Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lori L. Bostrom"'
Autor:
Yevgeniya I. Orlovsky, Nicole Stowell, Anuk M. Das, David D. Christ, Kimberly A. Solomon, Dean A. Wacker, Douglas G. Batt, Lori L. Bostrom, Danielle M. Graden, Soo S. Ko, Erin McLaughlin, Carl P. Decicco, Gregory C. Houghton, Eric A. Wadman, Swamy Yeleswaram, Ilona Kariv, Percy H. Carter, Patricia K. Welch, Jeffrey G. Varnes, Robert C. Newton, Maryanne B. Covington, Paul Davies, James R. Pruitt, Shon K. Booker, Krishna Vaddi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2992-2997
DPC168, a benzylpiperidine-substituted aryl urea CCR3 antagonist evaluated in clinical trials, was a relatively potent inhibitor of the 2D6 isoform of cytochrome P-450 (CYP2D6). Replacement of the cyclohexyl central ring with saturated heterocycles p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1dd9c1a66cffc3a8a13b4d5ed114b4
https://doi.org/10.1016/j.bmcl.2007.03.065
https://doi.org/10.1016/j.bmcl.2007.03.065
Autor:
Brian Wayland, Brian M. Glass, Padmaja Polam, Wenyu Zhu, Amy Takvorian, Milton Hillman, Yanlong Li, Lucie Gonneville, Matthew L. Crawley, Brian Metcalf, Richard B. Sparks, Mary Becker-Pasha, Eddy W. Yue, Reid Huber, Laurine G. Galya, Erin McLaughlin, Dilip P. Modi, Richard Wynn, Brent Douty, Timothy Burn, Brian Reid, Michael J. Bower, Andrew P. Combs, Mei Li, Zelda Wasserman, Phillip Liu, Ronald M. Klabe, Min Wei, Karl F Blom, Paul J. Ala, James Russell Pruitt, Lori L. Bostrom, Gregory Hollis
Publikováno v:
Journal of Medicinal Chemistry. 48:6544-6548
Structure-based design led to the discovery of novel (S)-isothiazolidinone ((S)-IZD) heterocyclic phosphotyrosine (pTyr) mimetics that when incorporated into dipeptides are exceptionally potent, competitive, and reversible inhibitors of protein tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3391b69bc36449813d723f802b9d79a
https://doi.org/10.1021/jm0504555
https://doi.org/10.1021/jm0504555
Autor:
James R. Pruitt, Robert Bruckner, Debra Burdick, Haiying Chen, Joseph M. Luettgen, Pancras C. Wong, Ruth R. Wexler, Lori L. Bostrom, Donald J. P. Pinto, Robert M. Knabb, Patrick Y.S. Lam, Matthew R. Wright, Robert A. Galemmo, Spencer Drummond, Karen A. Rossi, Steven Bai, Angela Smallwood, Brian Wells, Richard S. Alexander
Publikováno v:
Journal of Medicinal Chemistry. 46:5298-5315
Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65338656be43b312c6b74c7c75b3327b
https://doi.org/10.1021/jm030212h
https://doi.org/10.1021/jm030212h
Autor:
Chu-Biao Xue, John Wityak, Thais M. Sielecki, Donald J. Pinto, Douglas G. Batt, Gary A. Cain, Michael Sworin, Arlene L. Rockwell, John J. Roderick, Shuaige Wang, Michael J. Orwat, William E. Frietze, Lori L. Bostrom, Jie Liu, C. Anne Higley, F. Wayne Rankin, A. Ewa Tobin, George Emmett, George K. Lalka, Jean Y. Sze, Susan V. Di Meo, Shaker A. Mousa, Martin J. Thoolen, Adrienne L. Racanelli, Elizabeth A. Hausner, Thomas M. Reilly, William F. DeGrado, Ruth R. Wexler, Richard E. Olson
Publikováno v:
Journal of Medicinal Chemistry. 40:2064-2084
Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic substituents at positions alpha and beta to the carboxylate moiety was evaluated. Of the compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b542866bf589da6d073fd44e05bd5
https://doi.org/10.1021/jm960799i
https://doi.org/10.1021/jm960799i
Autor:
Brian L. Wells, Richard S. Alexander, Joseph Buriak, Joseph Cacciola, S.L. Lee, David J. Carini, Patricia C. Weber, Pieter F. W. Stouten, Matthew M. Abelman, John M. Fevig, Gregory Loyde Hillyer, Robert A. Galemmo, Ruth R. Wexler, Karen A. Rossi, Lori L. Bostrom, Charles A. Kettner, Richard Hilmer, Robert M. Knabb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2913-2918
In this report the structure-activity relationships of a series of novel (N-acyl-N-alkyl)glycyl borolysine thrombin inhibitors are described. This work culminates in the discovery of (N-3-phenylpropanoyl-N-phenethyl)glycyl borolysine (12j), a potent,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69491b906e379ec101be8d95fd234caa
https://doi.org/10.1016/s0960-894x(96)00525-2
https://doi.org/10.1016/s0960-894x(96)00525-2
Autor:
Ronald L. Corbett, Susan R. Sherk, Ronald L. Magolda, Joseph J. Petraitis, Alicia M. Green, Lori L. Bostrom, Matthew M. Abelman, Rachel M. Kindt, Stephen W. Wright
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2875-2878
Isothiazolones and isoselenazolones have been found to inhibit IL-1β induced breakdown of bovine nasal cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, non-pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c29d2782a0dc76761e0bb25547579bf
https://doi.org/10.1016/s0960-894x(01)80782-4
https://doi.org/10.1016/s0960-894x(01)80782-4
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61e4995d05b1c01a4a18c402481e9042
https://doi.org/10.1002/chin.199232149
https://doi.org/10.1002/chin.199232149
Autor:
Patricia C. Weber, R. A. Jun. Galemmo, Joseph Cacciola, R. Hilmer, Ruth R. Wexler, Matthew M. Abelman, Gregory Loyde Hillyer, Petrus Fredericus Wilhelmus Stouten, John M. Fevig, S.L. Lee, Richard S. Alexander, Charles A. Kettner, Brian L. Wells, J. Jun. Buriak, Robert M. Knabb, Karen A. Rossi, Lori L. Bostrom, David J. Carini
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8acf5adfe57f4c0468eabe41b94f6a7c
https://doi.org/10.1002/chin.199723221
https://doi.org/10.1002/chin.199723221
Autor:
Matthew R. Wright, James Russell Pruitt, Donald J. P. Pinto, Pancras C. Wong, Lori L. Bostrom, Robert M. Knabb, Melissa J. Estrella, Ruth R. Wexler
Publikováno v:
ChemInform. 31
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6456f5c53dfd666f93d1f18fe155e7c
https://doi.org/10.1002/chin.200030111
https://doi.org/10.1002/chin.200030111
Publikováno v:
Tetrahedron Letters. 33:153-156
A new methodology is described for the synthesis of benzisothiazolones from benzylsulfinyl or t-buthylsulfinyl substituted carboxamides that provides a mild alternative to conventional cyclization methods that employ halogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e405345c36d26cea3759ff5b23d638
https://doi.org/10.1016/0040-4039(92)88037-6
https://doi.org/10.1016/0040-4039(92)88037-6