Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lorna A. Ringwood"'
Autor:
Mark R. Duranski, Peter H. MacArthur, Xunde Wang, Amir Shoja, David J. Lefer, Nalini Raghavachari, Sruti Shiva, Michael N. Sack, Mark T. Gladwin, John W. Calvert, James J. M. Greer, Lorna A. Ringwood, Paul S. Brookes, Lindsay S. Burwell
Publikováno v:
The Journal of Experimental Medicine
Nitrite (NO2−) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the mammalian heart, liver, and brain. Although the mechanism of nitrite-mediated cytoprotection is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc38385a06c8e7db88d1efbcb1c3e071
https://doi.org/10.1084/jem.20070198
https://doi.org/10.1084/jem.20070198
Autor:
Neil Hogg, Ivan Azarov, Daniel B. Kim-Shapiro, Alice Jiang, Mahesh S. Joshi, Rozalina Grubina, Swati Basu, Mark T. Gladwin, Sruti Shiva, Zhi Huang, Lorna A. Ringwood
Publikováno v:
Journal of Biological Chemistry. 282:12916-12927
Recent studies reveal a novel role for hemoglobin as an allosterically regulated nitrite reductase that may mediate nitric oxide (NO)-dependent signaling along the physiological oxygen gradient. Nitrite reacts with deoxyhemoglobin in an allosteric re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5f9d17132019d8373338034301fcb5
https://doi.org/10.1074/jbc.m700546200
https://doi.org/10.1074/jbc.m700546200
Autor:
Rania Hito, Mark T. Gladwin, Christian J. Hunter, Mildred M. Pelletier, Petra Kleinbongard, Alan N. Schechter, Andre Dejam, Lorna A. Ringwood
Publikováno v:
Free Radical Biology and Medicine. 41:541-548
There are a number of difficulties involved in the quantification of nitrite in biological systems. These difficulties result from oxidation of nitrite (within minutes) by heme proteins, such as hemoglobin, myoglobin, cytoglobin, and neuroglobin; its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9cb9e30728834de0ba7f7fe2b64039
https://doi.org/10.1016/j.freeradbiomed.2006.05.001
https://doi.org/10.1016/j.freeradbiomed.2006.05.001
Autor:
Vidhya Annavajjhala, Susan Yuditskaya, Zena Leah Harris, Xunde Wang, Xueying Xu, Sruti Shiva, Hiroaki Miyajima, Lorna A. Ringwood, Mark T. Gladwin, Neil Hogg
Publikováno v:
Nature Chemical Biology. 2:486-493
Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50fcd36cd07f3ccd2e77df837f915f5
https://doi.org/10.1038/nchembio813
https://doi.org/10.1038/nchembio813
Autor:
Pamela S. Vincent, Lorna A. Ringwood, Sruti Shiva, Li-Yueh Hsu, Andrew E. Arai, Mark T. Gladwin, Anthony H. Aletras, Felix M. Gonzalez, Yuen Yi Hon, Richard O. Cannon
Publikováno v:
Circulation. 117(23)
Background— Accumulating evidence suggests that the ubiquitous anion nitrite (NO 2 − ) is a physiological signaling molecule, with roles in intravascular endocrine nitric oxide transport, hypoxic vasodilation, signaling, and cytoprotection. Thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7eb3c3c3c5ffc84ce8b1268c0b0c26
https://pubmed.ncbi.nlm.nih.gov/19451359
https://pubmed.ncbi.nlm.nih.gov/19451359
Autor:
Peter H. MacArthur, Elizabeth Murphy, Junhui Sun, Victor M. Darley-Usmar, Sruti Shiva, Lorna A. Ringwood, Rozalina Grubina, Zhi Huang, Xiuli Xu, Mark T. Gladwin
Publikováno v:
Circulation research. 100(5)
Previous studies have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO) in blood. It has been proposed that nitrite acts as an endocrine reservoir of NO and contributes to hypoxic vasodilation and signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c68c0af66dbd4a97edf089d4f02b280
https://pubmed.ncbi.nlm.nih.gov/17293481
https://pubmed.ncbi.nlm.nih.gov/17293481
Autor:
Zhi Huang, Kris T. Huang, Daniel B. Kim-Shapiro, Alan N. Schechter, Lorna A. Ringwood, Mark T. Gladwin, Rakesh P. Patel, Cynthia E. Irby, Chien Ho, Sruti Shiva, Neil Hogg
Publikováno v:
The Journal of clinical investigation. 115(8)
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80 years ago, the precise identity and mechanism of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faca40f9f53bf2d0757f8803b9bb76a
https://pubmed.ncbi.nlm.nih.gov/16041407
https://pubmed.ncbi.nlm.nih.gov/16041407
Autor:
Mark R. Duranski, David J. Lefer, Laur Kirby, Sruti Shiva, Mark T. Gladwin, Michael N. Sack, Lorna A. Ringwood
Publikováno v:
Nitric Oxide. 14:73-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e0dafa07614eba3d17b335a5154488
https://doi.org/10.1016/j.niox.2006.04.242
https://doi.org/10.1016/j.niox.2006.04.242
Publikováno v:
Blood. 108:1561-1561
Previous studies have demonstrated that nitrite is an endocrine store of NO that may play an important role in hypoxic vasodilation. Nitrite can be converted to NO enzymatically by deoxyhemoglobin, in a reaction that is under allosteric control with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a01fcd44e9b838ec4528df45559746cb
https://doi.org/10.1182/blood.v108.11.1561.1561
https://doi.org/10.1182/blood.v108.11.1561.1561
Publikováno v:
Nitric Oxide. 14:72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b24df2d068ee9e7f7ce587274c58635
https://doi.org/10.1016/j.niox.2006.04.236
https://doi.org/10.1016/j.niox.2006.04.236