Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lorna J, Chebon"'
Autor:
Ben Andagalu, Pinyi Lu, Irene Onyango, Elke Bergmann-Leitner, Ruth Wasuna, Geoffrey Odhiambo, Lorna J. Chebon-Bore, Luicer A. Ingasia, Dennis W. Juma, Benjamin Opot, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Raphael Okoth, Gladys Chemwor, Joseph Campo, Anders Wallqvist, Hoseah M. Akala, Daniel Ochiel, Bernhards Ogutu, Sidhartha Chaudhury, Edwin Kamau
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether
Externí odkaz:
https://doaj.org/article/8860f475c2f14a1a9ac4fc3bf97ccf77
Autor:
Peninah Muiruri, Denis W. Juma, Luicer A. Ingasia, Lorna J. Chebon, Benjamin Opot, Bidii S. Ngalah, Jelagat Cheruiyot, Ben Andagalu, Hoseah M. Akala, Venny C. S. Nyambati, Joseph K. Ng’ang’a, Edwin Kamau
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorp
Externí odkaz:
https://doaj.org/article/5d8aeccd66544f9b84e14a2a193839fb
Autor:
Lorna J Chebon, Bidii S Ngalah, Luicer A Ingasia, Dennis W Juma, Peninah Muiruri, Jelagat Cheruiyot, Benjamin Opot, Emmanuel Mbuba, Mabel Imbuga, Hoseah M Akala, Wallace Bulimo, Ben Andagalu, Edwin Kamau
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162524 (2016)
Genetically determined artemisinin resistance in Plasmodium falciparum has been described in Southeast Asia. The relevance of recently described Kelch 13-propeller mutations for artemisinin resistance in Sub-Saharan Africa parasites is still unknown.
Externí odkaz:
https://doaj.org/article/56009bc8fab346629c57fb18b64960bd
Autor:
Redemptah Yeda, Luicer A Ingasia, Agnes C Cheruiyot, Charles Okudo, Lorna J Chebon, Jelagat Cheruiyot, Hoseah M Akala, Edwin Kamau
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0143565 (2016)
The Plasmodium falciparum in vitro culture system is critical for genotypic and phenotypic analyses of the parasites. For genotypic analysis, the genomic DNA can be obtained directly from the patient blood sample or from culture adapted parasites whe
Externí odkaz:
https://doaj.org/article/bd321eb9334a4710bc2d246b8bec2f2f
Autor:
Agnes C. Cheruiyot, Ruth Wasuna, Elke S. Bergmann-Leitner, Pinyi Lu, Luicer A. Ingasia, Sidhartha Chaudhury, Edwin Kamau, Redemptah Yeda, Daniel Ochiel, Geoffrey Odhiambo, Charles Okudo, Joseph J. Campo, Ben Andagalu, Hoseah M. Akala, Anders Wallqvist, Dennis W. Juma, Gladys C. Chemwor, Irene Onyango, Raphael Okoth, Benjamin Opot, Lorna J. Chebon-Bore, Bernhards Ogutu
The role of humoral immunity on the efficacy of artemisinin combination therapy (ACT) has not been investigated, yet naturally acquired immunity is key determinant of antimalarial therapeutic response. We conducted a therapeutic efficacy study in hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887a368c9aaba7d2252a1e7af726cca3
https://doi.org/10.1101/2020.08.12.248724
https://doi.org/10.1101/2020.08.12.248724
Autor:
Luicer A. Ingasia, Zaydah R. de Laurent, Edwin Kamau, Hoseah M. Akala, Ben Andagalu, Lynette Isabella Ochola-Oyier, Lorna J. Chebon
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 98:1360-1366
The development of artemisinin (ART)-resistant parasites in Southeast Asia (SEA) threatens malaria control globally. Mutations in the Kelch 13 (K13)-propeller domain have been useful in identifying ART resistance in SEA. ART combination therapy (ACT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeb91ef8e7c7b59d37f95e78a60b5d04
https://doi.org/10.4269/ajtmh.17-0505
https://doi.org/10.4269/ajtmh.17-0505
Autor:
Benjamin Opot, Denis W. Juma, Peninah Muiruri, Luicer A. Ingasia, Jelagat Cheruiyot, Lorna J. Chebon, Joseph K. Ng’ang’a, Hoseah M. Akala, Edwin Kamau, Venny C. S. Nyambati, Bidii S. Ngalah, Ben Andagalu
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Malaria Journal
Malaria Journal
Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01560b976ba05dec7908b2c014459e3f
https://doi.org/10.1186/s12936-018-2534-8
https://doi.org/10.1186/s12936-018-2534-8
Autor:
Zaydah R, de Laurent, Lorna J, Chebon, Luicer A, Ingasia, Hoseah M, Akala, Ben, Andagalu, Lynette Isabella, Ochola-Oyier, Edwin, Kamau
Publikováno v:
The American journal of tropical medicine and hygiene. 98(5)
The development of artemisinin (ART)-resistant parasites in Southeast Asia (SEA) threatens malaria control globally. Mutations in the Kelch 13 (K13)-propeller domain have been useful in identifying ART resistance in SEA. ART combination therapy (ACT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b8ce7a1dfc91bd33b79fff1128b6aca
https://pubmed.ncbi.nlm.nih.gov/29582728
https://pubmed.ncbi.nlm.nih.gov/29582728
Autor:
Apollo Asenath, K. Mitei, Hoseah M. Akala, Lorna J. Chebon, Andrew Nyerere, Dennis W. Juma, Matthew L. Brown, Benjamin Opot, Ben Andagalu
Publikováno v:
Advanced Techniques in Biology & Medicine.
Background: Microscopic parasite detection during the course of treatment or follow-up suggests that a proportion of ACT treated children in Kenya do not completely clear Plasmodium falciparum parasitemia. Plasmodium falciparum mutation in chloroquin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b927f5a246117760a8bd8a80931ed51
https://doi.org/10.4172/2379-1764.1000259
https://doi.org/10.4172/2379-1764.1000259
Autor:
Fredrick Eyase, Lorna J. Chebon, Jacob D. Johnson, Peninah Muiruri, Ngalah S. Bidii, Benjamin Opot, Wallace D. Bulimo, Redemptah Yeda, Dennis W. Juma, Agnes C. Cheruiyot, Paul Oyieng’ Ang’ienda, Edwin Kamau, Ben Andagalu, Charles Okudo, Jelagat Cheruiyot, Joan Mativo, Luicer A. Ingasia, Angela A. Omondi, Hoseah M. Akala, J.M. Ndegwa
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3737-3743
In combination with antibiotics, quinine is recommended as the second-line treatment for uncomplicated malaria, an alternative first-line treatment for severe malaria, and for treatment of malaria in the first trimester of pregnancy. Quinine has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d7084b8f2bb056a2ac13d233b47243
https://doi.org/10.1128/aac.02472-14
https://doi.org/10.1128/aac.02472-14