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The Defect in Transcription-Coupled Repair Displayed by a Saccharomyces cerevisiae rad26 Mutant Is Dependent on Carbon Source and Is Not Associated With a Lack of Transcription

Autor: Lori Lommel, Kevin S. Sweder, Miriam E. Bucheli

Publikováno v: Scopus-Elsevier

Nucleotide excision repair (NER) is an evolutionarily conserved pathway that removes DNA damage induced by ultraviolet irradiation and various chemical agents that cause bulky adducts. Two subpathways within NER remove damage from the genome overall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c8fb27d373b2c72b5cb216540d0a36
https://doi.org/10.1093/genetics/158.3.989

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Transcription-coupled DNA repair in yeast transcription factor IIE (TFIIE) mutants

Autor: Lori Lommel, Karen I. Becker, Sean M. Gregory, Kevin S. Sweder

Publikováno v: Nucleic Acids Research. 28:835-842

We examined the role of yeast transcription initiation factor IIE (TFIIE) in eukaryotic transcription-coupled repair (TCR), the preferential removal of DNA damage from the transcribed strands of genes over non-transcribed sequences. TFIIE can recruit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14edaedf2e184e8b73779ef7e3ebde
https://doi.org/10.1093/nar/28.3.835

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Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells

Autor: Lori Lommel, Catherine Carswell-Crumpton, Philip C. Hanawalt

Publikováno v: Mutation Research/DNA Repair. 336:181-192

We examined repair of UV-induced cyclobutane pyrimidine dimers (CPD) in each strand of the expressed dihydrofolate reductase gene in human cells in different phases of the cell cycle: G1, early S, middle S, late S, and G2 M . After 4 h of incubation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee29f289eaa1c7957c107a28d9f88b3
https://doi.org/10.1016/0921-8777(94)00055-b

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Proteolysis of a nucleotide excision repair protein by the 26 S proteasome

Autor: Li Chen, Tatiana Ortolan, Lori Lommel, Kiran Madura, Kevin S. Sweder

Publikováno v: Current genetics. 42(1)

The 26 S proteasome degrades a broad spectrum of proteins and interacts with several nucleotide excision repair (NER) proteins, including the complex of Rad4 and Rad23 that binds preferentially to UV-damaged DNA. The rate of NER is increased in yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fd2cc0837fafe5d581fb1118402496
https://pubmed.ncbi.nlm.nih.gov/12420141

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Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: implications for Cockayne's syndrome

Autor: Miriam E. Bucheli, Lori Lommel, Kevin S. Sweder

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(16)

Cockayne's syndrome cells lack transcription-coupled nucleotide excision repair (TCR) and ubiquitylation of RNA polymerase II large subunit (RNA pol II LS), suggesting that ubiquitylation of RNA pol II LS may be necessary for TCR in eukaryotes. Rsp5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43d555526883470f5de42cb829a7d9b
https://pubmed.ncbi.nlm.nih.gov/10900266

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The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair

Autor: Kiran Madura, Li Chen, Lori Lommel, Kevin S. Sweder

Publikováno v: Nucleic acids research. 28(24)

Regulation of protein expression can be achieved through destruction of proteins by the 26S: proteasome. Cellular processes that are regulated by proteolysis include cell cycle progression, stress responses and differentiation. Several nucleotide exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488e94892fa0231d0262d1da2f235e28
https://pubmed.ncbi.nlm.nih.gov/11121474

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Preferential repair of ultraviolet light-induced DNA damage in the transcribed strand of the human p53 gene

Autor: Philip C. Hanawalt, James M. Ford, Lori Lommel

Publikováno v: Molecular carcinogenesis. 10(2)

Mutations in the p53 tumor suppressor gene have been found in most human tumors. Analyses of the spectrum of p53 mutations in certain tumor types have shown a bias for mutations originating from lesions presumed to be in the untranscribed strand of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1f31da708b9c30119d2691b1de930d
https://pubmed.ncbi.nlm.nih.gov/8031463

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Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene

Autor: Lori Lommel, Philip C. Hanawalt

Publikováno v: Molecular and cellular biology. 13(2)

A UV-resistant revertant (XP129) of a xeroderma pigmentosum group A cell line has been reported to be totally deficient in repair of cyclobutane pyrimidine dimers (CPDs) but proficient in repair of 6-4 photoproducts. This finding has been interpreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9042bba2df1526a7bd7af9c4cacf09aa
https://pubmed.ncbi.nlm.nih.gov/8423816

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The genetic defect in the Chinese hamster ovary cell mutant UV61 permits moderate selective repair of cyclobutane pyrimidine dimers in an expressed gene

Autor: Lori Lommel, Philip C. Hanawalt

Publikováno v: Mutation research. 255(2)

We examined removal of cyclobutane pyrimidine dimers (CPDs) from the dihydrofolate reductase (DHFR) gene in ultraviolet-irradiated Chinese hamster ovary (CHO) UV61 and UV5 cells. The sensitivity of UV61 cells to UV-irradiation is intermediate between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ede49d8d2536880342701a85498bcb6
https://pubmed.ncbi.nlm.nih.gov/1922150

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