Výsledky vyhledávání - "Lorin M. Petros"

Sequence specificity of aminoglycoside-induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy

Autor: Michael T. Howard, Brian H. Shirts, Raymond F. Gesteland, Lorin M. Petros, John F. Atkins, Kevin M. Flanigan

Publikováno v: Annals of Neurology. 48:164-169

As a result of their ability to induce translational readthrough of stop codons, the aminoglycoside antibiotics are currently being tested for efficacy in the treatment of Duchenne muscular dystrophy patients carrying a nonsense mutation in the dystr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c69b41f6af2eee0fa2dfa3e26be68c6
https://doi.org/10.1002/1531-8249(200008)48:2<164::aid-ana5>3.0.co

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Multiple Isoforms of Heparan Sulfate d-Glucosaminyl 3-O-Sulfotransferase

Autor: Nancy A. Jenkins, Masashi Kobayashi, Nicholas W. Shworak, Lijuan Zhang, Jian Liu, Lorin M. Petros, Neal G. Copeland, Robert D. Rosenberg

Publikováno v: Journal of Biological Chemistry. 274:5170-5184

3-O-Sulfated glucosaminyl residues are rare constituents of heparan sulfate and are essential for the activity of anticoagulant heparan sulfate. Cellular production of the critical active structure is controlled by the rate-limiting enzyme, heparan s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c803cd6fbda79d90e41aea5b5f9c2b4
https://doi.org/10.1074/jbc.274.8.5170

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Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus

Autor: Rose Madeira, Lorin M Petros, Emil D Parvanov, Kenneth Paigen, Petko M. Petkov, Siemon H. S. Ng

Publikováno v: BMC Molecular Biology, Vol 10, Iss 1, p 43 (2009)
BMC Molecular Biology

Background Among the three functions of DNA, mammalian replication and transcription can be subject to epigenetic imprinting specified by the parental origin of chromosomes, and although there is suggestive indication that this is also true for meiot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359dfa25c2f9eed69d7f946591b1cb03
https://doi.org/10.1186/1471-2199-10-43

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Polyamine analogs with xylene rings induce antizyme frameshifting, reduce ODC activity, and deplete cellular polyamines

Autor: Gerard F. Graminski, Debora L. Kramer, Michael T. Howard, Mark R. Burns, Lorin M. Petros, John F. Atkins, Nicholas Kisiel, Raymond F. Gesteland, Reitha S. Weeks, Susan Robinson

Publikováno v: Journal of biochemistry. 140(5)

Numerous studies have correlated elevated polyamine levels with abnormal or rapid cell growth. One therapeutic strategy to treat diseases with increased cellular proliferation rates, most obviously cancer, has been to identify compounds which lower c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfa16635070b08b18c45942d41758a9
https://pubmed.ncbi.nlm.nih.gov/16998202

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Polyamine sensing during antizyme mRNA programmed frameshifting

Autor: Michael T. Howard, Raymond F. Gesteland, John F. Atkins, Lorin M. Petros

Publikováno v: Biochemical and biophysical research communications. 338(3)

A key regulator of cellular polyamine levels from yeasts to mammals is the protein antizyme. The antizyme gene consists of two overlapping reading frames with ORF2 in the +1 frame relative to ORF1. A programmed +1 ribosomal frameshift occurs at the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895b44cb010d52b71e33111f451283d7
https://pubmed.ncbi.nlm.nih.gov/16269132

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