Výsledky vyhledávání - "Lori Y. O'Connell"

TrkA Amino Acids Controlling Specificity for Nerve Growth Factor

Autor: Pantelis Tsoulfas, Lori Y. O'Connell, Leonard G. Presta, Jo Anne Hongo

Publikováno v: Journal of Biological Chemistry. 275:7870-7877

Neurotrophins are important for the development and maintenance of the vertebrate nervous system, mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family. The extracellular portion of the Trk rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a8c860fa29896c9546166ceb56bd25
https://doi.org/10.1074/jbc.275.11.7870

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Specificity Determinants in Neurotrophin-3 and Design of Nerve Growth Factor-Based trkC Agonists by Changing Central β-Strand Bundle Residues to Their Neurotrophin-3 Analogs

Autor: Leonard G. Presta, Lori Y. O'Connell, Pantelis Tsoulfas, Roman Urfer

Publikováno v: Biochemistry. 36:4775-4781

Neurotrophic factors mediate their signal by binding to specific cell surface receptors of the trk family. The binding sites of neurotrophin-3 (NT-3) and nerve growth factor (NGF) to their preferre...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b62234b4b68701f3cac838b74f8438
https://doi.org/10.1021/bi962877+

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An immunoglobulin-like domain determines the specificity of neurotrophin receptors

Autor: David L. Shelton, Roman Urfer, Leonard G. Presta, Luis F. Parada, Pantelis Tsoulfas, Lori Y. O'Connell

Publikováno v: Scopus-Elsevier

The neurotrophins influence survival and maintenance of vertebrate neurons in the embryonic, early post-natal and post-developmental stages of the nervous system. Binding of neurotrophins to receptors encoded by the gene family trk initiates signal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0dfddfe939ba49d70af9719662c634
https://doi.org/10.1002/j.1460-2075.1995.tb07279.x

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Inhibition of Allergic Reactions with Antibodies to IgE

Autor: Kimberly Zioncheck, Robert L. Shields, Ricardo Saban, Paula M. Jardieu, Brian M. Fendly, Lori Y. O'Connell, Deborah Thomas, Leonard G. Presta, Winifred R. Whether

Publikováno v: International Archives of Allergy and Immunology. 107:308-312

Numerous clinical studies show that direct interference with the IgE response leads to a decrease or elimination of allergic symptoms. The aim of these studies was to design a therapy aimed at decreasing IgE levels in order to ameliorate atopic disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45f47e8534708c743b11e70af7d72fe
https://doi.org/10.1159/000237010

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The binding site on human immunoglobulin E for its high affinity receptor

Autor: Lori Y. O'Connell, Cornelia M. Gorman, L. G. Presta, S J Lahr, Robert L. Shields, P Jardieu, J P Porter

Publikováno v: Journal of Biological Chemistry. 269:26368-26373

Immunoglobulin (Ig) E antibodies mediate allergic responses by binding to specific high affinity receptors, Fc epsilon RI, on mast cells and basophils. Previous studies have shown that the principal Fc epsilon RI binding site is located on the third

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b509aa97f6f5f8dc98114e7931b0d83d
https://doi.org/10.1016/s0021-9258(18)47203-1

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X-ray structure of human relaxin at 1·5Å

Autor: Anthony A. Kossiakoff, Charles Eigenbrot, Michael Randal, Ernst H. Rinderknecht, Clifford Quan, John Burnier, Lori Y. O'Connell

Publikováno v: Journal of Molecular Biology. 221:15-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c3185b519b4c39b2db0c4a1bd327c6b
https://doi.org/10.1016/0022-2836(91)80196-2

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

Autor: Robert L. Shields, Leonard G. Presta, Kyu Hong, Y. Gloria Meng, Lori Y. O'Connell, Rodney G. Keck, Stefanie Weikert, Jadine Lai

Publikováno v: The Journal of biological chemistry. 277(30)

Lec13 cells, a variant Chinese hamster ovary cell line, were used to produce human IgG1 that were deficient in fucose attached to the Asn(297)-linked carbohydrate but were otherwise similar to that found in IgG1 produced in normal Chinese hamster ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def7fb0eaca351ab37ac9b2b8f2a2fd
https://pubmed.ncbi.nlm.nih.gov/11986321

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High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors

Autor: Lori Y. O'Connell, Leonard G. Presta, Jo Anne Hongo, Roman Urfer, Pantelis Tsoulfas, Wei Zhao

Publikováno v: The Journal of biological chemistry. 273(10)

Neurotrophic factors are important for survival and maintenance of neurons during developmental and adult stages of the vertebrate nervous system. The neurotrophins mediate their signal into the cell by specific interaction with tyrosine kinase recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26e6d341a3a75c4dccc2a6a72c7e8cd
https://pubmed.ncbi.nlm.nih.gov/9488719

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Anti-lgE Monoclonal Antibodies that Inhibit Allergen-Specific Histamine Release

Autor: Kimberly Zioncheck, Leonard G. Presta, Winifred Werther, Robert L. Shields, Lori Y. O'Connell, Toni Klassen, Brian M. Fendly, Paula M. Jardieu

Publikováno v: International Archives of Allergy and Immunology. 107:412-413

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f4ac607e8edfbb4adadbc70a91b700
https://doi.org/10.1159/000237058

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