Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lori McFail-Isom"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71420 (2013)
The fine conformational subtleties of DNA structure modulate many fundamental cellular processes including gene activation/repression, cellular division, and DNA repair. Most of these cellular processes rely on the conformational heterogeneity of spe
Externí odkaz:
https://doaj.org/article/9d52cc1037d5462a9d85ec86d451245e
Publikováno v:
Journal of the American Chemical Society. 122:11048-11056
We demonstrate that DNA conformation is sensitive to cationic environment. We describe a high resolution (1.2 A) potassium form of CGCGAATTCGCG, determined from crystals grown in the presence of spermine and magnesium, along with potassium. The struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943dfa0d41766a576ac0eaff38f9ddf6
https://doi.org/10.1021/ja002244p
https://doi.org/10.1021/ja002244p
Publikováno v:
Journal of the American Chemical Society. 122:10513-10520
The structure and dynamics of the grooves of DNA are of immense importance for recognition of DNA by proteins and small molecules as well as for the packaging of DNA into nucleosomes and viral particles. Although there is general agreement that the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3abc78b9069f637ea7c3bb73058b7c1c
https://doi.org/10.1021/ja000707l
https://doi.org/10.1021/ja000707l
Publikováno v:
Biochemistry. 37:8341-8355
We describe a very accurate addition (called structure X here) to the B-DNA dodecamer family of X-ray structures. Our results confirm the observation of Drew and Dickerson [(1981) J. Mol. Biol. 151, 535-556] that the spine of hydration in AT tract DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c64e2446994a5a087c192628ade693
https://doi.org/10.1021/bi973073c
https://doi.org/10.1021/bi973073c
Autor:
Jaimie R. Anderson, Lori McFail-Isom, Joseph E. Coury, Lawrence A. Bottomley, Loren Dean Williams
Publikováno v:
Journal of the American Chemical Society. 119:3792-3796
An understanding of DNA−ligand interactions at the molecular level is important for the design of new drugs and probes that can recognize specific DNA sequences and structural motifs. Interestingly, determining the mode-of-binding of a DNA ligand i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7347377ca6fc055b752466cc2f679cf7
https://doi.org/10.1021/ja9623774
https://doi.org/10.1021/ja9623774
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12283-12286
Determining the mode-of-binding of a DNA ligand is not always straightforward. Here, we establish a scanning force microscopic assay for mode-of-binding that is (i) direct: lengths of individual DNA-ligand complexes are directly measured; (ii) rapid:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c1369a7159709f5ad68c7720fbaccb
https://doi.org/10.1073/pnas.93.22.12283
https://doi.org/10.1073/pnas.93.22.12283
Autor:
Lori McFail-Isom, Joseph E. Coury, Steven R. Presnell, Lawrence A. Bottomley, Loren Dean Williams
Publikováno v:
Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films. 13:1746-1751
DNA intercalators are planar molecules that insert between the base pairs of duplex DNA. Intercalation into DNA necessarily results in changes in DNA conformation, separating base pairs along the helical axis; thus, intercalators are of great importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4ce80ec850c8f1cc4f9c03b3de1ae5
https://doi.org/10.1116/1.579763
https://doi.org/10.1116/1.579763
Publikováno v:
Current opinion in structural biology. 9(3)
Recent X-ray diffraction, NMR spectroscopy and molecular mechanics results suggest that monovalent cations selectively partition into the minor groove of AT-tracts in DNA. These observations are consistent with DNA deformation by electrostatic collap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80ed056c44b5cd713bba7b34b3b8964
https://pubmed.ncbi.nlm.nih.gov/10361089
https://pubmed.ncbi.nlm.nih.gov/10361089
Publikováno v:
Biochemistry. 37(49)
Nucleic acid structure, stability, and reactivity are governed substantially by cations. We propose that magnesium and other biological inorganic ions unstack bases of DNA and RNA. This unstacking function of cations opposes their previously accepted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d0b61d2856967a88c6e2137be7ec04
https://pubmed.ncbi.nlm.nih.gov/9860822
https://pubmed.ncbi.nlm.nih.gov/9860822
Publikováno v:
Biochemistry. 37(48)
The potassium form of d(CGCGAATTCGCG) solved by X-ray diffraction to 1.75 A resolution indicates that monovalent cations penetrate the primary and secondary layers of the "spine of hydration". Both the sodium [Shui, X., McFail-Isom, L., Hu, G. G., an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fe38cb604232c8ca84543332470233
https://pubmed.ncbi.nlm.nih.gov/9836580
https://pubmed.ncbi.nlm.nih.gov/9836580