Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lorin E Olson"'
Autor:
Eva M Buhl, Sonja Djudjaj, Barbara M Klinkhammer, Katja Ermert, Victor G Puelles, Maja T Lindenmeyer, Clemens D Cohen, Chaoyong He, Erawan Borkham‐Kamphorst, Ralf Weiskirchen, Bernd Denecke, Panuwat Trairatphisan, Julio Saez‐Rodriguez, Tobias B Huber, Lorin E Olson, Jürgen Floege, Peter Boor
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-20 (2020)
Abstract Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the consequences of PDGFR‐β activation, we developed a model of primary ren
Externí odkaz:
https://doaj.org/article/ac0b8d90d0994948bb0f71372a3ae50d
Autor:
Yen-Chun Ho, Xin Geng, Anna O’Donnell, Jaime Ibarrola, Amaya Fernandez-Celis, Rohan Varshney, Kumar Subramani, Zheila J Azartash-Namin, Jang Kim, Robert Silasi, Jill Wylie-Sears, Zahra Alvandi, Lijuan Chen, Boksik Cha, Hong Chen, Lijun Xia, Bin Zhou, Florea Lupu, Harold M. Burkhart, Elena Aikawa, Lorin E. Olson, Jasimuddin Ahamed, Natalia López-Andrés, Joyce Bischoff, Katherine E. Yutzey, R. Sathish Srinivasan
BackgroundCardiac valve disease (CVD) is observed in 2.5% of the general population and 10% of the elderly people. Effective pharmacological treatments are currently not available, and patients with severe CVD require surgery. PROX1 and FOXC2 are tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d000032a201a79dafca023fa1d5d56fc
https://doi.org/10.1101/2023.05.10.540284
https://doi.org/10.1101/2023.05.10.540284
Autor:
Tomoaki Iwayama, Mizuho Iwashita, Kazuya Miyashita, Hiromi Sakashita, Shuji Matsumoto, Kiwako Tomita, Phan Bhongsatiern, Tomomi Kitayama, Kentaro Ikegami, Takashi Shimbo, Katsuto Tamai, Masanori A. Murayama, Shuhei Ogawa, Yoichiro Iwakura, Satoru Yamada, Lorin E. Olson, Masahide Takedachi, Shinya Murakami
Publikováno v:
Development (Cambridge, England). 149(19)
Periodontal tissue supports teeth in the alveolar bone socket via fibrous attachment of the periodontal ligament (PDL). The PDL contains periodontal fibroblasts and stem/progenitor cells, collectively known as PDL cells (PDLCs), on top of osteoblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54a0ca8cd6895ec5ecca0aca7274577
https://pubmed.ncbi.nlm.nih.gov/36245218
https://pubmed.ncbi.nlm.nih.gov/36245218
Autor:
Ayako Murao, Sumeda Nandadasa, Lorin E. Olson, Anna O’Donnell, Ronald J. Midura, Suneel S. Apte, Yu Yamaguchi
Publikováno v:
Matrix Biology. 97:40-57
Little is known about extracellular matrix (ECM) contributions to formation of the earliest cell lineages in the embryo. Here, we show that the proteoglycan versican and glycosaminoglycan hyaluronan are associated with emerging Flk1+hematoendothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09045829e8b8af6d78e586475efaf975
https://doi.org/10.1016/j.matbio.2021.01.002
https://doi.org/10.1016/j.matbio.2021.01.002
Autor:
Lorin E. Olson, Constantin Georgescu, Bharath H. Rathnakar, Shayna C. Medley, Jonathan D. Wren
Publikováno v:
Wound Repair Regen
Signal transducer and activator of transcription 1 (Stat1) is a ubiquitously expressed latent transcription factor that is activated by many cytokines and growth factors. Global Stat1 knockout mice are prone to chemical-induced lung and liver fibrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c67cfa66989a633786b02390778dd49
https://doi.org/10.1111/wrr.12807
https://doi.org/10.1111/wrr.12807
Publikováno v:
Development
Autosomal dominant PDGFRβ gain-of-function mutations in mice and humans cause a spectrum of wasting and overgrowth disorders afflicting the skeleton and other connective tissues, but the cellular origin of these disorders remains unknown. We demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165971f86600d317d47a549bb9dcc2ce
https://europepmc.org/articles/PMC8714075/
https://europepmc.org/articles/PMC8714075/
Autor:
Longbiao Yao, Bharath H. Rathnakar, Hae Ryong Kwon, Hiromi Sakashita, Jang H. Kim, Alex Rackley, James J. Tomasek, William L. Berry, Lorin E. Olson
Publikováno v:
Cell reports. 40(7)
Fibroblasts differentiate into myofibroblasts by acquiring new contractile function. This is important for tissue repair, but it also contributes to organ fibrosis. Platelet-derived growth factor (PDGF) promotes tissue repair and fibrosis, but the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9717570f55bddd5803bad90321513b5e
https://pubmed.ncbi.nlm.nih.gov/35977484
https://pubmed.ncbi.nlm.nih.gov/35977484
Publikováno v:
Cell stem cell. 28(6)
Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al. (2021) released a collection of Dre drivers and demonstrate how two recombinases can be combined to improve the cell specificity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d264f59646d7ef752b5a4fdf50fb56f5
https://pubmed.ncbi.nlm.nih.gov/33567267
https://pubmed.ncbi.nlm.nih.gov/33567267
Autor:
Bharath H. Rathnakar, James J. Tomasek, Jang Kim, Lorin E. Olson, William L. Berry, Hiromi Sakashita, Longbiao Yao
Publikováno v:
SSRN Electronic Journal.
The appearance of myofibroblasts is hallmark of fibrosis and tissue repair. Myofibroblasts are stromal cells that transition from fibroblastic progenitors by acquiring new contractile function. Platelet-derived growth factor (PDGF) promotes fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a53fe0b4af54bf8eeeb7f6ca28724e4
https://doi.org/10.2139/ssrn.3912950
https://doi.org/10.2139/ssrn.3912950
Publikováno v:
Gastroenterology. 162:S-509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9097d82d4cc9edf09fc3c1a1122f6d05
https://doi.org/10.1016/s0016-5085(22)61207-1
https://doi.org/10.1016/s0016-5085(22)61207-1