Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lori L. O'Brien"'
Autor:
Pierre-Emmanuel Y. N’Guetta, Sarah R. McLarnon, Adrien Tassou, Matan Geron, Sepenta Shirvan, Rose Z. Hill, Grégory Scherrer, Lori L. O’Brien
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114860- (2024)
Summary: The kidneys act as finely tuned sensors to maintain physiological homeostasis. Both sympathetic and sensory nerves modulate kidney function through precise neural control. However, how the kidneys are innervated during development to support
Externí odkaz:
https://doaj.org/article/5bb348dc1aab4ec69a1ddd9f165ce2d9
Autor:
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/4f3047bac88542cc9b27e1ea55de683f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed s
Externí odkaz:
https://doaj.org/article/8d9aacd26e664a2bb74d69baf6205a26
Autor:
Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A Strausser, Koki Abe, Savannah Herbek, Lori L O'Brien, Steven D Crowley, Laura Barisoni, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Publikováno v:
eLife, Vol 10 (2021)
Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic appro
Externí odkaz:
https://doaj.org/article/00dbe0c73bae414ca6bbc0e4be36568e
Autor:
Lori L O'Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M Hasso, Young-Jin Lee, Alan Fang, Albert D Kim, Jinjin Guo, Trudy M Hong, Kevin A Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D Smith, Anton Valouev, Andrew P McMahon
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007181 (2018)
Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specifica
Externí odkaz:
https://doaj.org/article/435e97a2f642461e8fa6f0e4415c1cce
Autor:
Matthew Jared Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht, Martha L. Bulyk, Lori L. O'Brien
SUMMARYWilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e94ffa9d1ea16dfa218ab882db04cc
https://doi.org/10.1101/2022.11.02.514796
https://doi.org/10.1101/2022.11.02.514796
Autor:
Samuel E Honeycutt, Lori L. O'Brien
Publikováno v:
Biotechniques
Blood vessels perform critical functions in both health and disease. Understanding how vessels form, pattern and respond to damage is essential. However, labeling and imaging the vasculature to ascertain these properties can be difficult and time-con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e068d74e650505c47d7b178fd6f1d6
https://doi.org/10.2144/btn-2020-0152
https://doi.org/10.2144/btn-2020-0152
Publikováno v:
Current topics in developmental biology. 148
Proper innervation of peripheral organs helps to maintain physiological homeostasis and elicit responses to external stimuli. Disruptions to normal function can result in pathophysiological consequences. The establishment of connections and communica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d164cf3e89ccf665df46f2fb58fd34e
https://pubmed.ncbi.nlm.nih.gov/35461566
https://pubmed.ncbi.nlm.nih.gov/35461566
Autor:
Shintaro Ide, Kana Ide, Koki Abe, Yoshihiko Kobayashi, Hiroki Kitai, Jennifer McKey, Sarah A. Strausser, Lori L. O’Brien, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Publikováno v:
Cell reports. 41(6)
In both humans and mice, repair of acute kidney injury is worse in males than in females. Here, we provide evidence that this sexual dimorphism results from sex differences in ferroptosis, an iron-dependent, lipid-peroxidation-driven regulated cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f8cf1e235824a66388c0c3104f925d
https://pubmed.ncbi.nlm.nih.gov/36351395
https://pubmed.ncbi.nlm.nih.gov/36351395
Publikováno v:
Current Topics in Developmental Biology ISBN: 9780128171318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d15233ffcceb8be3a6202a6e0324f085
https://doi.org/10.1016/bs.ctdb.2022.02.004
https://doi.org/10.1016/bs.ctdb.2022.02.004