Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lorn Kategaya"'
Publikováno v:
iScience, Vol 13, Iss , Pp 488-497 (2019)
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions b
Externí odkaz:
https://doaj.org/article/bb89d1e0545341388d7cc3f633d07161
Autor:
Panagiotis Stanitsas, Kara Marie Liu, Lorn Kategaya, Kelly Haston, Alicia Lee, Shahin Mohammadi, Haoyang Zheng, Francesco Paolo Casale, Navpreet Ranu, Ahmed Sandakli, Pooja Prasad, Owen Chen, Anne Baldwin, Albert Kim, Eilon Sharon, Ajamete Kaykas, Daphne Koller, Matthew Albert
Publikováno v:
Journal of Hepatology. 77:S37-S38
Autor:
Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini
Publikováno v:
Journal of medicinal chemistry. 64(16)
Breast cancer remains a leading cause of cancer death in women, representing a significant unmet medical need. Here, we disclose our discovery efforts culminating in a clinical candidate, 35 (GDC-9545 or giredestrant). 35 is an efficient and potent s
Autor:
Kelly Haston, Navpreet Ranu, Lorn Kategaya, Eric Lubeck, Michael D. Bereket, Francesco Paolo Casale, Panagiotis Stanitsas, Alicia Lee, Owen Chen, Bobby Leitmann, Srinivasan Sivanandan, Ahmed Sandakli, Pooja Prasad, Rohit Loomba, Arun Sanyal, Stephen Harrison, Zobair Younossi, Catherine Jia, Grant Budas, James Trevaskis, Robert Myers, David Breckinridge, Ajamete Kaykas, Daphne Koller, Matthew Albert
Publikováno v:
Journal of Hepatology. 77:S762
Autor:
Michael D. Bereket, Francesco Paolo Casale, Lorn Kategaya, Anna Shcherbina, Navpreet Ranu, Alicia Lee, Kelly Haston, Rohit Loomba, Arun Sanyal, Stephen Harrison, Zobair Younossi, Catherine Jia, David Lopez, Li Li, Robert Myers, David Breckinridge, Andrew Billin, Ellen Berg, Santhosh Satapati, Eilon Sharon, Theofanis Karaletsos, Daphne Koller, Matthew Albert
Publikováno v:
Journal of Hepatology. 77:S31
Publikováno v:
iScience
iScience, Vol 13, Iss, Pp 488-497 (2019)
iScience, Vol 13, Iss, Pp 488-497 (2019)
Summary Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions be
Autor:
Deepak Sampath, Savita Ubhayakar, Jun Li, Ellen Ingalla, Tom De Bruyn, Ingrid E. Wertz, Jason Oeh, Jeffrey H. Hager, Scott E. Martin, Cecile Chalouni, Marc Hafner, Jennifer M. Giltnane, Lorn Kategaya, Amy Heidersbach, Lori Friedman, Amy Young, Mamie Yu, Steven J. Hartman, Robert A. Blake, Tracy Kleinheinz, Anneleen Daemen, Zora Modrusan, Xiaojing Wang, Ciara Metcalfe, René Houtman, Jane Guan, Irene P. Chen, Michelle Nannini, Wei Zhou
Publikováno v:
Cell. 178:949-963.e18
Estrogen receptor-positive (ER+) breast cancers frequently remain dependent on ER signaling even after acquiring resistance to endocrine agents, prompting the development of optimized ER antagonists. Fulvestrant is unique among approved ER therapeuti
Publikováno v:
Cancer Research. 79:2574-2574
Werner Syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss of function mutations in WRN lead to premature aging and pre-disposition to cancer. We evaluated synthetic lethality (SL) between not only o