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pro vyhledávání: '"Lori Tritschler"'
Autor:
Jack Goldberg, Eric I. Sbar, Generosa Grana, W. David Rodman, Jamil Khatri, Alexandre Hageboutros, Linda Devereux, Lori Tritschler
Publikováno v:
Cancer investigation. 20(5-6)
Topotecan is a topoisomerase-I inhibitor, a drug that stabilizes a covalent complex of enzymes and causes strand cleavage of DNA. 5-Fluorouracil (5FU) is an antimetabolite that interferes with DNA synthesis. Preclinical studies using human cancer cel