Interaction of background Ca 2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca 2+ waves in sheep heart

Autor: David C. Hutchings, George W. P. Madders, Barbara C. Niort, Elizabeth F. Bode, Caitlin A. Waddell, Lori S. Woods, Katharine M. Dibb, David A. Eisner, Andrew W. Trafford

Publikováno v: Hutchings, D, Madders, G, Niort, B, Bode, E, Waddell, C, Woods, L, Dibb, K, Eisner, D & Trafford, A 2022, ' Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart ', JOURNAL OF PHYSIOLOGY-LONDON . https://doi.org/10.1113/JP282168

Key pointsHeart failure is a pro-arrhythmic state and arrhythmias are a major cause of death. At the cellular level, Ca2+ waves resulting in delayed after-depolarisations are a key trigger of arrhythmias. Ca2+ waves arise when the sarcoplasmic reticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9002a54cd6ba1eab318aba7f54cc61
https://doi.org/10.1113/jp282168

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

Autor: Michael Lawless, Jessica L. Caldwell, Emma J. Radcliffe, Charlotte E. R. Smith, George W. P. Madders, David C. Hutchings, Lori S. Woods, Stephanie J. Church, Richard D. Unwin, Graeme J. Kirkwood, Lorenz K. Becker, Charles M. Pearman, Rebecca F. Taylor, David A. Eisner, Katharine M. Dibb, Andrew. W. Trafford

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)

Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and cellular structural remodeling in the form of disorganization and loss of the transverse tubule network. Indeed, survival rates for HF are worse than many commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::39b864b136f1cfa983f35c432c563617
http://link.springer.com/article/10.1038/s41598-019-42592-1