Balazs, Kebing Yu, Jinfeng Liu, Keisuke Horikawa, Wendy Sandoval, Wyne P. Lee, Kim Newton, Flavius Martin, Michael J. Townsend, Nandhini Ramamoorthi, Lorna Kategaya, Jeffrey Tom, Erin C. Dueber, Wayne J. Fairbrother, Christopher C. Goodnow, Allyn J. Schoeffler, Saritha Kusam, Anuradha Zindal, Vishva M. Dixit, Clifford Quan, Ganesh Kolumam, Elizabeth Helgason, Juan Zhang, Debra L. Dugger, Jason DeVoss, Cynthia Lam, Surinder Jeet, Søren Warming, Patrick Caplazi, Dhaya Seshasayee, Susmith Mukund, Ingrid E. Wertz, Nataliya Popovych
Publikováno v:
Nature. 528(7582)
Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's disease. However, the role of A20 in attenuating inflammatory signalling is u
Autor:
Maureen Beresini, Matthew T. Chang, Brian R. Hearn, Bradley B. Brasher, Mark McCleland, Ingrid E. Wertz, Lionel Rouge, Tracy Kleinheinz, Kebing Yu, Yinyan Tang, Richard Pastor, Jason Drummond, Chudi Ndubaku, James A. Ernst, William F. Forrest, Scott E. Martin, Christiaan Klijn, Frederick Cohen, John-Paul Upton, Taylur P. Ma, Dario R. Alessi, Carsten Schwerdtfeger, Paola Di Lello, Robert A. Blake, Eva Lin, Travis W. Bainbridge, Sumit Prakash, Adam R. Renslo, Vickie Tsui, Zachary Stiffler, Frank Peale, Maria Stella Ritorto, Till Maurer, Florian Gnad, Jeremy Murray, Matthias Trost, Elizabeth Blackwood, Michael C. Kwok, Priya Jaishanker, Xiaojing Wang, Lorna Kategaya, Kevin R Clark, Johanna Heideker, Michelle R. Arkin
Publikováno v:
Cancer Research. 78:SY23-03
The ubiquitin system regulates the majority of cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains, and the topology of ubiquitin modifications regulates substrate interactions with specific proteins. Th
Autor:
Vickie Tsui, Paola Di Lello, James A. Ernst, Andy D. Tran, Yi Cao, Richard Pastor, Michael C. M. Kwok, Jeremy Murray, Ben Haley, Mark McCleland, Beth Blackwood, Trinna L. Cuellar, Jinfeng Liu, Till Maurer, David Stokoe, Chudi Ndubaku, Cuong Ly, Ingrid E. Wertz, Jake Drummond, Robert A. Blake, Sharon Yee, Lorna Kategaya, Joy Drobnick
Publikováno v:
Clinical Cancer Research. 23:B23-B23
Deubiquitinases (DUBs) are enzymes that proteolytically cleave ubiquitin from substrates. Substrates include oncogenes, tumor suppressors and polyubiquitinated proteins marked for degradation by the proteasome. Ubiquitin specific peptidase-7 (USP7) d