Výsledky vyhledávání - "Lorna, Hodgson"

Akademický článek

Acute depletion of diacylglycerol from the cis-Golgi affects localized nuclear envelope morphology during mitosis

Autor: Gary Hong Chun Chung, Marie-Charlotte Domart, Christopher Peddie, Judith Mantell, Kieran Mclaverty, Angela Arabiotorre, Lorna Hodgson, Richard D. Byrne, Paul Verkade, Kenton Arkill, Lucy M. Collinson, Banafshé Larijani

Publikováno v: Journal of Lipid Research, Vol 59, Iss 8, Pp 1402-1413 (2018)

Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated pro

Externí odkaz: https://doaj.org/article/4427097e29ec42fd9b6672ab3da01cf7

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Self-assembly of nanofilaments in cyanobacteria for protein co-localization

Autor: Julie A. Z. Zedler, Alexandra M. Schirmacher, David A. Russo, Lorna Hodgson, Emil Gundersen, Annemarie Matthes, Stefanie Frank, Paul Verkade, Poul Erik Jensen

Cyanobacteria offer great potential as alternative biotechnological hosts due to their photoautotrophic capacities. However, in comparison to established heterotrophic hosts, several key aspects, such as product titers, are still lagging behind. Nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f49f1eb1dcc394e46544b0240e56a176
https://doi.org/10.1101/2023.02.12.528169

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The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

Publikováno v: Toelzer, C, Gupta, K, Yadav Kadapalakere, S, Hodgson, L R, Kavanagh Williamson, M, Buzas, D, Borucu, U, Powers, K T, Stenner, R A, Vasileiou, K, Garzoni, F, Fitzgerald, D J, Payré, C, Gautam, G, Lambeau, G, Davidson, A D, Verkade, P, Martin, F, Berger, I & Berger-Schaffitzel, C H 2022, ' The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron ', Science Advances, vol. 8, no. 47, eadc9179 . https://doi.org/10.1101/2022.04.22.489083, https://doi.org/10.1126/sciadv.adc9179

As COVID-19 persists, severe acquired respiratory syndrome coronavirus-2 (SARS-CoV-2) Variants of Concern (VOCs) emerge, accumulating spike (S) glycoprotein mutations. S receptor-binding domain (RBD) comprises a free fatty acid (FFA)-binding pocket.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f2b78395682ad7de4416f8224a32da
https://doi.org/10.1126/sciadv.adc9179

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Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers

Autor: Yunxiang He, Ian Manners, Steven T. G. Street, Paul Verkade, Lorna Hodgson, Xu-Hui Jin

Publikováno v: Chemical Science
Street, S T G, He, Y, Jin, X-H, Hodgson, L, Verkade, P & Manners, I 2020, ' Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers ', Chemical Science, vol. 11, no. 32, pp. 8394-8408 . https://doi.org/10.1039/d0sc02593c

Polymer-based nanoparticles show substantial promise in the treatment and diagnosis of cancer and other diseases. Herein we report an exploration of the cellular uptake of tailored, low dispersity segmented 1D nanoparticles which were prepared from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa155cf5a7c1f6928cb363913bd03c7a
https://doi.org/10.1039/d0sc02593c

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ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Autor: Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Phil Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Publikováno v: Proceedings of the National Academy of Sciences (PNAS)
Proceedings of the National Academy of Sciences of the United States of America, 119 (25)
bioRxiv
Simonetti, B, Daly, J, Klein, K, Anton Plagaro, C, Hodgson, L R, Heesom, K J, Shoemark, D K, Davidson, A D, Yamauchi, Y, Cullen, P J & et, A 2022, ' ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 25, 2201980119 . https://doi.org/10.1073/pnas.2201980119

Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed “cargoes”) from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e100d965e9a854a4cdb5dbee6ca5d5

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Refining a correlative light electron microscopy workflow using luminescent metal complexes

Autor: Jonathan R, Shewring, Lorna, Hodgson, Helen L, Bryant, Per A, Bullough, Julia A, Weinstein, Paul, Verkade

Publikováno v: Methods in cell biology. 162

The potential for increasing the application of Correlative Light Electron Microscopy (CLEM) technologies in life science research is hindered by the lack of suitable molecular probes that are emissive, photostable, and scatter electrons well. Most b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8105dad04ac6d0358da7bdb6124a790a
https://pubmed.ncbi.nlm.nih.gov/33707023

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Fluorescent platinum nanoclusters as correlative light electron microscopy probes

Autor: Hugh, Tanner, Lorna, Hodgson, Judith, Mantell, Paul, Verkade

Publikováno v: Methods in cell biology. 162

Correlative Imaging (CI) visualizes a single sample/region of interest with two or more imaging modalities. The technique seeks to elucidate information that may not be discernible by using either of the constituent techniques in isolation. Correlati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::456478aa85fc7431b03e75883b85e9e6
https://pubmed.ncbi.nlm.nih.gov/33707021

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De Novo Designed Peptide and Protein Hairpins Self-assemble into Sheets and Nanoparticles

Autor: Lorna Hodgson, Derek N. Woolfson, Johanna M. Galloway, Caroline Morris, Christopher J. Arthur, Harriet E. V. Bray, Robert L. Harniman, Jennifer Coombs, Christopher W. Wood, Ruth Sarah Rose, Deborah K. Shoemark, James F. Ross, Judith Mantell, Paul Verkade

Publikováno v: Galloway, J M, Bray, H E V, Shoemark, D K, Hodgson, L R, Coombs, J, Mantell, J M, Rose, R S, Ross, J F, Morris, C, Harniman, R L, Wood, C W, Arthur, C, Verkade, P & Woolfson, D N 2021, ' De Novo Designed Peptide and Protein Hairpins Self-assemble into Sheets and Nanoparticles ', Small, vol. 17, no. 10, 2100472 . https://doi.org/10.1002/smll.202100472
Galloway, J M, Bray, H E V, Shoemark, D K, Hodgson, L R, Coombs, J, Mantell, J M, Rose, R S, Ross, J F, Morris, C, Harniman, R L, Wood, C W, Arthur, C, Verkade, P & Woolfson, D N 2021, ' De novo designed peptide and protein hairpins self-assemble into sheets and nanoparticles ', Small . https://doi.org/10.1002/smll.202100472

The design and assembly of peptide-based materials has advanced considerably, leading to a variety of fibrous, sheet, and nanoparticle structures. A remaining challenge is to account for and control different possible supramolecular outcomes accessib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecc31a2fa1e2c26e0397ed2bf8395d4
https://hdl.handle.net/1983/4973ccc1-9d15-44d0-b564-d8a3a7beb22c

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