Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lori Fotheringham"'
Publikováno v:
The American journal of pathology. 185(12)
Macrophage-derived tumor necrosis factor (TNF)-α has been found in choroidal neovascularization (CNV) surgically removed from patients with age-related macular degeneration. However, the role of TNF-α in CNV development remains unclear. In a murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889ad3eb9deef892d31b6fa2f8e351ec
https://pubmed.ncbi.nlm.nih.gov/26476350
https://pubmed.ncbi.nlm.nih.gov/26476350
Autor:
Deborah U. Frank, Lori Fotheringham, Louis J. Muglia, Mario R. Capecchi, Martin Tristani-Firouzi, Judson A. Brewer, Anne M. Moon
Publikováno v:
Development. 129:4591-4603
Deletion of chromosome 22q11, the most common microdeletion detected in humans, is associated with a life-threatening array of birth defects. Although 90% of affected individuals share the same three megabase deletion, their phenotype is highly varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c0da8a7e86269d45b2af7c52ef69f6
https://doi.org/10.1242/dev.129.19.4591
https://doi.org/10.1242/dev.129.19.4591
Autor:
Haibo Wang, David Culp, Yanchao Jiang, Tal Kafri, Scott M. Hammond, John G. Flannery, Zhihong Yang, M. Elizabeth Hartnett, Lori Fotheringham
Publikováno v:
Jiang, Y; Wang, H; Culp, D; Yang, Z; Fotheringham, L; Flannery, J; et al.(2014). Targeting müller cell-derived VEGF164to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity. Investigative Ophthalmology and Visual Science, 55(2), 824-831. doi: 10.1167/iovs.13-13755. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/6nv0x5gp
Purpose. To determine whether knockdown of Müller cell-derived VEGFA-splice variant, VEGF164,which is upregulated in the rat retinopathy of prematurity (ROP) model, safely inhibits intravitreal neovascularization (IVNV). Methods. Short hairpin RNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae9ef2efbe20b0b78b77efb2b530267
https://pubmed.ncbi.nlm.nih.gov/24425851
https://pubmed.ncbi.nlm.nih.gov/24425851
Combined activity of the cancer metabolism inhibitor MPC-8640 and 5-fluorouracil in xenograft models
Autor:
Orvelin Roman, Lori Fotheringham, Robert O. Carlson, Brita Brown, J. Scott Patton, Thomas B. Douce, Lynn DeMie, Vijay Baichwal, Chad Bradford, Leslie Reeves
Publikováno v:
Journal of Clinical Oncology. 30:e13581-e13581
e13581 Background: Nicotinamide (Nam) phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in NAD biosynthesis from Nam. Nampt inhibition causes NAD depletion, inhibition of ATP synthesis and cell death. MPI-0487316 is a selective Nampt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f0e9fd9d2e47b49a12108ed4f4a3728
https://doi.org/10.1200/jco.2012.30.15_suppl.e13581
https://doi.org/10.1200/jco.2012.30.15_suppl.e13581
Autor:
Lynn DeMie, Gary Mather, Chad Bradford, Anna Costa, Lori Fotheringham, Valerie L. Belcher, Orvelin Roman
Publikováno v:
Cancer Research. 71:4386-4386
Background: Inhibition of Nampt in cancer cell lines decreases NAD levels and induces cell death. We evaluate the potential toxicity of MPC-9528, a Nampt inhibitor, and investigate the effects of coadministration of nicotinic acid (NA), the substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f99e432922f9b73dcf5a31327633a356
https://doi.org/10.1158/1538-7445.am2011-4386
https://doi.org/10.1158/1538-7445.am2011-4386