Výsledky vyhledávání - "Lori M. Evans"

Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Autor: Susan Boroski, David Gray, Lynne Denny, Wenjian Xu, Brian M. Campbell, Nancy C. Stratman, Al Probert, Amy B. Dounay, Lori M. Evans, Nancy Sue Barta

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6604-6607

Compounds that are both norepinephrine reuptake inhibitors (NRI) and 5-HT1(A) partial agonists may have the potential to treat neuropsychiatric disorders including attention deficit hyperactivity disorder (ADHD) and depression. Targeted screening of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7916137f2f69d7476e66bb4543f9d3d6
https://doi.org/10.1016/j.bmcl.2009.10.014

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TGFβ1 enhances formation of cellular Aβ/apoE deposits in vascular myocytes

Autor: Janusz Frackowiak, Harry Le Vine, Taraneh Haske, Thirasak Sukontasup, Adam A. Golabek, Lori M. Evans, Bozena Mazur-Kolecka

Publikováno v: Neurobiology of Aging. 24:355-364

Brain injury increases the risk of Alzheimer's disease (AD) through unknown mechanisms. We studied deposition of amyloid-beta protein (Abeta) in cells exposed to transforming growth factor beta1 (TGFbeta1), a cytokine that regulates cell metabolism d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3e5004cabaf4840ee0a96895e91424
https://doi.org/10.1016/s0197-4580(02)00095-7

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Traumatic Brain Injury Elevates the Alzheimer's Amyloid Peptide Abeta42 in Human CSF: A Possible Role for Nerve Cell Injury

Autor: Charlotte Raby, Alex E. Roher, P. F. Stahel, Lori M. Evans, Katharyn Spiegel, Mark R. Emmerling, T. Kossmann, Yu Min Kuo, P. D. Mehta, M. C. Morganti-Kossmann, M. D. Watson

Publikováno v: Annals of the New York Academy of Sciences. 903:118-122

The increased risk for Alzheimer's Disease (AD) associated with traumatic brain injury (TBI) suggests that environmental insults may influence the development of this age-related dementia. Recently, we have shown that the levels of the beta-amyloid p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693bff11fe0cc4b6588105565ced9261
https://doi.org/10.1111/j.1749-6632.2000.tb06357.x

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Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease

Autor: Walter Michael, Cuiman Cai, M. Desiree Watson, Lori M. Evans, Kevin K.W. Wang, Mark R. Emmerling, John L. Gilmore, Sheryl J. Hays, Lakshmi S. Narasimhan, Juan C. Jaen, Janet S. Plummer, Rathna Nath

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:815-820

A series of 2-sulfonyl-4H-3,1-benzoxazinones was prepared that inhibit C1r protease in vitro. Several compounds were found to be selective for C1r verses the related serine protease trypsin. Selected compounds demonstrated functional activity in a he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e738565a315f9d0c187febdcfe15521a
https://doi.org/10.1016/s0960-894x(99)00095-5

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Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists

Autor: Brian M. Campbell, Amy B. Dounay, Pil H. Lee, Nancy Sue Barta, Lori M. Evans, Terry Crawford, Susan A. Borosky, Wenjian Xu, David Gray, Lynne Denny, Jack A. Bikker, Edward A. Lenoir

Publikováno v: Bioorganicmedicinal chemistry letters. 19(4)

Aminopyrimidine 2 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-cyclopropylpyrimidin-2-amine) emerged from a high throughput screen as a novel 5-HT(1A) agonist. This compound showed moderate potency for 5-HT(1A) in binding and functional assays, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3870e7de874af8b9e1012a4ec29377a5
https://pubmed.ncbi.nlm.nih.gov/19147349

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June Jordan (1936–2002)

Autor: Megan Quinn, Carla Silva, Lori M. Evans, Sally Ann Brunot, Daniela Kocoska

Publikováno v: The Black Scholar. 32:26-27

(2002). June Jordan (1936–2002) The Black Scholar: Vol. 32, Black America: After 9/11, pp. 26-27.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13ece3a7a68b8b103c0cb57832d3a840
https://doi.org/10.1080/00064246.2002.11413188

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Evaluation of four irrational cosine definite integrals using residue theory

Autor: Lori M. Evans, James D. Evans

Publikováno v: Applied Mathematics and Computation. 33:149-159

This paper evaluates four irrational integrals that are not part of the general category of integrals that are usually evaluated by residue theory. Each integral was solved by finding the constant contribution to the [email protected]?Z term from a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff45193736fc7357cb742d5e0a6d9645
https://doi.org/10.1016/0096-3003(89)90048-9

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Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid

Autor: Katharyn Spiegel, Yu Min Kuo, Lori M. Evans, M. Desiree Watson, Thomas Kossmann, Philip F. Stahel, Maria Cristina Morganti-Kossmann, Pankaj D. Mehta, Mark R. Emmerling, Alex E. Roher, Charlotte Raby

Publikováno v: Publons

The beta-amyloid peptides, A beta1-42 and A beta1-40, were quantified in ventricular CSF taken daily for up to 3 weeks from six individuals with severe traumatic brain injury (TBI). There was considerable interindividual variability in the levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cb496eae986ff27fc25ab31eedc902
https://publons.com/publon/12753332/

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