Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Lorna Ewart"'
Autor:
Ramin Pajoumshariati, Lorna Ewart, Ville Kujala, Raymond Luc, Samantha Peel, Adam Corrigan, Heather Weber, Bramasta Nugraha, Pernille B. L. Hansen, Julie Williams
Publikováno v:
Advanced Science, Vol 10, Iss 33, Pp n/a-n/a (2023)
Abstract The function of the glomerulus depends on the complex cell–cell/matrix interactions and replication of this in vitro would aid biological understanding in both health and disease. Previous models do not fully reflect all cell types and int
Externí odkaz:
https://doaj.org/article/40d07dfc9c4243bab8676a40760b5937
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
Externí odkaz:
https://doaj.org/article/8af1884ce4df43869295c061cce05605
Autor:
Jonathan Cairns, Emilyanne Leonard, Kainat Khan, Conor Parks, Gareth Maglennon, Bairu Zhang, Stanley E. Lazic, Lorna Ewart, Rhiannon David
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Microphysiological systems (MPS; organ-on-a-chip) aim to recapitulate the 3D organ microenvironment and improve clinical predictivity relative to previous approaches. Though MPS studies provide great promise to explore treatment options
Externí odkaz:
https://doaj.org/article/1257d15b6da04bb7825cb361187ba6d5
Autor:
S. Kerns, Chaitra Belgur, Marianne Kanellias, Dimitris Manatakis, Debora Petropolis, Riccardo Barrile, Will Tien-Street, Lorna Ewart, Nikolche Gjorevski, Lauriane Cabon
Publikováno v:
Bio-Protocol, Vol 13, Iss 1 (2023)
Traditional drug safety assessments often fail to predict complications in humans, especially when the drug targets the immune system. Rodent-based preclinical animal models are often ill-suited for predicting immunotherapy-mediated adverse events in
Externí odkaz:
https://doaj.org/article/28a3a7f198cd424385a78979e76c86d4
Autor:
Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Chris D. Hinojosa, William Tien-Street, Elias S. Manolakos, Kostas Vekrellis, Geraldine A. Hamilton, Lorna Ewart, Lee L. Rubin, Katia Karalis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel th
Externí odkaz:
https://doaj.org/article/4c79c98786c94d82a820ab3e121c9759
Autor:
Hongbing Wang, Paul C. Brown, Edwin C.Y. Chow, Lorna Ewart, Stephen S. Ferguson, Suzanne Fitzpatrick, Benjamin S. Freedman, Grace L. Guo, William Hedrich, Scott Heyward, James Hickman, Nina Isoherranen, Albert P. Li, Qi Liu, Shannon M. Mumenthaler, James Polli, William R. Proctor, Alexandre Ribeiro, Jian‐Ying Wang, Ronald L. Wange, Shiew‐Mei Huang
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1659-1680 (2021)
Abstract Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and si
Externí odkaz:
https://doaj.org/article/523a044f71fe468699fe3793345748a3
Autor:
Tomasz Kostrzewski, Sophie Snow, Anya Lindström Battle, Samantha Peel, Zahida Ahmad, Jayati Basak, Manasa Surakala, Aurelie Bornot, Julia Lindgren, Maria Ryaboshapkina, Maryam Clausen, Daniel Lindén, Christian Maass, Lucy May Young, Adam Corrigan, Lorna Ewart, David Hughes
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the m
Externí odkaz:
https://doaj.org/article/2fe033487d4045ff86e6fb36c7f3e8b7
Autor:
Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Sonalee Barthakur, Alexander Sorets, Achille Gravanis, Lorna Ewart, Lee L. Rubin, Elias S. Manolakos, Christopher D. Hinojosa, Katia Karalis
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104813- (2022)
Summary: Species differences in brain and blood–brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present a human organotypic microphys
Externí odkaz:
https://doaj.org/article/493b7bfb538444d6ae5060c22bb9d2ef
Autor:
Athanasia Apostolou, Rohit A. Panchakshari, Antara Banerjee, Dimitris V. Manatakis, Maria D. Paraskevopoulou, Raymond Luc, Galeb Abu-Ali, Alexandra Dimitriou, Carolina Lucchesi, Gauri Kulkarni, Tengku Ibrahim Maulana, Magdalena Kasendra, Jordan S. Kerns, Bertram Bleck, Lorna Ewart, Elias S. Manolakos, Geraldine A. Hamilton, Cosmas Giallourakis, Katia Karalis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1719-1741 (2021)
Background & Aims: The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to be harnessed for the development of therapeutics as well as
Externí odkaz:
https://doaj.org/article/8581303f9bfe4c679f3e7c038c1061c8
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5e27c6f2cc2e4fe0a5530d0d36badbf6