Výsledky vyhledávání

The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design

Autor: Winfred C. Wang, Sohail Rana, Russell E. Ware, Zora R. Rogers, Thomas H. Howard, Julio C. Barredo, James F. Casella, Bruce W. Thompson, Lori R. Luck, Myron A. Waclawiw, Lori Luchtman-Jones, Renee C. Rees, R. Clark Brown, Scott T. Miller, Rathi V. Iyer, Courtney D. Thornburg, Ram Kalpatthi, Sharada A. Sarnaik

Publikováno v: Pediatric Blood & Cancer. 54:250-255

Evidence of the laboratory benefits of hydroxyurea and its clinical efficacy in reducing acute vaso-occlusive events in adults and children with sickle cell anemia has accumulated for more than 15 years. A definitive clinical trial showing that hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7419c7d2f74deefc8e033bcd49b1af6
https://doi.org/10.1002/pbc.22269

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Terminal Ileal Atresia, Total Colonic Aganglionosis, and Thrombophilia

Autor: Shondell M. Bouie, Marie Peddinghaus, Marshall Z. Schwartz, Eric N. Faerber, Jean-Pierre de Chadarévian, Rajeev Prasad, Lori R. Luck

Publikováno v: Pediatric and Developmental Pathology. 12:394-397

Inherited thrombophilia, a predisposition for a hypercoagulable state, has been associated with cases of intestinal atresia. In this communication, we report a case of terminal ileal atresia and total colonic aganglionosis (Hirschsprung's disease), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e39041c9bfad8dc0a5c02e72aeff18
https://doi.org/10.2350/08-09-0534.1

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Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival

Autor: Natalya Perelman, Sandeep Batra, Hiroyuki Shimada, Lori R Luck, Punam Malik

Publikováno v: Laboratory Investigation. 83:1477-1487

Erythropoietin was traditionally considered an erythroid-restricted cytokine, but recent evidence indicates a broader role for it in nonhematopoietic tissues, specifically in neural development. Pediatric solid tumors are mostly developmental in orig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9bc3b3e9adf206b1a87a5c590a69d4
https://doi.org/10.1097/01.lab.0000090156.94795.48

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Human CD34(+) and CD34(+)CD38(-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells

Autor: Licheng Zeng, Kenneth I. Weinberg, Alan L. Hiti, Lori R Luck, Punam Malik

Publikováno v: Experimental hematology. 32(5)

Sickle cell disease (SCD) is remarkable for stress erythropoiesis. We investigated the progenitor populations contributing to erythroid stress.We characterized hematopoietic progenitor cells in sickle bone marrow and sickle peripheral blood from pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2986c2085b7a2617c10df11518829fbc
https://pubmed.ncbi.nlm.nih.gov/15145217

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